A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

324

Participants

Timeline

Start Date

December 13, 2022

Primary Completion Date

February 28, 2026

Study Completion Date

October 31, 2027

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

sunvozertinib

orally, 300 mg, once daily until a treatment discontinuation criterion is met.

DRUG

Pemetrexed+carboplatin

Participants randomized into chemotherapy arm can receive up to 6 cycles of pemetrexed + carboplatin (pemetrexed 500 mg/m2 + carboplatin area under the plasma concentration-time curve 5 mg/ml per minute (AUC5), IV infusion, every 3 weeks) as the initial treatment. Participants whose disease has not progressed after 4 cycles of first-line platinum-based doublet chemotherapy may receive pemetrexed maintenance monotherapy until a treatment discontinuation criterion is met.

Trial Locations (160)

10016

NYU Laura & Issac Perlmutter Cancer Center, New York

10032

Columbia University Medical Center, New York

22908

University of Virginia Comprehensive Cancer Center, Charlottesville

33054

D&H Cancer Research Center, Margate

33324

Brcr Global, Plantation

33612

H. Lee Moffitt Cancer Center, Tampa

43210

The Ohio State University, Columbus

44718

Gabrail Cancer Center Research, Canton

75246

USOR - Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas

77030

MD Anderson cancer center, Houston

78596

USOR - Texas Oncology--Weslaco, Weslaco

80045

University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora

91203

OPN Healthcare, Inc., Glendale

94589

Kaiser Permanente Medical Center, Vallejo

97213

Providence Portland Medical Center, Portland

Unknown

Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires

Centro Diabaid, Buenos Aires

Centro Medico Austral, Buenos Aires

Consultorios Medicos Dr. Doreski - Fundacion Respirar, Buenos Aires

Fundacion Cenit Para El Estudio De Neurociencias, Buenos Aires

Hospital Italiano de Buenos Aires (HIBA), Buenos Aires

Instituto Alexander Fleming, Buenos Aires

Instituto Argentino de Diagnositco y Tratamiento S.A, Buenos Aires

Fundación Estudios Clínicos, Rosario

Fundación Ars Médica, San Salvador

Centro de Investigación Clínicas. Clinica Viedma S.A, Viedma

Concord Cancer Centre Medical Oncology Clinical Trials Unit Concord Repatriation General Hospital, Concord

Peter MacCallum Cancer Centre, Melbourne

Sir Charles Gairdner Hospital, Heart Research Insititute, Nedlands

Prince of Wales Hospital, Randwick

Ordensklinikum Linz GmbH Elisabethinen, Linz

Uniklinikum Salzburg, Salzburg

Antwerpen University Hospital (UZA), Edegem

University Hospital Gent- Drug Research Unit Ghent (D.R.U.G.), Ghent

Grand Hopital de Charleroi (GHdC) - Hopital Notre Dame, Charleroi

Fundacao PIO XII - Hospital do Cancer de Barretos, Barretos

Centro de Pesquisas Clinicas em, Cachoeiro de Itapemirim

Liga Norte Riograndense Contra o Câncer, Natal

Hospital São Lucas da PUCRS, Porto Alegre

Santa Casa de Misericordia- Porto Alegre - Hospital Santa Rita, Porto Alegre

Instituto D'Or de Pesquisa e Ensino - Recife, Recife

Instituto America(COI), Rio de Janeiro

Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro

Instituto Nacional de Cancer Jose Alencar Gomes da Silva, Rio de Janeiro

Instituto do Cancer do Estado de Sao Paulo - ICES, São Paulo

Regional Cancer Program London Health Sciences Centre, London

The Ottawa Hospital Cancer Center, Ottawa

Princess Margaret Cancer Center, Toronto

Beijing Cancer Hospital, Beijing

Beijing Chest Hospital, Capital Medical University, Beijing

Cancer Hospital of the Chinese Academy of Medical Sciences, Beijing

Peking Union Medical College Hospital, Beijing

Peking University Third Hospital, Beijing

Hunan Cancer Hospital, Changsha

West China Hospital of Sichuan University, Chengdu

Army Medical Center of PLA, Chongqing

Chongqing Cancer Hospital, Chongqing

Fujian Cancer Hospital, Fuzhou

Fujian Medical University Union Hospital, Fuzhou

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou

The First Affiliated Hospital of Sun Yat-sen University, Guangzhou

The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

Zhejiang Cancer Hospital, Hangzhou

Harbin Medical University Cancer Hospital, Harbin

Anhui Provincial Hospital, Hefei

The First Affiliated Hospital of Anhui Medical University, Hefei

The Affiliated Hospital of Inner Mongolia Medical University, Hohhot

Jilin Cancer Hospital, Jilin

Central Hospital Affiliated to Shandong First Medical University, Jinan

Shandong Cancer Hospital & Institution, Jinan

Yunnan Cancer Hospital, Kunming

The Second Affiliated Hospital of Nanchang University, Nanchang

Jiangsu Cancer Hospital, Nanjing

Jiangsu Provincial Hospital, Nanjing

Guangxi Medical University Cancer Hospital, Nanning

Shanghai Chest Hospital, Shanghai

Shanghai Pulmonary Hospital, Shanghai

ZhongShan Hospital Fudan University, Shanghai

The First Hospital of China Medical University, Shenyang

Cancer Hospital Chinese Academy of Medical Sciences, ShenZhen center, Shenzhen

The Fourth Hospital of Hebei Medical University, Shijiazhuang

Shanxi Provincial Cancer Hospital, Taiyuan

Taizhou Hospital of Zhejiang Province, Taizhou

Tianjin Medical University Cancer Institute & Hospital, Tianjin

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

The First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an

Yantai Yuhuangding Hospital, Yantai

Henan Cancer Hospital, Zhengzhou

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

Fakultni Nemocnice Olomouc (FNOL) - Onkologicka Klinika, Olomouc

Vitkovicka Nemocnice a.s. - Plicni oddeleni, Ostrava

Centre Hospitalier Universitaire d'Angers, Angers

Hôpital Louis Pradel, Bron

Centre Hospitalier Intercommunal de Creteil (CHIC), Créteil

Centre Hospitalier Universitaire de Lille (CHU Lille) - Hopital Albert Calmette - Clinique des Maladies Respiratoires, Hellemmes-Lille

