NCT05627245 - Testing the Safety of the Anti-cancer Drugs Tazemetostat and Belinostat in Patients With Lymphomas That Have Resisted Treatment | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

March 1, 2023

Primary Completion Date

September 1, 2026

Study Completion Date

September 1, 2026

Conditions

Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeRecurrent Follicular LymphomaRecurrent Non-Hodgkin LymphomaRecurrent Primary Cutaneous T-Cell Non-Hodgkin LymphomaRecurrent T-Cell Non-Hodgkin LymphomaRecurrent Transformed Non-Hodgkin LymphomaRefractory B-Cell Non-Hodgkin LymphomaRefractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeRefractory Follicular LymphomaRefractory Non-Hodgkin LymphomaRefractory Primary Cutaneous T-Cell Non-Hodgkin LymphomaRefractory T-Cell Non-Hodgkin LymphomaRefractory Transformed Non-Hodgkin Lymphoma

Interventions

DRUG

Belinostat

Given IV

PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan

OTHER

Pharmacokinetic Study

Pharmacokinetic study

PROCEDURE

Positron Emission Tomography and Computed Tomography Scan

Undergo PET-CT

DRUG

Tazemetostat

Given PO

Trial Locations (11)

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Clinical Research Center, Fairway

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

06520

RECRUITING

Yale University, New Haven

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH