Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study: Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA) Sub-study

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

3,882

Participants

Timeline

Start Date

December 16, 2022

Primary Completion Date

March 29, 2024

Study Completion Date

February 11, 2025

Conditions
COVID-19, SARS-CoV-2
Interventions
BIOLOGICAL

AZD5156 (Parent study Sentinel Safety Cohort)

"600 mg AZD5156 consisting of 300 mg AZD1061 at 100 mg/mL and 300 mg AZD3152 at 150 mg/mL~3 mL of AZD1061 2 mL of AZD3152 IM on Visit 1 Day 1"

BIOLOGICAL

Placebo (Parent study Sentinel Safety Cohort)

single dose of Placebo (3 mL + 2 mL) IM

BIOLOGICAL

EVUSHELD™ (Parent study Main Cohort)

"600 mg EVUSHELD™/AZD7442 consisting of 300 mg AZD1061 and 300 mg AZD8895, both at 100 mg/mL~2 IM injections (thigh) of 3 mL each IM on Visit 1 Day 1 and on Visit 5 Day 181"

BIOLOGICAL

AZD3152 (Parent study Main Cohort)

"300 mg AZD3152 at 150 mg/mL~1 IM injection (thigh) of 2 mL of AZD3152 on Visit 1 Day 1 and on Visit 5 Day 181"

BIOLOGICAL

Placebo (Parent study Main Cohort)

Single doses of 0.9% sodium chloride 2 mL IM for injection on Visit 1 Day 1 and Visit 5 Day 181

BIOLOGICAL

AZD3152 (Sub-study)

Single dose of 1200 mg IV at Visit 1 Day 1

BIOLOGICAL

AZD7442 - EVUSHELD™ (Sub-study)

Single dose 300 mg IM administered on Visit 1 Day 1

BIOLOGICAL

AZD7442 (EVUSHELD™) (Sub-study) Immunocompromised participants offered AZD3152

Single dose of AZD7442 (EVUSHELD™) 300 mg IM

Trial Locations (215)

2650

Research Site, Hvidovre

2951

Research Site, Abu Dhabi

3000

Research Site, Melbourne

3004

Research Site, Melbourne

3050

Research Site, Parkville

3570

Research Site, Alken

4000

Research Site, Liège

Research Site, Roskilde

4101

Research Site, Raymond Terrace

4556

Research Site, Sippy Downs

5505

Research Site, Seoul

6005

Research Site, West Perth

6150

Research Site, Murdoch

8200

Research Site, Aarhus

9100

Research Site, Aalborg

10400

Research Site, Bangkok

10700

Research Site, Bangkok

11000

Research Site, Muang

11385

Research Site, Ridgewood

11490

Research Site, Taipei

13620

Research Site, Gyeonggi-do

13700

Research Site, Seberang Jaya

14004

Research Site, Córdoba

14202

Research Site, Buffalo

14607

Research Site, Rochester

14642

Research Site, Rochester

15232

Research Site, Pittsburgh

16635

Research Site, Duncansville

17110

Research Site, Harrisburg

18103

Research Site, Allentown

19104

Research Site, Philadelphia

19107

Research Site, Philadelphia

20007

Research Site, Washington D.C.

20095

Research Site, Hamburg

21079

Research Site, Dijon

21287

Research Site, Baltimore

22003

Research Site, Annandale

23502

Research Site, Norfolk

23507

Research Site, Norfolk

27710

Research Site, Durham

28007

Research Site, Madrid

28031

Research Site, Madrid

28040

Research Site, Madrid

28112

Research Site, Monroe

28208

Research Site, Charlotte

28223

Research Site, Pozuelo de Alarcón

28403

Research Site, Wilmington

28557

Research Site, Morehead City

29303

Research Site, Spartanburg

29405

Research Site, North Charleston

29572

Research Site, Myrtle Beach

29603

Research Site, Marbella (Málaga)

