Optimized Bismuth Quadruple Therapy vs Triple Standard Therapy for Helicobacter Pylori Eradication

PHASE4CompletedINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

October 17, 2022

Primary Completion Date

October 30, 2023

Study Completion Date

January 30, 2024

Conditions
Helicobacter Pylori Infection
Interventions
DRUG

Optimized bismuth quadruple therapy

Scheme that have high dosage of amoxicillin, metronidazole and omeprazole, with bismuth. The rationale of this scheme is that in Chile, amoxicillin resistance is low, clinical metronidazole is low in the doses used and the high doses ob Proton Pump Inhibitor enhanced the antimicrobial drugs

DRUG

Control

Standard eradication therapy using omeprazole, clarithromycin and amoxicillin

Trial Locations (2)

Unknown

Centro de especialidades médicas Marcoleta UC CHRISTUS, Santiago

Centro Médico UC-CHRISTUS San Joaquín, Santiago

All Listed Sponsors
lead

Pontificia Universidad Catolica de Chile

OTHER