A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135), Daratumumab, Lenalidomide or Elranatamab and Lenalidomide Compared With Daratumumab, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant

PHASE3RecruitingINTERVENTIONAL
Enrollment

966

Participants

Timeline

Start Date

November 10, 2022

Primary Completion Date

March 31, 2028

Study Completion Date

November 29, 2031

Conditions
Multiple Myeloma
Interventions
DRUG

Elranatamab

Part 1 Dose Level 1 is not randomized. All other cohorts are randomized.

DRUG

Daratumumab

Part 1 Dose Level 1 is not randomized. All other cohorts are randomized.

DRUG

Lenalidomide

Part 1 Dose Level 1 is not randomized. All other cohorts are randomized.

DRUG

Dexamethasone

Randomized

Trial Locations (73)

333

RECRUITING

Chang Gung Medical Foundation-Linkou Branch, Taoyuan District

407

NOT_YET_RECRUITING

Taichung Veterans General Hospital, Taichung

3002

RECRUITING

Epworth Freemasons, Melbourne

3004

RECRUITING

The Alfred Hospital, Melbourne

3065

RECRUITING

St Vincent's Hospital Melbourne, Fitzroy

4217

RECRUITING

Pindara Private Hospital, Benowa

10002

RECRUITING

National Taiwan University Hospital, Taipei

10003

RECRUITING

Hospital San Pedro de Alcántara, Cáceres

10126

NOT_YET_RECRUITING

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin

12808

RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

13620

RECRUITING

Seoul National University Bundang Hospital, Seongnam

17007

RECRUITING

Institut Català d'Oncologia (ICO) - Girona, Girona

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS, Milan

20900

RECRUITING

Fondazione IRCCS San Gerardo dei Tintori, Monza

21565

RECRUITING

Gachon University Gil Medical Center, Namdong-gu

24127

NOT_YET_RECRUITING

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo

28006

RECRUITING

Hospital La Princesa, Madrid

28027

RECRUITING

Clinica Universidad de Navarra, Madrid

28040

RECRUITING

Hospital Universitario Fundación Jiménez Díaz, Madrid

29121

RECRUITING

AUSL di Piacenza, Piacenza

31008

RECRUITING

Clinica Universidad de Navarra, Pamplona

31100

NOT_YET_RECRUITING

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse

33081

NOT_YET_RECRUITING

Cro-Irccs, Aviano

46017

RECRUITING

Hospital Universitario Doctor Peset, Valencia

48121

RECRUITING

Ospedale Santa Maria delle Croci, Ravenna

56126

NOT_YET_RECRUITING

Azienda Ospedaliero Universitaria Pisana, Pisa

58128

RECRUITING

Chonnam National University Hwasun Hospital, Hwasun-gun

65124

RECRUITING

ASL PESCARA-Presidio Ospedaliero Pescara, Pescara

RECRUITING

Azienda Sanitaria Locale di Pescara, Pescara

71013

NOT_YET_RECRUITING

IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo

72076

NOT_YET_RECRUITING

Universitaetsklinikum Tuebingen, Tübingen

86021

RECRUITING

Centre Hospitalier Universitaire de Poitiers, Poitiers

90127

RECRUITING

A.O.U. Policlinico Paolo Giaccone, Palermo

300020

RECRUITING

Institute of hematology&blood disease hospital, Tianjin

404332

RECRUITING

China Medical University Hospital, Taichung

4910021

RECRUITING

Rabin Medical Center, Petah Tikva

5265601

NOT_YET_RECRUITING

The Edmond and Lily Safra Children's Hospital The Chaim Sheba Medical Center Department of Pediatric, Ramat Gan

6423906

RECRUITING

Sourasky Medical Center, Tel Aviv

8410101

NOT_YET_RECRUITING

Soroka Medical Center, Beersheba

9112001

RECRUITING

Hadassah Medical Center, Jerusalem

B3H 2Y9

RECRUITING

QEII Health Sciences Centre, Halifax

B3S 0H6

RECRUITING

Nova Scotia Health Authority, Halifax

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre, Toronto

625 00

RECRUITING

Fakultní nemocnice Brno Bohunice, Brno

708 52

RECRUITING

Fakultni nemocnice Ostrava, Ostrava

779 00

RECRUITING

Fakultni nemocnice Olomouc, Olomouc

44093 Cedex 1

RECRUITING

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu, Nantes

09116

RECRUITING

Klinikum Chemnitz, Chemnitz

106 76

RECRUITING

Evangelismos General Hospital of Athens, Athens

115 28

RECRUITING

Alexandra General Hospital of Athens, Athens

455 00

NOT_YET_RECRUITING

University Hospital of Ioannina, Ioannina

00161

RECRUITING

AOU Policlinico Umberto I, Roma

910-1193

RECRUITING

University of Fukui Hospital, Yoshida-gun

371-8511

NOT_YET_RECRUITING

Gunma University Hospital, Maebashi

028-3695

RECRUITING

Iwate Medical University Hospital, Yahaba-cho

980-8574

RECRUITING

Tohoku University Hospital, Sendai

411-8777

RECRUITING

Shizuoka Cancer Center, Nagaizumi-cho

150-8935

NOT_YET_RECRUITING

Japanese Red Cross Medical Center, Shibuya-ku

812-8582

RECRUITING

Kyushu University Hospital, Fukuoka

701-1192

NOT_YET_RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

545-0051

NOT_YET_RECRUITING

Osaka Metropolitan University Hospital, Osaka

990-9585

RECRUITING

Yamagata University Hospital, Yamagata

3318 AT

RECRUITING

Albert Schweitzer Ziekenhuis, locatie Dordwijk, Dordrecht

50-367

ACTIVE_NOT_RECRUITING

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wroclaw

80-214

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

40-519

ACTIVE_NOT_RECRUITING

Pratia Onkologia Katowice, Katowice

03080

RECRUITING

Seoul National University Hospital, Seoul

06351

NOT_YET_RECRUITING

Samsung Medical Center, Seoul

06591

NOT_YET_RECRUITING

The Catholic Univ. of Korea Seoul St. Mary's Hospital(Seoul St. Mary's Hospital), Seoul

NOT_YET_RECRUITING

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul

08916

RECRUITING

Institut Català d'Oncologia (ICO) - Badalona, Badalona

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat

08036

RECRUITING

Hospital Clínic de Barcelona, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT05623020 - A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135), Daratumumab, Lenalidomide or Elranatamab and Lenalidomide Compared With Daratumumab, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant | Biotech Hunter | Biotech Hunter