NCT05673057 - Study of MP0533 in Patients Acute Myeloid Leukemia or Myelodysplastic Syndrome | Biotech Hunter

Enrollment

249

Participants

Timeline

Start Date

December 29, 2022

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2029

Conditions

LeukemiaMyeloidAcuteNewly Diagnosed

Interventions

DRUG

MP0533 (multispecific DARPin CD3 Engager Targeting CD33, CD123 and CD70) monotherapy, Part 1

MP0533 is administered by intravenous infusion

DRUG

MP0533 (multispecific DARPin CD3 Engager Targeting CD33, CD123 and CD70) monotherapy, Part 2-Arm A

"* MP0533 is administered by intravenous infusion~* Obinutuzumab pretreatment administered"

DRUG

MP0533 (multispecific DARPin CD3 Engager Targeting CD33, CD123 and CD70) + azacitidine + venetoclax

"* MP0533 is administered by intravenous infusion~* Azacitidine is administered by subcutaneous injection for 7 days per cycle~* Venetoclax is administered orally for 14 days per cycle~* Optional obinutuzumab pretreatment administered"

DRUG

MP0533 with Obinutuzumab pretreatment

"* MP0533 is administered by intravenous infusion at densified dosing schedule~* Obinutuzumab pretreatment administered"

DRUG

MP0533 + azacitidine + venetoclax with optional Obinutuzumab pretreatment, Arm B relapsed/refractory AML

"* MP0533 is administered by intravenous infusion~* Azacitidine is administered by subcutaneous injection for 7 days per cycle~* Venetoclax is administered orally for 14 days per cycle~* Optional obinutuzumab pretreatment administered"

DRUG

MP0533 + azacitidine + venetoclax with optional Obinutuzumab pretreatment, Arm B in treatment naïve patients

"* MP0533 is administered by intravenous infusion~* Azacitidine is administered by subcutaneous injection for 7 days per cycle~* Venetoclax is administered orally for 14 days per cycle~* Optional obinutuzumab pretreatment administered"

Trial Locations (9)

3010

RECRUITING

Inselspital, Universitaetsspital Bern, Bern

8006

RECRUITING

Universitaetsspital Zuerich, Zurich

75010

RECRUITING

AP-HP Hôpital Saint-Louis, Paris

Unknown

RECRUITING

CHU Bordeaux, Bordeaux

RECRUITING

IUCT Oncopole, Toulouse

RECRUITING

Vilnius University Hospital Santaros Klinikos, Vilnius

RECRUITING

Groningen UMC, Groningen

RECRUITING

Amsterdam UMC - Locatie VUmc, Amsterdam

RECRUITING

Erasmus MC, Rotterdam