NCT05651932 - A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma | Biotech Hunter

Enrollment

125

Participants

Timeline

Start Date

February 22, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

June 30, 2026

Conditions

Multiple MyelomaMyelomaMyeloma Multiple

Interventions

DRUG

Cohort A1 & A2: KTX-1001

KTX-1001: Orally for 28 days each cycle until progression. Dexamethasone: Orally once weekly

DRUG

Cohort B1 & B2: KTX-1001+Mezigdomide

Drug: KTX-1001: Orally for 28 days each cycle until progression Drug: Dexamethasone: Orally once weekly Drug: Mezigdomide Dexamethasone: Orally once weekly

DRUG

Cohort C1 & C2: KTX-1001 + Carfilzomib (KYPROLIS®)

Drug: KTX-1001: Orally for 28 days each cycle until progression Drug: Dexamethasone: Orally once weekly Drug: Carfilzomib (KYPROLIS®): IV, once weekly for 3 weeks in each 28-day cycle

DRUG

Cohort D: KTX-1001+ pomalidomide (Pomalyst, Imnovid)

Drug: KTX-1001: Orally for 28 days each cycle until progression Drug: Dexamethasone: Orally once a week Drug: Pomalidomide (Pomalyst, Imnovid): Orally, for 21 days in each 28-day cycle

Trial Locations (21)

10065

RECRUITING

Memorial Sloan-Kettering Cancer Center, New York

19104

RECRUITING

University of Pennsylvania, Philadelphia

27705

RECRUITING

Duke University Hospital, Durham

28204

RECRUITING

Atrium Health, Levine Cancer Institute, Charlotte

30322

RECRUITING

The Winship Cancer Institute of Emory University, Atlanta

31008

RECRUITING

Clínica Universidad de Navarra, Pamplona

32224

RECRUITING

Mayo Clinic Hospital - Florida, Jacksonville

37203

RECRUITING

Tennessee Oncology, Nashville

55905

RECRUITING

Mayo Clinic - Transplant Center - Rochester, Rochester

75235

RECRUITING

University of Texas Southwestern Harold C. Simmons Comprehensive Cancer Center, Dallas

94143

RECRUITING

UCSF Medical Center - Hematology and Blood and Marrow Transplant Clinic, San Francisco

02114

RECRUITING

Massachusetts General Hospital, Boston

07601

RECRUITING

Hackensack University Medical Center, Hackensack

M5G 2C4

RECRUITING

University Health Network (UHN) - Princess Margaret Cancer Centre (Princess Margaret Hospital), Toronto

Unknown

RECRUITING

Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu, Nantes

RECRUITING

Centre Hospitalier Universitaire de Poitiers (CHU de Poitiers), Poitiers

RECRUITING

Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse

RECRUITING

Universitaire de Lille, Villeneuve-d'Ascq

RECRUITING

Hospital ClÃ-nic de Barcelona, Barcelona

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

RECRUITING

Instituto de Investigacion Biomedica de Salamanca (IBSAL), Salamanca