An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

PHASE3Enrolling by invitationINTERVENTIONAL
Enrollment

1,400

Participants

Timeline

Start Date

November 30, 2022

Primary Completion Date

August 31, 2029

Study Completion Date

August 31, 2029

Conditions
Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Interventions
DRUG

Eplontersen

Eplontersen will be administered by SC injection.

Trial Locations (122)

1090

Medizinische Universität Wien, Vienna

2100

Rigshospitalet, Copenhagen

2145

Westmead Hospital, Westmead

2170

Liverpool Hospital, Liverpool

3168

Box Hill Hospital, Clayton

3600

Ziekenhuis Oost-Limburg - Campus Sint-Jan, Limbourg

4102

Princess Alexandra Hospital, Woolloongabba

6020

Medizinische Universität Innsbruck, Innsbruck

6027

Advara HeartCare, Joondalup

Advara HeartCare - Joondalup, Joondalup

6150

Advara HeartCare Murdoch, Murdoch

Advara HeartCare Murdoch, Murdoch

7000

Royal Hobart Hospital, Hobart

8000

Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan, Bruges

8036

Medizinische Universität Graz, Graz

10016

New York University Langone Cardiology Associates, New York

10021

Weill Cornell Medicine Cardiology, New York

10034

Columbia University Irving Medical Center, New York

13005

Hôpital de la Timone, Marseille

15706

Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela

17602

Lancaster General Hospital, Lancaster

19104

Penn Presbyterian Medical Center, Philadelphia

20010

MedStar Washington Hospital Center, Washington D.C.

20037

The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion, Washington D.C.

21201

University of Maryland Medical Center, Baltimore

23298

Virginia Commonwealth University, Richmond

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27599

University of North Carolina at Chapel Hill, Chapel Hill

27710

Duke University Medical Center, Durham

28222

Hospital Universitario Puerta de Hierro, Majadahonda

29425

Medical University of South Carolina, Charleston

30120

Hospital Clínico Universitario Virgen de la Arrixaca, Murcia

30214

Piedmont Atlanta Hospital, Fayetteville

30309

Piedmont Heart of Fayetteville, Atlanta

30322

Emory Heart and Vascular Center - Emory Clifton Campus, Atlanta

31059

Hôpital Rangueil, Toulouse

33331

Cleveland Clinic Florida, Weston

33604

Hôpital Haut-Lévêque, Pessac

35128

Azienda Ospedale Università di Padova, Padua

37232

Vanderbilt Heart and Vascular Institute, Nashville

43210

The Ohio State University College of Medicine, Columbus

44093

Centre Hospitalier Universitaire De Nantes - Hôpital Nord Laennec, Nantes

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

Cleveland Clinic Main Campus, Cleveland

45219

Carl and Edyth Lindner Research Center at The Christ Hospital, Cincinnati

46202

Indiana University Health University Hospital, Indianapolis

48149

Universitätsklinikum Münster, Münster

48202

Henry Ford Health System, Detroit

50134

Azienda Ospedaliero - Universitaria Careggi, Florence

50937

Uniklinik Köln, Cologne

53792

University of Wisconsin - Madison, Madison

55407

Allina Health Minneapolis Heart Institute - Abbott Northwestern's Heart Hospital, Minneapolis

55905

Mayo Clinic, Rochester

56124

Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanita Pubblica, Pisa

60126

Azienda Ospedaliero Universitaria Delle Marche, Ancona

60153

Loyola University Medical Center, Maywood

60611

Northwestern University, Chicago

63110

Barnes-Jewish Hospital, St Louis

64111

Saint Luke's Hospital of Kansas City, Kansas City

66160

University of Kansas Medical Center (KUMC), Kansas City

University of Kansas Medical Center, Kansas City

66421

Universitätsklinikum des Saarlandes, Homburg

69120

Universitaetsklinikum Heidelberg - Zentrum für Innere Medizin, Heidelberg

75390

University of Texas Southwestern Medical Center, Dallas

77030

Houston Methodist Hospital, Houston

80045

University of Colorado Hospital - Anschutz Medical Campus, Aurora

84112

University of Utah, Salt Lake City

85259

Mayo Clinic, Scottsdale

85925

Centre Hospitalier Départemental Vendée, La Roche-sur-Yon

90211

Cedars-Sinai Medical Center, Beverly Hills

92037

Altman Clinical and Translational Research Institute - Center for Clinical Research, La Jolla

