A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

June 7, 2023

Primary Completion Date

June 30, 2026

Study Completion Date

March 30, 2029

Conditions
Breast Cancer
Interventions
DRUG

Inavolisib

Participants will be administered a 9 milligram (mg) inavolisib tablet orally once a day (PO QD) on Days 1-28 of each 28-day cycle.

DRUG

Fulvestrant

Participants will be administered 500 mg of fulvestrant on Days 1 and 15 of Cycle 1 and then on Day 1 of each subsequent 28-day cycle.

DRUG

Alpelisib

Alpelisib will be administered to participants at the approved dose in combination with fulvestrant: 300 mg taken PO QD and on days 1-28 of each 28-day cycle.

Trial Locations (152)

333

Chang Gung Memorial Hosipital at Linkou, Taoyuan

404

China Medical University Hospital, Taichung

1200

Cliniques Universitaires St-Luc, Brussels

2010

Kinghorn Cancer Centre, Darlinghurst

2139

Concord Repatriation General Hospital, Concord

2196

Medical Oncology Centre of Rosebank, Johannesburg

2250

Gosford Hospital, Gosford

2450

Coffs Harbour Health Campus, Coffs Harbour

2650

UZ Antwerpen, Edegem

3000

UZ Leuven Gasthuisberg, Leuven

3550

Bendigo Cancer Centre, Bendigo

3900

Richards Bay Oncology Centre, KwaZulu Natal

5000

Clinique Ste-Elisabeth, Namur

6000

GHdC Site Les Viviers, Charleroi

6009

Sir Charles Gairdner Hospital, Perth

7646

Mountain View Oncology, Paarl

9000

UZ Gent, Ghent

10003

Hospital San Pedro De Alcantara, Cáceres

10048

National Taiwan University Hospital, Zhongzheng Dist.

10408

National Cancer Center, Goyang-si

11217

Taipei Veterans General Hospital, Taipei

20132

Ospedale San Raffaele, Milan

20357

Mammazentrum Hamburg am Krankenhaus Jerusalem, Hamburg

21280

Dicle University Faculty of Medicine, Diyarbakır

22030

Trakya University Medical Faculty, Edirne

22332

Inha University Hospital, Incheon

28007

Hospital General Universitario Gregorio Marañon, Madrid

28034

Hospital Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

29011

Hospital Regional Universitario Carlos Haya, Málaga

30303

Grady Health System, Atlanta

30318

Midtown West Medical, Atlanta

30322

Emory University Hospital, Atlanta

30342

Winship Cancer Institute at Emory Saint Joseph's Hospital, Atlanta

30625

Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie, Hanover

31100

IUCT Oncopole, Toulouse

33098

St. Vincenz-Krankenhaus GmbH Paderborn Frauen- und Kinderklinik St. Louise, Paderborn

33300

Polyclinique Bordeaux Nord, Bordeaux

33331

Cleveland Clinic Florida, Weston

34214

Medipol Mega Üniversite Hastanesi Göztepe, Istanbul

34298

ICM, Montpellier

34722

Goztepe Prof.Dr. Suleyman Yalcin City Hospital, Kadiköy

34890

Marmara Uni Faculty of Medicine, Istanbul

35042

Centre Eugene Marquis, Rennes

35100

Ege Uni Medical Faculty Hospital, Izmir

35360

Katip Celebi University Ataturk Training and Research Hospital, Izmir

37075

Universitätsmedizin Göttingen Georg-August-Universität, Göttingen

38100

Ospedale Santa Chiara, Trento

38320

Hospital Universitario de Canarias, San Cristóbal de La Laguna

40705

Veterans General Hospital - Taichung, Xitun Dist.

41009

Hospital Universitario Virgen Macarena, Seville

41061

Brustzentrum Rhein-Ruhr Servicegesellschaft mbH, Mönchengladbach

41404

Kyungpook National University Chilgok Hospital, Daegu

44670

Panamerican Clinical Research S.A de C.V., Guadalajara

44680

RENATI INNOVATION S.A.P.I. de C.V, Guadalajara

44718

Gabrail Cancer Center, Canton

45122

Universitätsklinikum Essen, Essen

47014

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola

49503

Cancer & Hematology Centers of Western Michigan, Grand Rapids

52074

Uniklinik RWTH Aachen Klinik für Gynäkologie und Geburtsmedizin, Aachen

55102

Minnesota Oncology Hematology, Saint Paul

58260

Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde, Morelia

64109

Centre Hospitalier de La Cote Basque, Bayonne

69008

Centre Leon Berard, Lyon

69120

Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg

70457

National Cheng Kung University Hospital, Tainan City

75231

Texas Oncology - Dallas Presbyterian Hospital, Dallas

79110

Praxis für Interdisziplinäre Onkologie und Hämatologie GbR, Freiburg im Breisgau

80220

Rocky Mountain Cancer Centers, Denver

81100

A.O. S. Anna e San Sebastiano, Caserta

84082

Institut Sainte Catherine, Avignon

90720

Cancer Blood and Specialty Clinic, Los Alamitos

95045

Humanitas Centro Catanese Di Oncologia, Misterbianco (CT)

