TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

608

Participants

Timeline

Start Date

November 21, 2022

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2030

Conditions
Locally Advanced Rectal Cancer
Interventions
RADIATION

SCRT

5x5 Gy: 25 Gy

DRUG

CAPOX

Six cycles of CAPOX capecitabine 1000 mg/m2 orally twice daily on days 1-14, oxaliplatin 130 mg/m2 intravenously on day 1, every 3 weeks

DRUG

CAPOXIRI

Six cycles of CAPOXIRI capecitabine 800 mg/m2 orally twice daily on days 1-14, oxaliplatin 130 mg/m2 intravenously on day 1 and irinotecan 150 mg/m2 intravenously on day 1, every 3 weeks

Trial Locations (34)

Unknown

RECRUITING

National Cancer Center Hospital East, Chiba

RECRUITING

Ehime Prefectural Central Hospital, Ehime

RECRUITING

Kyushu University Hospital, Fukuoka

RECRUITING

National Hospital Organization Kyushu Cancer Center, Fukuoka

RECRUITING

National Hospital Organization Kyushu Medical Center, Fukuoka

RECRUITING

Gifu University Hospital, Gifu

RECRUITING

Hirosaki University Hospital, Hirosaki

RECRUITING

Hiroshima University Hospital, Hiroshima

RECRUITING

St. Marianna University Hospital, Kawasaki

RECRUITING

University of Occupational and Environmental Health Hospital, Kitakyushu

RECRUITING

Kochi Medical School Hospital, Kochi

RECRUITING

Kumamoto University Hospital, Kumamoto

RECRUITING

Kyoto Prefectural University of Medicine, Kyoto

RECRUITING

Nagoya University Hospital, Nagoya

RECRUITING

Ohara Memorial Kurashiki Central Medical Organization Kurashiki Central Hospital, Okayama

RECRUITING

Okayama University Hospital, Okayama

RECRUITING

Kansai Medical University Hospital, Osaka

RECRUITING

Kindai University Hospital, Osaka

RECRUITING

National Hospital Organization Osaka Medical Center, Osaka

RECRUITING

Osaka International Cancer Institute, Osaka

RECRUITING

Osaka Metropolitan University Hospital, Osaka

RECRUITING

Osaka Prefectural Hospital Organization Osaka Acute and General Medical Center, Osaka

RECRUITING

Osaka University Hospital, Osaka

RECRUITING

Kitasato University Hospital, Sagamihara

RECRUITING

Sapporo Medical University Hospital, Sapporo

RECRUITING

Keio University Hospital, Tokyo

RECRUITING

National Cancer Center Hospital, Tokyo

RECRUITING

Nippon Medical School Hospital, Tokyo

RECRUITING

Tokyo Medical University Hospital, Tokyo

RECRUITING

Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Komagome Hospital, Tokyo

RECRUITING

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama

RECRUITING

Yokohama City University Hospital, Yokohama

RECRUITING

Yokohama City University Medical Center, Yokohama

RECRUITING

Federation of National Public Service Personnel Mutual Aid Associations Yokosuka Mutual Aid Hospital, Yokosuka

All Listed Sponsors
collaborator

Japan Agency for Medical Research and Development

OTHER_GOV

lead

National Cancer Center Hospital East

OTHER