1,478
Participants
Start Date
November 21, 2022
Primary Completion Date
August 8, 2024
Study Completion Date
June 9, 2025
Olezarsen
Olezarsen will be administered by SC injection.
Placebo
Olezarsen-matching placebo will be administered by SC injection.
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Rome
The Lipid Clinic (Oslo University Hospital), Oslo
Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD, Sofia
Clinexpert Kft., Budapest
MBAL National Cardiology Hospital, Sofia
University Multiprofile Hospital for Active Treatment Alexandrovska, Sofia
University Multiprofile Hospital for Active Treatment, Sofia
Medico Dental Center ISUL Tsaritsa Yoanna EOOD, Sofia
MHAT Sv. Ivan Rilski - 2003 OOD, Dupnitsa
Gentofte Hospital, Hellerup
University Multiprofile Hospital for Active Treatment Pulmed OOD, Plovdiv
OUH Svendborg Hospital, Svendborg
UMHAT Prof. Dr. Stoyan Kirkovich, Stara Zagora
Sydvestjysk Hospital, Esbjerg
SHATC Medica Cor EAD, Rousse
Godstrup Regional Hospital (Gødstrup), Herning
Aarhus University Hospital, Aarhus
Hospital de la Santa Creu i Sant Pau, Barcelona
Calle Villarroel 170, Barcelona
Viborg Regional Hospital, Viborg
Interna SK, s.r.o., Kardiologicka a interna ambulancia, Svidník
Hospital Germans Trias i Pujol, Badalona
Diagnostic Consultative Center Equita (DCC Equita), Varna
Specialized Hospital for Active Treatment of Cardiology, Varna
Hospital Universitario Reina Sofia, Córdoba
Hospital Abente y Lago, A Coruña
Green and Seidner Family Practice Associates, Lansdale
Endokrinologie Cerny Most s.r.o., Prague
ASST NORD MILANO-Ospedale Edoardo Bassini, Cinisello Balsamo
Carient Heart & Vascular, Manassas
Manassas Clinical Research Center, Manassas
Centro Cardiologico Monzino, Milan
ASST Grande Ospedale Metropolitano Niguarda, Milan
CHU Dijon Bourgogne - Hopital Francois Mitterrand, Dijon
Maryland Cardiovascular Specialists, Baltimore
Charleston Area Medical Center (CAMC) Clinical Trials Center, Charleston
Moses H. Cone Memorial Hospital, Greensboro
Hospital Clinico San Carlos, Madrid
Hospital Universitario Virgen de la Victoria, Málaga
Medical University of South Carolina (MUSC), Charleston
Main Street Physicians Care Waterway, Little River
OnSite Clinical Solutions, LLC, Rock Hill
Atlanta Heart Specialists, Tucker
Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar
Centricity Research, Columbus
St. Johns Center for Clinical Research, Saint Augustine
Progressive Medical Research, Port Orange
Global Research Associates, Homestead
Finlay Medical Research, Miami
Advanced Medical Research Institute (AMRI), Miami
De La Cruz Research Center, LL, Miami
Proactive Clinical Research, Oakland Park
Comprehensive Medical & Research Center, Plantation
Excel Clinical Medical Trials, Boca Raton
3Sync Research, Lake Worth
Finlay Medical Research - West Palm, Greenacres City
JSV Clinical Research Study, Inc, Tampa
Ocala Cardiovascular Research, Ocala
Suncoast Clinical Research, Inc. - New Port Richey, New Port Richey
Suncoast Clinical Research, Inc. - Palm Harbor, New Port Richey
Alabama Clinical Therapeutics, LLC Alabaster, Birmingham
Heart Center Research PC, Huntsville
Affinity Health Corp., Nashville
Tennessee Center for Clinical Trials, Tullahoma
The Jackson Clinic, Jackson
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola, Bologna
Norton Cardiovascular Associates, Louisville
Louisville Metabolic and Atherosclerosis Research Center, Louisville
Hospital Universitario Virgen Macarena, Seville
Hospital Universitario Virgen del Rocio, Seville
McConnell Heart Health Center, Columbus
Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna, Cona
Summit Research Group, LLC, Stow
Aultman Hospital Cardiology Clinical Trials, Canton
Cardiovascular Research of Northwest Indiana, LLC, Munster
Reid Hospital and Health Care Services, Richmond
Aa Mrc, Llc, Flint
Palm Research Center, Inc., Las Vegas
Mercy One Iowa Heart Center, West Des Moines
West Broadway Clinic, Council Bluffs
Monument Health Clinical Research, Rapid City
Health Concepts, Rapid City
Groupement de Cooperation Sanitaire (GCS) ELSAN - Polyclinique Vauban, Valenciennes
