ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids

PHASE2RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

February 3, 2023

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2027

Conditions
GlioblastomaBrain TumorCannabisBrain Tumor, Recurrent
Interventions
DRUG

Nabiximols

Oromucosal spray

DRUG

Temozolomide

Oral capsule

DRUG

Nabiximols-matched placebo

Nabiximols-matched placebo oromucosal spray

Trial Locations (22)

LL18 5UJ

NOT_YET_RECRUITING

Glan Clwyd Hospital, Bodelwyddan

HA6 2RN

RECRUITING

Mount Vernon Hospital, The Hillingdon Hospitals NHS Foundation Trust, Northwood

AB25 2ZN

RECRUITING

Aberdeen Royal Infirmary, NHS Grampian, Aberdeen

BT9 7AB

WITHDRAWN

Belfast City Hospital, Belfast Health and Social Care Trust, Belfast

B15 2TH

RECRUITING

Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham

BS2 8ED

RECRUITING

Bristol Haematology & Oncology Centre, University Hospitals Bristol & Weston NHS Foundation Trust, Bristol

CB2 0QQ

RECRUITING

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge

CF15 7QZ

RECRUITING

Velindre Cancer Centre, Velindre University NHS Trust, Cardiff

EH4 2XU

WITHDRAWN

Western General Hospital, NHS Lothian, Edinburgh

G12 0YN

WITHDRAWN

Beatson West of Scotland Cancer Centre, NHS Greater Glasgow & Clyde, Glasgow

HU16 5JQ

RECRUITING

Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Hull

LS9 7TF

RECRUITING

St James's University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds

EC1A 7BE

RECRUITING

St Bartholomew's Hospital, Barts Health NHS Trust, London

SE1 9RT

RECRUITING

Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London

W6 8RF

RECRUITING

Charing Cross Hospital, Imperial College Healthcare NHS Trust, London

ME16 9QQ

RECRUITING

Maidstone Hospital, Maidstone and Tunbridge Wells NHS Trust, Maidstone

M20 4BX

RECRUITING

The Christie Hospital, The Christie NHS Foundation Trust, Manchester

CH63 4JY

RECRUITING

Clatterbridge Cancer Centre, The Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral

NG5 1PB

RECRUITING

City Hospital, Nottingham University Hospitals NHS Trust, Nottingham

OX3 9DU

RECRUITING

Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford

PL6 8DH

RECRUITING

Derriford Hospital, University Hospitals Plymouth NHS Trust, Plymouth

SO16 6YD

WITHDRAWN

Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Southampton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Leeds

OTHER

collaborator

The Brain Tumour Charity

OTHER

collaborator

Jazz Pharmaceuticals

INDUSTRY

lead

University of Birmingham

OTHER