A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

PHASE2RecruitingINTERVENTIONAL
Enrollment

502

Participants

Timeline

Start Date

March 7, 2024

Primary Completion Date

March 12, 2030

Study Completion Date

March 12, 2030

Conditions
Aortic Stenosis
Interventions
DRUG

Pelacarsen (TQJ230) 80mg

Pelacarsen (TQJ230) 80mg

DRUG

Matching placebo

Matching placebo

Trial Locations (124)

1011

RECRUITING

Novartis Investigative Site, Lausanne

1190

RECRUITING

Novartis Investigative Site, Vienna

1211

RECRUITING

Novartis Investigative Site, Geneva

2650

RECRUITING

Novartis Investigative Site, Hvidovre

3600

RECRUITING

Novartis Investigative Site, Genk

4000

RECRUITING

Novartis Investigative Site, Roskilde

4021

WITHDRAWN

Novartis Investigative Site, Linz

4031

RECRUITING

Novartis Investigative Site, Basel

5530

RECRUITING

Novartis Investigative Site, Yvoir

6020

RECRUITING

Novartis Investigative Site, Innsbruck

6700

RECRUITING

Novartis Investigative Site, Esbjerg

6903

RECRUITING

Novartis Investigative Site, Lugano

8091

RECRUITING

Novartis Investigative Site, Zurich

8500

RECRUITING

Novartis Investigative Site, Kortrijk

8800

RECRUITING

Novartis Investigative Site, Roeselare

RECRUITING

Novartis Investigative Site, Viborg

9300

RECRUITING

Novartis Investigative Site, Aalst

10003

RECRUITING

Novartis Investigative Site, Cáceres

10021

ACTIVE_NOT_RECRUITING

New York Presbyterian Hospital, New York

10029

RECRUITING

Icahn School of Med at Mt Sinai, New York

13353

RECRUITING

Novartis Investigative Site, Berlin

14021

RECRUITING

Novartis Investigative Site, Prague

14642

RECRUITING

Strong Memorial Hospital, Rochester

19104

RECRUITING

Perelman School of Medicine, Philadelphia

20109

RECRUITING

Carient Heart and Vascular, Manassas

20138

RECRUITING

Novartis Investigative Site, Milan

20157

RECRUITING

Novartis Investigative Site, Milan

20162

RECRUITING

Novartis Investigative Site, Milan

20246

RECRUITING

Novartis Investigative Site, Hamburg

21339

WITHDRAWN

Novartis Investigative Site, Lüneburg

22042

RECRUITING

Virginia Heart, Falls Church

22763

RECRUITING

Novartis Investigative Site, Hamburg

24127

RECRUITING

Novartis Investigative Site, Bergamo

25123

RECRUITING

Novartis Investigative Site, Brescia

26133

RECRUITING

Novartis Investigative Site, Oldenburg

27157

RECRUITING

Wake Forest University Baptist Medical Center, Winston-Salem

28034

RECRUITING

Novartis Investigative Site, Madrid

28040

WITHDRAWN

Novartis Investigative Site, Madrid

28041

RECRUITING

Novartis Investigative Site, Madrid

33014

RECRUITING

Inpatient Research Clinical LLC, Miami Lakes

33170

RECRUITING

Novartis Investigative Site, Pordenone

33434

WITHDRAWN

Excel Medical Clinical Trials LLC, Boca Raton

33604

RECRUITING

Novartis Investigative Site, Pessac

34102

ACTIVE_NOT_RECRUITING

Advanced Research for Health Improvement LLC, Naples

34209

RECRUITING

Nova Clinical Research LLC, Bradenton

35000

RECRUITING

Novartis Investigative Site, Rennes

35128

RECRUITING

Novartis Investigative Site, Padua

35801

RECRUITING

Heart Center Research Llc, Huntsville

37007

RECRUITING

Novartis Investigative Site, Salamanca

40138

RECRUITING

Novartis Investigative Site, Bologna

43210

RECRUITING

Ohio State University, Columbus

44124

RECRUITING

Novartis Investigative Site, Cona

45147

RECRUITING

Novartis Investigative Site, Essen

45219

RECRUITING

Lindner Ctr At The Christ Hosp, Cincinnati

46010

RECRUITING

Novartis Investigative Site, Valencia

48149

RECRUITING

Novartis Investigative Site, Münster

48202

RECRUITING

Henry Ford Hospital, Detroit

RECRUITING

Henry Ford Hospital, Detroit

48504

RECRUITING

AA Medical Research Center, Flint

55407

WITHDRAWN

Minneapolis Heart Institute, Minneapolis

55455

RECRUITING

