Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis

NACompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

December 15, 2022

Primary Completion Date

June 3, 2023

Study Completion Date

June 8, 2023

Conditions
Knee OsteoarthritisCentral Pain Syndrome
Interventions
DEVICE

Transcutaneous vagus nerve stimulation

tVNS will be performed by the application of an auricular electrode placed at the cymba concha of the left ear. The auricular electrode containing the anode will be applied with a conductive gel without prior disinfection. Once the electrode fits the cymba concha comfortably, the participant will lie down or take a position that is comfortable for them. Once in position, investigators initiate tVNS for 60 minutes with a below-discomfort-threshold intensity with 25 Hz and pulse width 250 uS. The electrical parameters will be modified accordingly to keep the below-discomfort threshold during the intervention.

Trial Locations (1)

79968

University of Texas at El Paso, El Paso

All Listed Sponsors
lead

University of Texas, El Paso

OTHER