A Study of CYP-001 in Combination with Corticosteroids in Adults with High-risk AGvHD

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

March 4, 2024

Primary Completion Date

October 31, 2025

Study Completion Date

June 30, 2027

Conditions
Graft Versus Host Disease, Acute
Interventions
BIOLOGICAL

CYP-001: Cymerus induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs)

Cymerus MSCs are derived from iPSCs using the proprietary Cymerus platform technology.

BIOLOGICAL

Placebo

The placebo product is identical to CYP-001, except that it contains no active agent

DRUG

Corticosteroids

All enrolled subjects in this trial must receive corticosteroids at a minimum dose of oral prednisone 2 mg/kg/day (or methylprednisolone 1.6 mg/kg/day IV) as therapy for aGvHD for at least for 72 hours post enrollment.

Trial Locations (39)

2050

RECRUITING

Royal Prince Alfred Hospital, Sydney

2145

RECRUITING

Westmead Hospital, Westmead

4029

RECRUITING

Royal Brisbane and Women's Hospital, Herston

10065

ACTIVE_NOT_RECRUITING

Weill Cornell Medicine - New York Presbyterian Hospital, New York

17033

RECRUITING

Penn State Health, Hershey

30342

RECRUITING

BMT Group of Georgia, Atlanta

32224

RECRUITING

Mayo Clinic Hospital, Jacksonville

33026

RECRUITING

Memorial healthcare System, Pembroke Pines

34318

RECRUITING

Gayrettepe Florence Nightingale Hastanesi, Istanbul

44195

RECRUITING

Cleveland Clinic, Cleveland

48201

RECRUITING

Karmanos Cancer Institute, Detroit

60208

RECRUITING

Northwestern University, Evanston

68198

RECRUITING

University Of Nebrasaka Medical Center, Omaha

72205

RECRUITING

University of Arkansas Medical Center, Little Rock

84112

RECRUITING

University of Utah, Salt Lake City

85012

RECRUITING

Banner MD Anderson, Phoenix

85288

RECRUITING

Mayo Clinic Hospital, Phoenix

Unknown

RECRUITING

Hospital Claude Huriez, Lille

RECRUITING

Hôpital Necker Enfants Malades, Paris

RECRUITING

Hôpital Universitaire Pitié-Salpêtrière, Paris

RECRUITING

Azienda Ospedaliero Universitaria delle Marche, Ancona

RECRUITING

ASST Grande Ospedale Metropolitano Niguarda, Milan

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma

RECRUITING

Istituto Clinico Humanitas, Rozzano

RECRUITING

IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo

RECRUITING

Ospedale dell'Angelo di Mestre, Venezia

RECRUITING

Vilnius University Hospital Santaros Klinikos, Vilnius

RECRUITING

ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

RECRUITING

Hospital Universitario Ramon y Cajal, Madrid

RECRUITING

Hospital Universitato De La Princesa, Madrid

RECRUITING

Hospital Universitario Virgen de la Arrixaca, Murcia

RECRUITING

Clínica Universidad de Navarra, Pamplona

RECRUITING

Anadolu Medical Center, Eskişehir

RECRUITING

Koc University, Istanbul

RECRUITING

Memorial Bahcelievler Hospital, Istanbul

RECRUITING

Izmir Medicalpark Hospital, Izmir

RECRUITING

İnonu University, Malatya

RECRUITING

Dr Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi, Yenimahalle

Sponsors
All Listed Sponsors
lead

Cynata Therapeutics Limited

INDUSTRY