29732

Research Site, Rock Hill

30029

Research Site, Nîmes

30342

Research Site, Atlanta

30625

Research Site, Hanover

31059

Research Site, Toulouse

31904

Research Site, Columbus

32003

Research Site, Fleming Island

32127

Research Site, Port Orange

32174

Research Site, Ormond Beach

32216

Research Site, Jacksonville

32256

Research Site, Jacksonville

32789

Research Site, Winter Park

32806

Research Site, Orlando

33014

Research Site, Miami Lakes

33024

Research Site, Hollywood

33125

Research Site, Miami

33126

Research Site, Miami

33134

Research Site, Coral Gables

33135

Research Site, Miami

33162

Research Site, North Miami Beach

33166

Research Site, Medley

Research Site, Miami Springs

33186

Research Site, Miami

33313

Research Site, Lauderdale Lakes

33462

Research Site, Lake Worth

33713

Research Site, St. Petersburg

33777

Research Site, Largo

33912

Research Site, Fort Myers

34555

Research Site, Abu Dhabi

34748

Research Site, Leesburg

35209

Research Site, Birmingham

35215

Research Site, Birmingham

36312

Research Site, Vigo

36608

Research Site, Mobile

37000

Research Site, Tours

37909

Research Site, Knoxville

40002

Research Site, Khon Kaen

40447

Research Site, Taichung

40503

Research Site, Lexington

40509

Research Site, Lexington

42055

Research Site, Saint-Etienne

42101

Research Site, Bowling Green

44093

Research Site, Nantes

44145

Research Site, Westlake

45147

Research Site, Essen

45267

Research Site, Cincinnati

46617

Research Site, South Bend

47003

Research Site, Valladolid

47500

Research Site, Sunway City

47712

Research Site, Evansville

47715

Research Site, Evansville

48081

Research Site, Saint Clair Shores

48202

Research Site, Detroit

48334

Research Site, Farmington Hills

48377

Research Site, Novi

49100

Research Site, Petah Tikva

49525

Research Site, Grand Rapids

50200

Research Site, Muang

50266

Research Site, West Des Moines

50924

Research Site, Cologne

52621

Research Site, Ramat Gan

53715

Research Site, Madison

55131

Research Site, Mainz

55446

Research Site, Minneapolis

56000

Research Site, Kuala Lumpur

59037

Research Site, Lille

59100

Research Site, Kuala Lumpur

59808

Research Site, Missoula

60031

Research Site, Gurnee

60527

Research Site, Burr Ridge

60612

Research Site, Chicago

60640

Research Site, Chicago

63110

Research Site, St Louis

63131

Research Site, St Louis

64114

Research Site, Kansas City

65109

Research Site, Jefferson City

66204

Research Site, Overland Park

67091

Research Site, Strasbourg

67214

Research Site, Wichita

68516

Research Site, Lincoln

70006

Research Site, Metairie

70119

Research Site, New Orleans

70605

Research Site, Lake Charles

72205

Research Site, Little Rock

75014

Research Site, Paris

75150

Research Site, Mesquite

75246

Research Site, Dallas

75475

Research Site, Paris

76904

Research Site, San Angelo

77054

Research Site, Houston

77065

Research Site, Houston

77070

Research Site, Houston

77081

Research Site, Houston

77089

Research Site, Houston

77339

Research Site, Kingwood

77384

Research Site, Shenandoah

78229

Research Site, San Antonio

78745

Research Site, Austin

79925

Research Site, El Paso

80014

Research Site, Aurora

80209

Research Site, Denver

80246

Research Site, Denver

80525

Research Site, Fort Collins

83712

Research Site, Boise

84041

Research Site, Layton

84115

Research Site, Salt Lake City

85206

Research Site, Mesa

85210

Research Site, Mesa

85306

Research Site, Glendale

85712

Research Site, Tucson

85925

Research Site, La Roche-sur-Yon

86000

Research Site, Poitiers

87109

Research Site, Albuquerque

89119

Research Site, Las Vegas

90027

Research Site, Los Angeles

90815

Research Site, Long Beach

91942

Research Site, La Mesa

92324

Research Site, Colton

92683

Research Site, Westminster

92780

Research Site, Tustin

93586

Research Site, Kuching

95350

Research Site, Modesto

95817

Research Site, Sacramento

98109

Research Site, Seattle

98506

Research Site, Olympia

100000

Research Site, Hanoi

117599

Research Site, Singapore

169608

Research Site, Singapore

308442

Research Site, Singapore

700000

Research Site, Hochiminh City

06519

Research Site, New Haven

02115

Research Site, Boston

02215

Research Site, Boston

01844

Research Site, Methuen

01107

Research Site, Springfield

01655

Research Site, Worcester

03801

Research Site, Portsmouth

07601

Research Site, Hackensack

02903

Research Site, Providence

H2X 0A9

Research Site, Montreal

H4A 3J1

Research Site, Montreal

DK-5700

Research Site, Svendborg

30-727

Research Site, Krakow

60-185

Research Site, Skórzewo

03080

Research Site, Seoul

08308

Research Site, Seoul

08916

Research Site, Badalona

08035

Research Site, Barcelona

08036

Research Site, Barcelona

08041

Research Site, Barcelona

06800

Research Site, Mérida

BS2 8DX

Research Site, Bristol

EH4 2XU

Research Site, Edinburgh

HA1 3UJ

Research Site, Harrow

LS9 7TF

Research Site, Leeds

L7 8XP

Research Site, Liverpool

SE1 7EH

Research Site, London

W1T 7HA

Research Site, London

M8 5RB

Research Site, Manchester

OX3 7LA

Research Site, Oxford

S10 2JF

Research Site, Sheffield

PL11 2TB

Research Site, Torpoint

TR1 3LJ

Research Site, Truro

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY