NCT05635227View on ClinicalTrials.gov

Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery

NARecruitingINTERVENTIONAL
Enrollment

1,200

Participants

Timeline

Start Date

November 10, 2022

Primary Completion Date

December 31, 2027

Study Completion Date

February 29, 2028

Conditions
Coronary Artery DiseaseAortic Valve Disease
Interventions
DRUG

Dexamethasone phosphate

See description of arms

DRUG

Isotonic sodium chloride (0.9%)

See description of arms

DRUG

Olanzapine 10 MG

Olanzapine tablet pre-hidden in capsule identical to the placebo tablet

DRUG

Placebo capsule

capsule identical to capsule containing olanzapine

PROCEDURE

Flow-targeted hemodynamic management

See description of arms

PROCEDURE

Pressure-targeted hemodynamic management

See description of arms

PROCEDURE

Low tidal-volume ventilation

See description of arms

PROCEDURE

No ventilation

See description of arms

Trial Locations (1)

2200

RECRUITING

The Heart Centre, Rigshospitalet, Copenhagen

All Listed Sponsors
lead

Rigshospitalet, Denmark

OTHER