Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial

PHASE4CompletedINTERVENTIONAL
Enrollment

1,020

Participants

Timeline

Start Date

December 13, 2022

Primary Completion Date

May 27, 2025

Study Completion Date

June 27, 2025

Conditions
Opioid UseAffective Symptoms
Interventions
DRUG

Placebo

The patient is given standardized questions about their well-being and affective state before and after the administration of placebo intravenously. This is carried out on the operating table right before anesthesia

DRUG

Morphine 2.5 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of 2.5 mg morphine intravenously. This is carried out on the operating table right before anesthesia

DRUG

Morphine 5 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of morphine 5 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Morphine 10 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of morphine 10 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Oxycodone 2.5 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of oxycodone 2.5 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Oxycodone 5 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of oxycodone 5 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Oxycodone 10 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of oxycodone 10 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Fentanyl 0.025 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of fentanyl 0.025 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Fentanyl 0.05 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of fentanyl 0.05 mg intravenously . This is carried out on the operating table right before anesthesia

DRUG

Fentanyl 0.1 mg i.v.

The patient is given standardized questions about their well-being and affective state before and after the administration of fentanyl 0.1 mg intravenously . This is carried out on the operating table right before anesthesia

Trial Locations (1)

Unknown

Harald Lenz, Oslo

All Listed Sponsors
collaborator

Vestre VikenHF Kongsberg Sykehus

OTHER

lead

Oslo University Hospital

OTHER