Centre Hospitalier Universitaire Grenoble Alpes (CHU Grenoble Alpes) - Hopital Albert Michallon, La Tronche

APHM-Hôpital NORD, Marseille

Centre de Cancérologie Montpellier, Montpellier

APHP Hôpital Tenon, Paris

Cochin Hospital, Paris

Hopital Saint Joseph, Paris

Hôpital Bichat - Claude Bernard, Paris

CHU Poitiers, Poitiers

Centre Hospitalier Universitaire de Nantes (CHU de Nantes), Saint-Herblain

Institut de Cancerologie de L'Ouest, Saint-Herblain

Hopital d'Instruction Des Armees Begin, Saint-Mandé

Hopital Foch, Suresnes

Evangelische Lungenklinik Berlin - Klinik fuer Pneumologie, Berlin

Asklepios Klinik Gauting GmbH - Klinik fuer Thorakale Onkologie, Gauting

Niels-Stensen-Kliniken - Franziskus-Hospital Harderberg, Georgsmarienhütte

Universitaetsklinikum Heidelberg (UKHD) - Thoraxklinik-Heidelberg gGmbH, Heidelberg

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz - III. Medizinische Klinik und Poliklinik, Mainz

Pius-Hospital Oldenburg - Klinik fuer Haematologie und Onkologie, Oldenburg

Centro di Riferimento Oncologico (CRO Aviano), Aviano

Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi, Bologna

"Azienda Ospedaliero - Universitaria Policlinico-Vittorio Emanuele Catania", Catania

Università degli Studi di Firenze - Azienda Ospedaliero-Universitaria Careggi (AOUC) - SC di Oncologia MedicaI, Florence

Azienda USL Toscana Sud Est -Ospedale Misericordia - Grosseto, Grosseto

Servizio Sanitario Regionale Emilia-Romagna - Istituto Scientifico Romagnolo per lo Studio e La Cura dei Tumori Srl (IRST), Meldola

Azienda Ospedaliero-Universitaria di Modena (AOU Modena) - Policlinico di Modena, Modena

Azienda Ospedaliera San Gerardo - Monza, Monza

La Maddalena Casa di Cura di Alta Specialita - Palermo, Palermo

Azienda Ospedaliero-Universitaria di Parma, Parma

Azienda Unità Sanitaria Locale Romagna, Ravenna

Azienda Ospedaliera di Reggio Emilia - Arcispedale S. Maria Nuova (ASMN), Reggio Emilia

IRCCS Istituti Fisioterapici Ospitalieri- Istituto Nazionale tumori Regina Elena, Roma

Azienda Ospedaliera Universitaria Senese - Istituto Toscano Tumori (ITT) - Center for Immuno-Oncology (CIO), Siena

Universiteit Maastricht (UM) - Maastricht University Medical Centre (Maastricht UMC+), Maastricht

Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk

MED-POLONIA Sp. z o.o., Poznan

Wojewódzki Szpital im. św. Ojca Pio, Przemyśl

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy, Warsaw

Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Germans Trias i Pujol, Barcelona

Complejo Hospitalario Universitario A Coruña, A Coruña

Hospital de la Santa Creu i Sant Pau, Barcelona

Hospital Universitari Vall d'Hebron, Barcelona

Instituto Oncológico Dr Rosell Hospital Quiron Dexeus, Barcelona

UOMI Cancer Center - Clinica Tres Torres, Barcelona

Institut Catala d'Oncologia de Girona -Hospital Universitari Dr Josep Trueta, Girona

Hospital Universitario de Jerez, Jerez de la Frontera

Clínica Universidad de Navarra - Madrid, Madrid

Hospital HM Sanchinarro, Madrid

Hospital Universitario 12 de Octubre, Madrid

Hospital Universitario Fundación Jiménez Diaz, Madrid

Hospital Universitario La Paz, Madrid

Hospital Regional Universitario de Málaga, Málaga

Hospital Universitario Virgen de Valme, Seville

Hospital Universitario Virgen del Rocio, Seville

Hospital Universitario Virgen Macarena, Seville

Hospital Clinico Universitario de Valencia, Valencia

Hospital Universitari i Politècnic La Fe, Valencia

Ankara Bilkent City Hospital Universiteler Mahallesi, Ankara

Dr. Abdurrahman Yurtaslan Ankara Oncology Training, Ankara

Gazi Universitesi Tip Fakultesi (Gazi University Faculty of Medicine) - Gazi Hastanesi (Gazi Hospital), Ankara

Liv Hospital Ankara - Medical Oncology Clinic, Ankara

Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi Hastane, Edirne

Bezmialem University Hospital, Istanbul

Prof. Dr. Süleyman Yalçın Şehir Hastanesi - Tibbi Onkoloji Klinigi, Kadıköy

Necmettin Erbakan University, Konya

Sponsors
All Listed Sponsors
lead

Dizal Pharmaceuticals

INDUSTRY