Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders

NANot yet recruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

October 1, 2023

Primary Completion Date

March 1, 2026

Study Completion Date

April 1, 2026

Conditions
Postoperative Cognitive DysfunctionRepetitive Transcranial Magnetic Stimulation
Interventions
PROCEDURE

repetitive transcranial magnetic stimulation

"The rTMS mode consists of a cluster stimulus delivered every 0.2 seconds (5 Hz), with each cluster stimulus consisting of three burst stimuli with a 50 Hz body frequency. The duration of a single stimulus was approximately 40 seconds, for a total of 600 pulses. Stimulation takes place bilaterally in the dorsolateral prefrontal cortex (DLPFC).~All enrolled patient in the rTMS group will receive 1 set simulation per day with an intersession interval (ISI) of over 30 minutes on postoperative day 1 to 5 after the surgery."

PROCEDURE

Sham Stimulation

Shaman stimulation uses the same protocol (600 pulses per session, 3 sessions per set, ISI≥30 min, 3 sets) with the coil set at 90 against the skull on postoperative day 1 to 5 after the surgery.

All Listed Sponsors
lead

Anshi Wu

OTHER

NCT05668559 - Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders | Biotech Hunter | Biotech Hunter