NCT05663008View on ClinicalTrials.gov

Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis

RecruitingOBSERVATIONAL
Enrollment

400

Participants

Timeline

Start Date

October 1, 2015

Primary Completion Date

January 30, 2027

Study Completion Date

September 30, 2027

Conditions
ALS (Amyotrophic Lateral Sclerosis)Postpoliomyelitis SyndromeSpinal Muscular Atrophy
Interventions
PROCEDURE

128 electrode electroencephalography (EEG), Bipolar surface electromyography (sEMG), High-density electromyography (HD-EMG)

128 electrode EEG and 8 bipolar EMG or HD-EMG will be noninvasively recorded from electrodes placed in a montage over the scalp and arm muscles while the participant is resting or performing tasks designed to engage specific cortical networks of interest (cognitive, behavioural, motor and sensory)

Trial Locations (1)

Dublin 2

RECRUITING

Academic Unit of Neurology, Trinity College Dublin, The University of Dublin, Dublin

All Listed Sponsors
collaborator

Motor Neurone Disease Association, UK

UNKNOWN

collaborator

Irish Research Council, IE

UNKNOWN

collaborator

Research Motor Neuron, IE

UNKNOWN

collaborator

Thierry Latran Foundation, FR

UNKNOWN

collaborator

ALS Association, USA

UNKNOWN

lead

University of Dublin, Trinity College

OTHER