Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

396

Participants

Timeline

Start Date

June 12, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 4, 2029

Conditions
Diffuse Large B-Cell LymphomaGrade 3b Follicular LymphomaPrimary Mediastinal (Thymic) Large B-Cell LymphomaRecurrent Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell LymphomaTransformed Follic Lymph to Diff Large B-Cell LymphomaTransformed Marg Zone Lymph to Diff Large B-Cell Lymphoma
Interventions
BIOLOGICAL

Axicabtagene Ciloleucel

Given IV

PROCEDURE

Biospecimen Collection

Undergo collection of blood and tissue samples

PROCEDURE

Computed Tomography

Undergo PET-CT or CT

DRUG

Cyclophosphamide

Given IV

DRUG

Fludarabine

Given IV

BIOLOGICAL

Lisocabtagene Maraleucel

Given IV

BIOLOGICAL

Mosunetuzumab

Given IV

OTHER

Patient Observation

Undergo observation

DRUG

Polatuzumab Vedotin

Given IV

PROCEDURE

Positron Emission Tomography

Undergo PET-CT

BIOLOGICAL

Tisagenlecleucel

Given IV

Trial Locations (76)

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

14580

RECRUITING

Wilmot Cancer Institute at Webster, Webster

14642

RECRUITING

University of Rochester, Rochester

17822

RECRUITING

Geisinger Medical Center, Danville

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19104

RECRUITING

University of Pennsylvania/Abramson Cancer Center, Philadelphia

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

23298

RECRUITING

Virginia Commonwealth University/Massey Cancer Center, Richmond

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27710

RECRUITING

Duke University Medical Center, Durham

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29316

RECRUITING

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

RECRUITING

Medical University of South Carolina, Charleston

29605

RECRUITING

Prisma Health Cancer Institute - Butternut, Greenville

RECRUITING

Prisma Health Cancer Institute - Faris, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

29640

RECRUITING

Prisma Health Cancer Institute - Easley, Easley

29650

RECRUITING

Prisma Health Cancer Institute - Greer, Greer

29672

RECRUITING

Prisma Health Cancer Institute - Seneca, Seneca

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

RECRUITING

Emory Saint Joseph's Hospital, Atlanta

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

44106

RECRUITING

Case Western Reserve University, Cleveland

48075

ACTIVE_NOT_RECRUITING

Henry Ford Health Providence Southfield Hospital, Southfield

48201

RECRUITING

Wayne State University/Karmanos Cancer Institute, Detroit

48334

RECRUITING

Weisberg Cancer Treatment Center, Farmington Hills

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

RECRUITING

West Michigan Cancer Center, Kalamazoo

49009

RECRUITING

Ascension Borgess Cancer Center, Kalamazoo

49017

RECRUITING

Bronson Battle Creek, Battle Creek

49085

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

49120

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

RECRUITING

Trinity Health Muskegon Hospital, Muskegon

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

RECRUITING

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49677

RECRUITING

Corewell Health Reed City Hospital, Reed City

49684

RECRUITING

Munson Medical Center, Traverse City

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53151

RECRUITING

Froedtert and MCW Moorland Reserve Health Center, New Berlin

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

60153

RECRUITING

Loyola University Medical Center, Maywood

60612

RECRUITING

University of Illinois, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

72703

RECRUITING

Highlands Oncology Group - Fayetteville, Fayetteville

72758

RECRUITING

Highlands Oncology Group - Rogers, Rogers

72762

RECRUITING

Highlands Oncology Group, Springdale

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

83301

RECRUITING

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94143

RECRUITING

UCSF Medical Center-Parnassus, San Francisco

97045

RECRUITING

Providence Willamette Falls Medical Center, Oregon City

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

97239

RECRUITING

Oregon Health and Science University, Portland

05401

RECRUITING

University of Vermont Medical Center, Burlington

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Genentech, Inc.

INDUSTRY

lead

SWOG Cancer Research Network

NETWORK