95817

UC Davis Comprehensive Cancer Center, Sacramento

130021

The First Hospital of Jilin University, Changchun

150049

Harbin Medical University Tumor Hospital, Harbin

211100

Jiangsu Cancer Hospital, Nanjing

300000

Tianjin Cancer Hospital, Tianjin

310009

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

310016

Sir Run Run Shaw Hospital Zhejiang University, Hangzhou

310022

Zhejiang Cancer Hospital, Zhejiang

330006

The Second Affiliated Hospital to Nanchang University, Nanchang

430023

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

430079

Hubei Cancer Hospital, Wuhan

510060

Sun yat-sen University Cancer Center, Guangzhou

510180

Guangdong Provincial People's Hospital, Guangzhou

610041

Sichuan Provincial Cancer Hospital, Chengdu

710061

First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an

59040150

Liga Norte Riograndense Contra O Câncer, Natal

90017-4803

Los Angeles Cancer Network, Los Angeles

02114

Massachusetts General Hospital, Boston

97504-8332

Asante Rogue Regional Medical Center, Medford

C1125ABD

Fundación CENIT para la Investigación en Neurociencias, Buenos Aires

C1426AGE

Centro Oncologico Korben, Ciudad Autonoma Buenos Aires

F5300COE

Fundacion CORI para la Investigacion y Prevencion del Cancer, La Rioja

S2000KZE

Instituto de Oncología de Rosario, Rosario

S2000QGB

Sanatorio Parque S.A., Rosario

S2002KDS

Hosp Provincial D. Centenarios, Rosario

J5400DIL

CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica, San Juan

R8500ACE

Clinica Viedma S.A., Viedma

41810-011

Hospital da Bahia, Salvador

30210-090

NUPEC, Belo Horizonte

80420-090

Hospital Santa Cruz / Centro de Oncologia D'Or, Curitiba

50040-000

Hospital do Cancer de Pernambuco - HCP, Recife

Unknown

Instituto D?Or de Pesquisa e Ensino ? Hospital Esperança Recife, Recife

90050-170

Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

15090-000

Hospital de Base de Sao Jose do Rio Preto, São José do Rio Preto

01308-050

Hospital Sírio-Libanês, São Paulo

T2N 5G2

Arthur J.E. Child Comprehensive Cancer Center-Calgary, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

V5Z 4E6

BC Cancer ? Vancouver, Vancouver

E1C 6Z8

The Moncton Hospital, Moncton

L8V 5C2

Juravinski Hospital, Hamilton

K1Y 4E9

The Ottawa Hospital - General Campus, Ottawa

H1T 2M4

CIUSSS de l Est de l Ile de Montreal - Hopital Maisonneuve Rosemont, Montreal

H2X 0C2

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal

H3T 1E2

Jewish General Hospital, Montreal

H4J 1C5

Hôpital du Sacré-Coeur de Montreal, Montreal

01330

COI Centro Oncologico Internacional Santa Fe, Mexico City

03100

Health Pharma Professional Research, Mexico City

OncoMed, Mexico City

CENEIT Oncologicos, Mexico City

06700

ARKE Estudios Clínicos S.A. de C.V., Mexico City

85-796

Centrum Onkologii im. Prof. Franciszka ?ukaszczyka, Bydgoszcz

44-102

Narodowy Instytut Onkologii Odzia? w Gliwicach, Gliwice

62-500

Przychodnia Lekarska KOMED, Roman Karaszewski, Konin

75-581

Szpital Wojewódzki im. Miko?aja Kopernika, Koszalin

31-501

Szpital Uniwersytecki w Krakowie, Krakow

35-021

MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie, Rzeszów

02-781

Narodowy Instytut Onkologii im. M.Sklodowskiej-Curie, Warsaw

02841

Korea University Anam Hospital, Seoul

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06273

Gangnam Severance Hospital, Seoul

06351

Samsung Medical Center, Seoul

06591

Seoul St Mary's Hospital, Seoul

08908

ICO L'Hospitalet, L'Hospitalet de Llobregat

06010

Gulhane Training and Applicaton Hospital, Ankara

06520

Memorial Ankara Hastanesi, Ankara

01140

Medical Park Seyhan Hospital, Seyhan

06230

Hacettepe Uni Medical Faculty Hospital, Sihhiye/Ankara

RG24 9NA

Basingstoke and North Hampshire Hospital, Basingstoke

FY3 8NR

Blackpool Victoria Hospital, Blackpool

EH4 2XU

Western General Hospital, Edinburgh

CM20 1QX

Princess Alexandra Hospital, Harlow

EC1M 6BQ

St Bartholomew's Hospital, London

ME16 9QQ

Maidstone & Tonbridge Wells Hospital, Maidstone

HA6 2RN

Mount Vernon & Watford Trust Hospital, Northwood

OX3 7LE

Churchill Hospital, Oxford

SO22 5DG

Royal Hampshire County Hospital, Winchester

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY