The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study

CompletedOBSERVATIONAL
Enrollment

123

Participants

Timeline

Start Date

December 31, 2021

Primary Completion Date

January 1, 2023

Study Completion Date

January 1, 2023

Conditions
Bacterial KeratitisFungal KeratitisMixed Bacterial and Fungal KeratitisMicrobial Keratitis
Interventions
DRUG

Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution

In the observational study, patients treated with topical antibiotic moxifloxacin 0.5% eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Ceftazidime 5% + vancomycin 5%

In the observational study, patients treated with topical fortified antibiotics ceftazidime 5% and vancomycin 5% eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Gentamicin 1.4% + vancomycin 5%

In the observational study, patients treated with the topical fortified antibiotics gentamicin 1.4% and vancomycin 5% eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Natamycin 5% Oph Susp

In the observational study, patients treated with the topical natamycin 5% antifungal eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Voriconazole 1%

In the observational study, patients treated with voriconazole 1% antifungal eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Natamycin 5% + voriconazole 1%

In the observational study, patients treated with the topical natamycin 5% and voriconazole 1% antifungals eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Natamycin 5%+ ceftazidime 5% + vancomycin 5%

In the observational study, patients treated with the topical natamycin 5% and antifungal and the fortified antibiotic ceftazidime 5% and vancomycin 5% eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

DRUG

Voriconazole 1% + ceftazidime 5% + vancomycin 5%

In the observational study, patients treated with the topical voriconazole 1% antifungal and the fortified antibiotics ceftazidime 5% and vancomycin 5% eye drops as part of routine medical care are observed. The investigator does not assign any specific intervention to the study participants.

Trial Locations (1)

Unknown

Cornea Outpatient Clinic at Alexandria Main University Hospital, Alexandria

All Listed Sponsors
lead

Alexandria University

OTHER

NCT05655689 - The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study | Biotech Hunter | Biotech Hunter