Telitacicept Followed With Rituximab Therapy on APS Secondary to SLE

RecruitingOBSERVATIONAL
Enrollment

80

Participants

Timeline

Start Date

October 1, 2022

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
Antiphospholipid Syndrome
Interventions
DRUG

Telitacicept

160mg once a week for 24 weeks

DRUG

Rituximab

Patients received 200mg of rituximab intravenously at week 0 and week 2.

DRUG

Aspirin

50-100mg, po, once per day (Qd) prescribed if needed and adjusted due to patient response

DRUG

Warfarin

Warfarin should be used in patients with arterial thrombosis, and rivaroxaban should be replaced if the patient cannot reach the standard or cannot tolerate it

DRUG

Hydroxychloroquine

200mg, po, twice per day (Bid) prescribed,if tolerated by the patient, the dose should remain constant during the observation period

DRUG

Prednisone

5-30mg, po, once per day(Qd) prescribed if needed and adjusted due to patient response

Trial Locations (1)

Shandong

RECRUITING

Qilu Hospital, Jinan

All Listed Sponsors
lead

Qilu Hospital of Shandong University

OTHER