Mechanisms Underlying the Efficacy of Prolonged Exposure

NARecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

January 1, 2027

Study Completion Date

January 1, 2027

Conditions
Posttraumatic Stress Disorder
Interventions
BEHAVIORAL

Prolonged Exposure Therapy for Posttraumatic Stress Disorder

Participation will occur throughout 17 weeks over 15 separate visits during which 10, 60-minute sessions of PE will take place. Session 1 of PE will focus on psychoeducation. Session 2 of PE will involve a continuation of psychoeducation and rationale for exposure as well as the collaborative construction of the in vivo exposure hierarchy. After session 2, participants will begin homework where they are instructed to confront situations on their hierarchy. Starting in session 3 of PE, participants will begin imaginal exposures to their worst trauma memory. This involves the participant recounting and visualizing the trauma memory aloud with the clinician in the room for 30-40 minutes. The session will end with 15-20 minutes of processing the imaginal exposure. Participants will continue in-session imaginal exposures until the end of treatment. Throughout the treatment, participants will listen to a recording of their imaginal exposure and engage in in vivo exposures daily.

Trial Locations (1)

02116

RECRUITING

VA Boston Healthcare System, Boston

All Listed Sponsors
collaborator

National Center for PTSD

FED

lead

VA Boston Healthcare System

FED