Clinical Investigation Specialists, Inc, Gurnee
Affinity Health, Park Ridge
Evanston Premier Healthcare Research LLC, Evanston
UNIVMED s.r.o. - Kardiologicka Ambulance, Brno
University of Kansas Medical Center (KUMC), Kansas City
GHM les Portes du Sud, Vénissieux
HCL Hopital Louis Pradel, Bron
Central Oklahoma Early Detection Center, Edmond
AP-HP Hopital Pitie-Salpetriere, Paris
Texas Institute of Cardiology, McKinney
Southern Endocrinology Associates, Mesquite
Baylor College of Medicine, Houston
Juno Research, LLC, Houston
FMC Science, Round Rock
Clinical Research of South Nevada, Las Vegas
Palm Research Center, Inc., Las Vegas
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone, Palermo
Cardiovascular Research Foundation of Southern California, Beverly Hills
Westside Medical Associates of Los Angeles, Beverly Hills
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance
Amicis Research, Northridge
Valley Clinical Trials, Inc., Northridge
Amicis Research Center, Santa Clarita
Amicis Research Center, Valencia
Metabolic Institute of America, Tarzana
University of California, San Diego (UCSD), La Jolla
Diabetes/Lipid Management & Research Center, Huntington Beach
Clinical Trials Research, Lincoln
Northern California Research, Sacramento
ARC Biosystems, Vancouver
Centricity Research - Vaughan Endocrinology, Concord
Centricity Research - Etobicoke Endocrinology, Etobicoke
Centricity Research - Oshawa Multispecialty, Oshawa
Bluewater Clinical Research Group Inc, Sarnia
Centricity Research - Toronto LMC Multispecialty, Toronto
Ecogene-21, Chicoutimi
Montreal Heart Institute - Institut de Cardiologie de Montreal, Montreal
Institute de Recherches Cliniques de Montreal, Montreal
Clinique des Maladies Lipidiques de Quebec Inc., Québec
Centricity Research - Barrie Endocrinology, Barrie
Centricity Research - Brampton Endocrinology, Brampton
Centre de Recherche Saint-Louis, Québec
Cevni ambulance - MATMED s.r.o., Hodonín
Edumed s.r.o., Kardiologicka, endokrinologicka, diabetologicka a interni ambulance Nachod, Jaroměř
Affidea Praha s.r.o., Prague
Diabetologicka a endokrinologicka ambulance Milan Kvapil s.r.o, Prague
AeskuLab k.s, Teplice
MUDr. Nina Zemkova s.r.o. Interni Ambulance, Uherské Hradiště
Obudai Egeszsegugyi Centrum, Budapest
CRU Hungary Kft., Encs
Academic Medical Center - Department of Vascular Medicine, Amsterdam
Ziekenhuis Rijnstate, Arnhem
Reinier de Graaf Gasthuis, Delft
Deventer Ziekenhuis, Deventer
Het Van Weel-Bethesda Ziekenhuis, Dirksland
Groene Hart Ziekenhuis, Gouda
Spaarne Gasthuis, Haarlem
Zuyderland Medisch Centrum, Heerlen
Bethesda Diabetes Research Center, Hoogeveen
Canisius-Wilhelmina Ziekenhuis (CWZ), Nijmegen
D&A Research, Sneek
Universitair Medisch Centrum Utrecht, Utrecht
Maxima Medisch Centrum, Veldhoven
Albert Schweitzer Ziekenhuis - Location Dordrecht, Zwijndrecht
Albert Schweitzer Ziekenhuis, Zwijndrecht
SALVIA Lekston i Madej s.j., Katowice
Jagiellonskie Centrum Innowacji Sp. z o.o., Krakow
Krakowskie Centrum Medyczne Sp. z o.o., Krakow
FutureMeds, Lodz
INSTYTUT CENTRUM ZDROWIA MATKI POLKI - Klinika Kardiologii i Wad Wrodzonych Doroslych, Lodz
Praktyka Lekarska Ewa Krzyzagorska, Poznan
FutureMeds Warszawa Centrum, Warsaw
Clinical Best Solutions Sp. z.o.o Spolka Komandytowa, Warsaw
FutureMeds - Centrum Medyczne AMED Warszawa Targowek, Warsaw
Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy, Klinika Kardiologii i Angiologii Interwencyjnej, Warsaw
FutureMeds Sp. z o.o, Wroclaw
Slaski Park Technologii Medycznych Kardio-Med Silesia Sp. z o. o, Zabrze
ETG Zamosc - Pro Life Medica Sp. z o.o, Zamość
Centro Hospitalar de Lisboa Ocidental. E.P.E, - Hospital Santa Cruz, Carnaxide
Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Egas Moniz, Lisbon
Centro Hospitalar Universitario de Lisboa Norte - Hospital de Santa Maria, Lisbon
Centro Hospitalar de Vila Nova de Gaia/Espinho EPE, Vila Nova de Gaia
Alian, s.r.o., Kardiologicka ambulancia, Bardejov
Cardio D&R, S.R.O. Kosice, Košice
Diab sro, Rožňava
Lead Sponsor
Ionis Pharmaceuticals, Inc.
INDUSTRY