Carotid Revascularization Versus Best Medical Treatment for Asymptomatic Carotid Stenosis

NARecruitingINTERVENTIONAL
Enrollment

1,056

Participants

Timeline

Start Date

October 14, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Carotid Artery StentingCarotid EndarterectomyBest Medical TreatmentCarotid Artery Stenosis Asymptomatic
Interventions
PROCEDURE

Carotid Revascularization

Carotid Artery Stenting/Carotid Endarterectomy

DRUG

Medical Treatment

"Aspirin 100mg/ day plus clopidogrel 75mg/ day for the first three months after enrollment or revascularization, aspirin 100mg/ day after three months, and the statin dose was adjusted according to blood lipids levels. Best medical treatment also includes risk factor control: good lifestyle, smoking cessation, weight control, regular exercise, SBP \< 140 mmHg, HDL \< 70 mg/dl (1.8mmol/L), and glycemic control. Patients with poor control of risk factors were dynamically adjusted during follow-up.~In addition, patients undergoing CAS received dual antiplatelet therapy for at least 3 to 5 days before surgery, and patients undergoing CEA also received a preoperative oral antiplatelet drug (aspirin 100mg/ day, or clopidogrel 75mg/ day) for at least 3 days after enrollment."

Trial Locations (11)

100032

RECRUITING

Peking Union Medical College Hospital, Beijing

100053

RECRUITING

Xuanwu Hospital, Capital Medical University, Beijing

100192

RECRUITING

China-Japan Friendship Hospital, Beijing

200000

RECRUITING

Shanghai Changhai Hospital, Shanghai

210008

RECRUITING

Nanjing Drum Tower Hospital, Nanjing

450000

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

450052

RECRUITING

The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou

710061

RECRUITING

First Affiliated Hospital Xi'an Jiaotong University, Xi'an

830011

RECRUITING

People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi

050000

RECRUITING

The Second Hospital of Hebei Medical University, Shijiazhuang

050057

RECRUITING

Hebei General Hospital, Shijiazhuang

All Listed Sponsors
collaborator

China-Japan Friendship Hospital

OTHER

collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Changhai Hospital

OTHER

collaborator

Peking Union Medical College Hospital

OTHER

collaborator

Hebei General Hospital

OTHER

collaborator

The Second Hospital of Hebei Medical University

OTHER

collaborator

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

OTHER

collaborator

People's Hospital of Xinjiang Uygur Autonomous Region

OTHER

collaborator

Fifth Affiliated Hospital of Zhengzhou University

UNKNOWN

lead

Xuanwu Hospital, Beijing

OTHER