94010

Hôpitaux Universitaires Henri Mondor, Créteil

94143

University Of California San Francisco Urology Practice, San Francisco

94305

Stanford University (Leland Stanford Junior University), Stanford

97078

Universitätsklinikum Würzburg, Würzburg

97239

Oregon Health and Science University, Portland

98195

University of Washington, Seattle

3109601

Rambam Health Care Campus, Haifa

7661041

Kaplan Medical Center, Rehovot

9112001

Hadassah University Hospital Ein Kerem, Jerusalem

13083881

Universidade Estadual de Campinas, São Paulo

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

02118

Boston University School of Medicine, Boston

C1199ABB

Hospital Italiano de Buenos Aires, Buenos Aires

C1428ART

Instituto Cardiovascular de Buenos Aires, Buenos Aires

90560-030

Hospital Moinhos de Vento, Porto Alegre

14040-030

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto

01323-030

A Beneficência Portuguesa de São Paulo - Unidade Mirante, São Paulo

04012-909

Instituto Dante Pazzanese de Cardiologia, São Paulo

05403-000

Instituto do Coração de São Paulo, São Paulo

14026-900

Centro Avançado de Pesquisa e Estudos para o Diagnóstico CAPED, São Paulo

T2N 4Z6

University of Calgary, Calgary

N6A 5A5

University Hospital - London Health Sciences Centre, London

H2X 0C1

Centre Hospitalier de l'Université de Montréal (CHUM), Montreal

G5L 5T1

Hôpital Regional de Rimouski, Rimouski

V5Z 1M9

Gordon and Leslie Diamond Health Care Centre, Vancouver

656 91

Fakultní Nemocnice u sv. Anny v Brně, Brno

116 36

Vseobecna Fakultni Nemocnice v Praze, Prague

140 21

Institut Klinické a Experimentální Medicíny, Prague

115 28

"General Hospital of Athens Alexandra", Athens

00189

Azienda Ospedaliera - Universitaria Sant' Andrea, Roma

830-0011

Kurume University Hospital, Kurume-Shi

810-0001

Saiseikai Fukuoka General Hospital, Fukuoka

860-8556

Kumamoto University Hospital, Kumamoto

31- 202

Krakowski Szpital Specjalistyczny im. Jana Pawła II, Krakow

4835-044

Hospital da Senhora da Oliveira, Guimarães

Unidade Local de Saúde do Alto Ave, E. P. E (Hospital da Senhora da Oliveira Guimarães), Guimarães

1169-024

Unidade Local de Saúde de São José, E. P. E - Hospital de Santa Marta, Lisbon

4099-001

Centro Hospitalar Universitário do Porto - Hospital Geral de Santo Antonio, Porto

Unidade Local de Saúde de Santo António, E. P. E - Hospital Geral de Santo Antonio, Porto

4200-319

Centro Hospitalar Universitário de São João, Porto

Unidade Local de Saúde de São João, EPE, Porto

08035

Hospital Universitari Vall d'Hebrón, Barcelona

413 45

Sahlgrenska Universitetssjukhuset, Gothenburg

931 86

Skellefteå lasarett, Skellefteå

ML4 3NJ

AES - Synexus - Scotland Clinical Research Centre, Bellshill

B15 2SQ

AES - Synexus - Midlands, Edgbaston

M15 6SE

Synexus - Manchester Clinical Research Centre, Manchester

CF15 9SS

AES - Synexus - Wales, Cardiff

NW3 2PF

Royal Free London NHS Foundation Trust, Hampstead

SE1 1YR

Richmond Pharmacology, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Ionis Pharmaceuticals, Inc.

INDUSTRY