800
Participants
Start Date
July 18, 2024
Primary Completion Date
June 30, 2027
Study Completion Date
June 30, 2028
Futibatinib
Dose 20 mg once a day (QD)
Ivosidenib
Dose 500 mg QD
Zanidatamab
Dose: Patients \< 70 kg: 1800 mg every 3 weeks (Q3W), Patients ≥ 70 kg: 2400 mg Q3W
Trastuzumab
Loading dose 8 mg/kg, then 6 mg/kg Q3W (Combination with neratinib)
Neratinib
Dose: 240 mg QD (combination with trastuzumab)
Encorafenib
Dose: 450 mg QD (Combination with binimetinib)
Binimetinib
Dose: 45 mg twice a day (BID) (Combination with encorafenib)
Niraparib
Dose: 200 mg QD or 300 mg QD
Cisplatin
Dose: 25 mg/m2 IV on days 1 and 8 Q3W (CISGEM)
Gemcitabine
Dose: 1000 mg/m2 IV on days 1 and 8 Q3W (CISGEM)
NOT_YET_RECRUITING
Cliniques universitaires de Bruxelles - Hôpital Erasme ULB, Brussels
NOT_YET_RECRUITING
Cliniques universitaires Saint-Luc, Brussels
NOT_YET_RECRUITING
Universitair Ziekenhuis Antwerpen (UZA), Edegem
NOT_YET_RECRUITING
Universitair Ziekenhuis Leuven, Leuven
RECRUITING
CHU Amiens Picardie, Amiens
RECRUITING
CHU d'Angers, Angers
RECRUITING
Institut de cancerologie de l'Ouest - Angers, Angers
RECRUITING
Institut du Cancer Avignon Provence, Avignon
RECRUITING
CHU de Besançon, Besançon
NOT_YET_RECRUITING
CHU de Bordeaux - Hôpital Haut-Leveque, Bordeaux
RECRUITING
Centre François Baclesse, Caen
RECRUITING
Centre Jean Perrin, Clermont-Ferrand
RECRUITING
CHU Estaing de Clermont Ferrand, Clermont-Ferrand
RECRUITING
APHP - Hopital Henri Mondor, Créteil
RECRUITING
CHU de Dijon, Dijon
NOT_YET_RECRUITING
CHU Grenoble Alpes, Grenoble
RECRUITING
Groupe hospitalier mutaliste de Grenoble - Institut Daniel Hollard, Grenoble
RECRUITING
Centre Oscar Lambret, Lille
RECRUITING
CHU Lille, Lille
RECRUITING
CHU Dupuytren, Limoges
NOT_YET_RECRUITING
Centre Leon Bérard, Lyon
NOT_YET_RECRUITING
Clinique Privée Jean Mermoz, Lyon
RECRUITING
Hospices Civils de Lyon - Croix Rousse, Lyon
NOT_YET_RECRUITING
APHM - CHU La Timone, Marseille
RECRUITING
Hôpital Européen, Marseille
RECRUITING
Institut Paoli Calmettes, Marseille
RECRUITING
Institut de Cancer de Montpellier, Montpellier
NOT_YET_RECRUITING
CHU Nantes - Hôtel Dieu, Nantes
RECRUITING
Centre Antoine Lacassagne, Nice
RECRUITING
APHP - Hôpital Beaujon, Paris
RECRUITING
APHP - Hôpital Cochin, Paris
RECRUITING
APHP - Hôpital Saint Antoine, Paris
NOT_YET_RECRUITING
Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris
RECRUITING
Institute Mutualiste Montsouris, Paris
RECRUITING
CH de Pau, Pau
RECRUITING
CHU Poitiers, Poitiers
RECRUITING
CH Cornouaille, Quimper
RECRUITING
CHU de Reims, Reims
RECRUITING
Institut Jean Godinot, Reims
RECRUITING
Centre Eugène Marquis, Rennes
NOT_YET_RECRUITING
CHU Charles Nicolle, Rouen
NOT_YET_RECRUITING
Institut Curie - Saint Cloud, Saint-Cloud
NOT_YET_RECRUITING
Institut de Cancerologie de l'Ouest, Saint-Herblain
RECRUITING
Hôpital Foch, Suresnes
RECRUITING
CHU Toulouse, Toulouse
RECRUITING
CH Valence, Valence
RECRUITING
CHRU de Nancy, Vandœuvre-lès-Nancy
NOT_YET_RECRUITING
APHP - Hôpital Paul Brousse, Villejuif
RECRUITING
Gustave Roussy, Villejuif
RECRUITING
Queen Elizabeth Hospital, Birmingham
RECRUITING
Bristol Haematology and Oncology Centre, Bristol
NOT_YET_RECRUITING
Addenbrooke's Hospital, Cambridge
NOT_YET_RECRUITING
Castle Hill Hospital, Cottingham
NOT_YET_RECRUITING
St James's Hospital, Leeds
NOT_YET_RECRUITING
Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool
NOT_YET_RECRUITING
Guy's & St Thomas' Hospital, London
RECRUITING
Hammersmith Hospital, London
NOT_YET_RECRUITING
Royal Free Hospital, London
RECRUITING
Royal Marsden Hospital, London
RECRUITING
University College London, London
NOT_YET_RECRUITING
Maidstone Hospital, Maidstone
NOT_YET_RECRUITING
The Christie Hospital, Manchester
RECRUITING
Mount Vernon Cancer Centre, Northwood
RECRUITING
Nottingham University Hospital, Nottingham
NOT_YET_RECRUITING
Churchill Hospital, Oxford
NOT_YET_RECRUITING
North West Anglia NHS Foundation Trust, Peterborough
NOT_YET_RECRUITING
Weston Park Cancer Centre, Sheffield
NOT_YET_RECRUITING
Southampton General Hospital, Southampton
NOT_YET_RECRUITING
Singleton Hospital, Swansea
Collaborators (2)
Cancer Research UK & UCL Cancer Trials Centre
OTHER
Belgian Group of Digestive Oncology
OTHER
National Cancer Institute, France
OTHER_GOV
Cancer Research UK
OTHER
Taiho Oncology, Inc.
INDUSTRY
Servier
INDUSTRY
Zymeworks BC Inc.
INDUSTRY
Accord Healthcare, Inc.
INDUSTRY
Pierre Fabre Medicament
INDUSTRY
UNICANCER
OTHER