Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Markers in Ageing

NACompletedINTERVENTIONAL
Enrollment

75

Participants

Timeline

Start Date

December 5, 2022

Primary Completion Date

May 2, 2024

Study Completion Date

May 2, 2024

Conditions
Cognitive DeclineAging
Interventions
DIETARY_SUPPLEMENT

Colon-delivered multivitamin supplement

Colon-delivered multivitamin supplement containing the following dose of the indicated vitamin: vitamin B2 (10 mg), vitamin B3 (4.0 mg), vitamin B6 (1.4 mg), vitamin B9 (400 μg), vitamin C (200 mg) and vitamin D3 (15ug). Vitamin capsules are filled with microcrystalline cellulose and magnesium stearate up to 200 mg. Control of release in the colon is achieved by the Eudragit S 100 coating layer technology that surrounds the vitamins contained in the core capsules.

DIETARY_SUPPLEMENT

Placebo capsule

Placebo capsule containing microcrystalline cellulose and magnesium stearate up to 200 mg. Placebo capsules are coated with the Eudragit S 100 coating layer.

Trial Locations (2)

6525 EN

Radboud University, Donders Centre for Cognitive Neuroimaging, Nijmegen

6708 WE

Wageningen University and Research, Division of Human Nutrition and Health, Wageningen

All Listed Sponsors
collaborator

Wageningen University and Research

OTHER

lead

Donders Centre for Cognitive Neuroimaging

OTHER