A Precision Medicine Approach to Target Engagement for Emotion Regulation

NARecruitingINTERVENTIONAL
Enrollment

390

Participants

Timeline

Start Date

September 29, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Emotional RegulationDepressionAnxietyBorderline Personality DisorderObsessive-Compulsive DisorderPosttraumatic Stress DisorderEating Disorders
Interventions
BEHAVIORAL

Checking the Facts

Checking the Facts is a form of cognitive reappraisal in which participants identify negatively-valenced automatic thoughts and both generate and consider evidence that challenges the validity of those thoughts.

BEHAVIORAL

Opposite to Emotion Action

Opposite to Emotion Action teaches participants to identify their momentary emotion(s), identify the associated behavioral urge(s), and implement a behavior inconsistent with that urge (e.g., approaching a feared stimulus instead of avoiding it).

BEHAVIORAL

Mindfulness of Current Emotions

Mindfulness of Current Emotions teaches participants to nonjudgmentally observe the experience of their emotions, including physiological and cognitive responses to those emotions.

Trial Locations (1)

40508

RECRUITING

University of Kentucky, Lexington

All Listed Sponsors
collaborator

National Institute of Mental Health (NIMH)

NIH

lead

Matthew Southward

OTHER