NCT05637086View on ClinicalTrials.gov

Clinical Study Evaluating Safety of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy

PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

December 20, 2022

Primary Completion Date

December 20, 2026

Study Completion Date

November 20, 2027

Conditions
Epilepsy
Interventions
DRUG

Phenytoin

Phenytoin remains a highly effective anti-epileptic drug, especially in generalized seizure management. Unfortunately, phenytoin efficacy on epileptic seizure is apparently reduced with its chronic use

DRUG

Pentoxifylline 400 MG

Pentoxifylline (PTX) has a well validated immune modulatory and anti-inflammatory efficacy

DRUG

Celecoxib 200mg

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis

Trial Locations (1)

35516

RECRUITING

Mansoura University, Al Mansurah

All Listed Sponsors
collaborator

Tanta University

OTHER

collaborator

Principal Investigator Maha Ahmed Younis, PhD Pharmacy Practice Department- Horus University

UNKNOWN

lead

Mostafa Bahaa

OTHER