200
Participants
Start Date
February 6, 2023
Primary Completion Date
December 31, 2025
Study Completion Date
December 31, 2029
Prednisone,Vincristine, Pegylated-asparaginase, Bortezomib,Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, methotrexate, Dexamethasone, Doxorubicin
Standard risk Arm A: Induction I followed by Consolidation, extracompartmental Capizzi MTX, delayed intensification and 96 weeks' maintenance therapy. Twenty-one or twenty-six triple intrathecal injections for CNS negative or positive patients, respectively.
Prednisone,Vincristine, Pegylated-asparaginase, Bortezomib,Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, methotrexate, Dexamethasone, Doxorubicin
Standard risk Arm B: Induction I followed by Consolidation, extracompartmental high dose MTX, delayed intensification and 96 weeks' maintenance therapy. Twenty-one or twenty-six triple intrathecal injections for CNS negative or positive patients, respectively.
Prednisone,Vincristine, Pegylated-asparaginase, Bortezomib,Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine, methotrexate, Dexamethasone, Doxorubicin, Vindesine, Etoposide, Ifosfamide
High Risk T-LBL: Induction I followed by 2 cycles of BFM HR Blocks, delayed intensification and 96 weeks' maintenance therapy. Twenty-four or twenty-eight triple intrathecal injections for CNS negative or positive patients, respectively.
RECRUITING
Shanghai Children's Medical Center, Shanghai
NOT_YET_RECRUITING
West China Second University Hospital, Chengdu
Shanghai Children's Medical Center
OTHER
Beijing Children's Hospital
OTHER
Children's Hospital of Scow University
UNKNOWN
West China Second University Hospital
OTHER
Nanjing Children's Hospital
OTHER
Qilu Hospital of Shandong University
OTHER
Tianjin Medical University Cancer Institute and Hospital
OTHER
Tongji Hospital
OTHER
Xiangya Hospital of Central South University
OTHER
The First Affiliated Hospital of Zhengzhou University
OTHER
Cancer hospital of Shandong Province
UNKNOWN
Shenzhen Children's Hospital
OTHER_GOV
Wuhan Children's Hospital
OTHER
Zhejiang University School of Medicine Children's Hospital
UNKNOWN
Shanghai Children's Hospital
OTHER
Ruijin Hospital
OTHER
Second Affiliated Hospital of Anhui Medical University
UNKNOWN
Children's Hospital of Hebei Province
OTHER
Cancer Hospital of Henan Province
UNKNOWN
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
OTHER
Qilu Children's Hospital
UNKNOWN
Children's Cancer Group, China
NETWORK