University Of Minnesota, Minneapolis

60126

RECRUITING

Novartis Investigative Site, Ancona

60594

RECRUITING

Novartis Investigative Site, Frankfurt am Main

66211

RECRUITING

Midwest Heart and Vascular Spec, Overland Park

68165

RECRUITING

Novartis Investigative Site, Mannheim

75012

RECRUITING

Novartis Investigative Site, Paris

75013

RECRUITING

Novartis Investigative Site, Paris

75015

RECRUITING

Novartis Investigative Site, Paris

77034

RECRUITING

Orion Medical, Houston

80636

RECRUITING

Novartis Investigative Site, München

81100

RECRUITING

Novartis Investigative Site, Caserta

86021

RECRUITING

Novartis Investigative Site, Poitiers

86077

RECRUITING

Novartis Investigative Site, Pozzilli

90210

RECRUITING

Cardiovascular Res Found, Beverly Hills

90211

RECRUITING

National Heart Institute, Beverly Hills

91325

RECRUITING

Valley Clinical Trials, Northridge

91723

RECRUITING

Foothill Cardiology, Covina

94143

RECRUITING

UC San Francisco Medical Center, San Francisco

RECRUITING

UC San Francisco Medical Center, San Francisco

94304

WITHDRAWN

Stanford University Medical Center, Palo Alto

2210001

RECRUITING

Novartis Investigative Site, Nahariya

3104802

RECRUITING

Novartis Investigative Site, Haifa

3109601

RECRUITING

Novartis Investigative Site, Haifa

4710243

RECRUITING

Novartis Investigative Site, Braga

4941492

RECRUITING

Novartis Investigative Site, Petah Tikva

5265601

RECRUITING

Novartis Investigative Site, Ramat Gan

6423906

RECRUITING

Novartis Investigative Site, Tel Aviv

8457108

RECRUITING

Novartis Investigative Site, Beersheba

9112001

RECRUITING

Novartis Investigative Site, Jerusalem

92103-8415

RECRUITING

University Of California San Diego, San Diego

02111

RECRUITING

Tufts Medical Center, Boston

02114

RECRUITING

Massachusetts General Hospital, Boston

RECRUITING

Massachusetts General Hospital, Boston

02115

RECRUITING

Brigham and Womens Hosp Harvard Med School, Boston

RECRUITING

Brigham and Womens Hosp Harvard Med School, Boston

48073-4192

RECRUITING

William Beaumont Hospital, Royal Oak

07901

RECRUITING

Overlook Medical Center, Summit

A 1090

RECRUITING

Novartis Investigative Site, Vienna

N1R 6V6

RECRUITING

Novartis Investigative Site, Cambridge

M6B 3H7

RECRUITING

Novartis Investigative Site, North York

K1Y 4W7

RECRUITING

Novartis Investigative Site, Ottawa

H1T 1C8

RECRUITING

Novartis Investigative Site, Montreal

H3T 1E2

RECRUITING

Novartis Investigative Site, Montreal

H4A 3J1

RECRUITING

Novartis Investigative Site, Montreal

G1V 4G5

RECRUITING

Novartis Investigative Site, Sainte-Foy

500 02

RECRUITING

Novartis Investigative Site, Hradec Králové

551 01

RECRUITING

Novartis Investigative Site, Jaroměř

128 08

RECRUITING

Novartis Investigative Site, Prague

01099

RECRUITING

Novartis Investigative Site, Dresden

1090 HM

RECRUITING

Novartis Investigative Site, Amsterdam

1105 AZ

RECRUITING

Novartis Investigative Site, Amsterdam

3079 DZ

RECRUITING

Novartis Investigative Site, Rotterdam

2755-009

RECRUITING

Novartis Investigative Site, Alcabideche

3000-075

RECRUITING

Novartis Investigative Site, Coimbra

4434 502

RECRUITING

Novartis Investigative Site, Vila Nova de Gaia

BT63 5QQ

WITHDRAWN

Novartis Investigative Site, Portadown

ED16 4SA

RECRUITING

Novartis Investigative Site, Edinburgh

LE3 9QP

RECRUITING

Novartis Investigative Site, Leicester

L14 3PE

RECRUITING

Novartis Investigative Site, Liverpool

EC1A 7BE

RECRUITING

Novartis Investigative Site, London

SE1 7EH

RECRUITING

Novartis Investigative Site, London

BT47 1SB

RECRUITING

Novartis Investigative Site, Londonderry

TS4 3BW

RECRUITING

Novartis Investigative Site, Middlesbrough

NE29 8NH

RECRUITING

Novartis Investigative Site, Tyne and Wear

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY