324
Participants
Start Date
December 13, 2022
Primary Completion Date
February 28, 2026
Study Completion Date
October 31, 2027
sunvozertinib
orally, 300 mg, once daily until a treatment discontinuation criterion is met.
Pemetrexed+carboplatin
Participants randomized into chemotherapy arm can receive up to 6 cycles of pemetrexed + carboplatin (pemetrexed 500 mg/m2 + carboplatin area under the plasma concentration-time curve 5 mg/ml per minute (AUC5), IV infusion, every 3 weeks) as the initial treatment. Participants whose disease has not progressed after 4 cycles of first-line platinum-based doublet chemotherapy may receive pemetrexed maintenance monotherapy until a treatment discontinuation criterion is met.
NYU Laura & Issac Perlmutter Cancer Center, New York
Columbia University Medical Center, New York
University of Virginia Comprehensive Cancer Center, Charlottesville
D&H Cancer Research Center, Margate
Brcr Global, Plantation
H. Lee Moffitt Cancer Center, Tampa
The Ohio State University, Columbus
Gabrail Cancer Center Research, Canton
USOR - Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas
MD Anderson cancer center, Houston
USOR - Texas Oncology--Weslaco, Weslaco
University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora
OPN Healthcare, Inc., Glendale
Kaiser Permanente Medical Center, Vallejo
Providence Portland Medical Center, Portland
Centro de Educación Médica e Investigaciones Clínicas, CEMIC, Buenos Aires
Centro Diabaid, Buenos Aires
Centro Medico Austral, Buenos Aires
Consultorios Medicos Dr. Doreski - Fundacion Respirar, Buenos Aires
Fundacion Cenit Para El Estudio De Neurociencias, Buenos Aires
Hospital Italiano de Buenos Aires (HIBA), Buenos Aires
Instituto Alexander Fleming, Buenos Aires
Instituto Argentino de Diagnositco y Tratamiento S.A, Buenos Aires
Fundación Estudios Clínicos, Rosario
Fundación Ars Médica, San Salvador
Centro de Investigación Clínicas. Clinica Viedma S.A, Viedma
Concord Cancer Centre Medical Oncology Clinical Trials Unit Concord Repatriation General Hospital, Concord
Peter MacCallum Cancer Centre, Melbourne
Sir Charles Gairdner Hospital, Heart Research Insititute, Nedlands
Prince of Wales Hospital, Randwick
Ordensklinikum Linz GmbH Elisabethinen, Linz
Uniklinikum Salzburg, Salzburg
Antwerpen University Hospital (UZA), Edegem
University Hospital Gent- Drug Research Unit Ghent (D.R.U.G.), Ghent
Grand Hopital de Charleroi (GHdC) - Hopital Notre Dame, Charleroi
Fundacao PIO XII - Hospital do Cancer de Barretos, Barretos
Centro de Pesquisas Clinicas em, Cachoeiro de Itapemirim
Liga Norte Riograndense Contra o Câncer, Natal
Hospital São Lucas da PUCRS, Porto Alegre
Santa Casa de Misericordia- Porto Alegre - Hospital Santa Rita, Porto Alegre
Instituto D'Or de Pesquisa e Ensino - Recife, Recife
Instituto America(COI), Rio de Janeiro
Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro
Instituto Nacional de Cancer Jose Alencar Gomes da Silva, Rio de Janeiro
Instituto do Cancer do Estado de Sao Paulo - ICES, São Paulo
Regional Cancer Program London Health Sciences Centre, London
The Ottawa Hospital Cancer Center, Ottawa
Princess Margaret Cancer Center, Toronto
Beijing Cancer Hospital, Beijing
Beijing Chest Hospital, Capital Medical University, Beijing
Cancer Hospital of the Chinese Academy of Medical Sciences, Beijing
Peking Union Medical College Hospital, Beijing
Peking University Third Hospital, Beijing
Hunan Cancer Hospital, Changsha
West China Hospital of Sichuan University, Chengdu
Army Medical Center of PLA, Chongqing
Chongqing Cancer Hospital, Chongqing
Fujian Cancer Hospital, Fuzhou
Fujian Medical University Union Hospital, Fuzhou
The First Affiliated Hospital of Guangzhou Medical University, Guangzhou
The First Affiliated Hospital of Sun Yat-sen University, Guangzhou
The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
Harbin Medical University Cancer Hospital, Harbin
Anhui Provincial Hospital, Hefei
The First Affiliated Hospital of Anhui Medical University, Hefei
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot
Jilin Cancer Hospital, Jilin
Central Hospital Affiliated to Shandong First Medical University, Jinan
Shandong Cancer Hospital & Institution, Jinan
Yunnan Cancer Hospital, Kunming
The Second Affiliated Hospital of Nanchang University, Nanchang
Jiangsu Cancer Hospital, Nanjing
Jiangsu Provincial Hospital, Nanjing
Guangxi Medical University Cancer Hospital, Nanning
Shanghai Chest Hospital, Shanghai
Shanghai Pulmonary Hospital, Shanghai
ZhongShan Hospital Fudan University, Shanghai
The First Hospital of China Medical University, Shenyang
Cancer Hospital Chinese Academy of Medical Sciences, ShenZhen center, Shenzhen
The Fourth Hospital of Hebei Medical University, Shijiazhuang
Shanxi Provincial Cancer Hospital, Taiyuan
Taizhou Hospital of Zhejiang Province, Taizhou
Tianjin Medical University Cancer Institute & Hospital, Tianjin
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
The First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an
Yantai Yuhuangding Hospital, Yantai
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Fakultni Nemocnice Olomouc (FNOL) - Onkologicka Klinika, Olomouc
Vitkovicka Nemocnice a.s. - Plicni oddeleni, Ostrava
Centre Hospitalier Universitaire d'Angers, Angers
Hôpital Louis Pradel, Bron
Centre Hospitalier Intercommunal de Creteil (CHIC), Créteil
Centre Hospitalier Universitaire de Lille (CHU Lille) - Hopital Albert Calmette - Clinique des Maladies Respiratoires, Hellemmes-Lille
Centre Hospitalier Universitaire Grenoble Alpes (CHU Grenoble Alpes) - Hopital Albert Michallon, La Tronche
APHM-Hôpital NORD, Marseille
Centre de Cancérologie Montpellier, Montpellier
APHP Hôpital Tenon, Paris
Cochin Hospital, Paris
Hopital Saint Joseph, Paris
Hôpital Bichat - Claude Bernard, Paris
CHU Poitiers, Poitiers
Centre Hospitalier Universitaire de Nantes (CHU de Nantes), Saint-Herblain
Institut de Cancerologie de L'Ouest, Saint-Herblain
Hopital d'Instruction Des Armees Begin, Saint-Mandé
Hopital Foch, Suresnes
Evangelische Lungenklinik Berlin - Klinik fuer Pneumologie, Berlin
Asklepios Klinik Gauting GmbH - Klinik fuer Thorakale Onkologie, Gauting
Niels-Stensen-Kliniken - Franziskus-Hospital Harderberg, Georgsmarienhütte
Universitaetsklinikum Heidelberg (UKHD) - Thoraxklinik-Heidelberg gGmbH, Heidelberg
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz - III. Medizinische Klinik und Poliklinik, Mainz
Pius-Hospital Oldenburg - Klinik fuer Haematologie und Onkologie, Oldenburg
Centro di Riferimento Oncologico (CRO Aviano), Aviano
Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi, Bologna
"Azienda Ospedaliero - Universitaria Policlinico-Vittorio Emanuele Catania", Catania
Università degli Studi di Firenze - Azienda Ospedaliero-Universitaria Careggi (AOUC) - SC di Oncologia MedicaI, Florence
Azienda USL Toscana Sud Est -Ospedale Misericordia - Grosseto, Grosseto
Servizio Sanitario Regionale Emilia-Romagna - Istituto Scientifico Romagnolo per lo Studio e La Cura dei Tumori Srl (IRST), Meldola
Azienda Ospedaliero-Universitaria di Modena (AOU Modena) - Policlinico di Modena, Modena
Azienda Ospedaliera San Gerardo - Monza, Monza
La Maddalena Casa di Cura di Alta Specialita - Palermo, Palermo
Azienda Ospedaliero-Universitaria di Parma, Parma
Azienda Unità Sanitaria Locale Romagna, Ravenna
Azienda Ospedaliera di Reggio Emilia - Arcispedale S. Maria Nuova (ASMN), Reggio Emilia
IRCCS Istituti Fisioterapici Ospitalieri- Istituto Nazionale tumori Regina Elena, Roma
Azienda Ospedaliera Universitaria Senese - Istituto Toscano Tumori (ITT) - Center for Immuno-Oncology (CIO), Siena
Universiteit Maastricht (UM) - Maastricht University Medical Centre (Maastricht UMC+), Maastricht
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk
MED-POLONIA Sp. z o.o., Poznan
Wojewódzki Szpital im. św. Ojca Pio, Przemyśl
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy, Warsaw
Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Germans Trias i Pujol, Barcelona
Complejo Hospitalario Universitario A Coruña, A Coruña
Hospital de la Santa Creu i Sant Pau, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Instituto Oncológico Dr Rosell Hospital Quiron Dexeus, Barcelona
UOMI Cancer Center - Clinica Tres Torres, Barcelona
Institut Catala d'Oncologia de Girona -Hospital Universitari Dr Josep Trueta, Girona
Hospital Universitario de Jerez, Jerez de la Frontera
Clínica Universidad de Navarra - Madrid, Madrid
Hospital HM Sanchinarro, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario Fundación Jiménez Diaz, Madrid
Hospital Universitario La Paz, Madrid
Hospital Regional Universitario de Málaga, Málaga
Hospital Universitario Virgen de Valme, Seville
Hospital Universitario Virgen del Rocio, Seville
Hospital Universitario Virgen Macarena, Seville
Hospital Clinico Universitario de Valencia, Valencia
Hospital Universitari i Politècnic La Fe, Valencia
Ankara Bilkent City Hospital Universiteler Mahallesi, Ankara
Dr. Abdurrahman Yurtaslan Ankara Oncology Training, Ankara
Gazi Universitesi Tip Fakultesi (Gazi University Faculty of Medicine) - Gazi Hastanesi (Gazi Hospital), Ankara
Liv Hospital Ankara - Medical Oncology Clinic, Ankara
Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi Hastane, Edirne
Bezmialem University Hospital, Istanbul
Prof. Dr. Süleyman Yalçın Şehir Hastanesi - Tibbi Onkoloji Klinigi, Kadıköy
Necmettin Erbakan University, Konya
Lead Sponsor
Dizal Pharmaceuticals
INDUSTRY