Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct

PHASE4RecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

October 28, 2022

Primary Completion Date

September 30, 2025

Study Completion Date

December 31, 2025

Conditions
Diarrhoea;AcuteDiarrhea Travelers
Interventions
DRUG

Rifaximin 550 MG

Rifaximin 550 mg as a single dose administered orally.

DRUG

Azithromycin 500 MG

Azithromycin 500 mg as a single dose administered orally.

DRUG

Loperamide

4 mg loperamide administered orally with study antibiotic (rifaximin or azithromycin). Additional loperamide to use as needed, but not to exceed 16 mg/day for 2 days as per licensed use (one 2 mg capsule after each looses stool).

Trial Locations (4)

Unknown

RECRUITING

Camp Lemonnier Djibouti, Djibouti

RECRUITING

JTF-Bravo, Soto Cano AB, Comayagua

RECRUITING

British Army Training Site UK, Nanyuki

ACTIVE_NOT_RECRUITING

Fort Magsaysay & Camp Aguinaldo, Santa Rosa

All Listed Sponsors
collaborator

Infectious Diseases Clinical Research Program

OTHER

collaborator

Uniformed Services University of the Health Sciences

FED

lead

Henry M. Jackson Foundation for the Advancement of Military Medicine

OTHER