Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

PHASE3RecruitingINTERVENTIONAL
Enrollment

614

Participants

Timeline

Start Date

February 6, 2023

Primary Completion Date

January 12, 2027

Study Completion Date

August 23, 2028

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
BIOLOGICAL

Sacituzumab Govitecan

IV infusion

BIOLOGICAL

Pembrolizumab

IV infusion

Trial Locations (179)

106

RECRUITING

National Taiwan University Cancer Center (NTUCC) ( Site 0079), Taipei City

402

COMPLETED

Chung Shan Medical University Hospital ( Site 0078), Taichung

704

COMPLETED

National Cheng Kung University Hospital-Clinical Trial Center ( Site 0076), Tainan City

1002

RECRUITING

Pauls Stradins Clinical Univeristy Hospital-Chemotherapy department ( Site 0192), Riga

1102

RECRUITING

ST. LUKE'S MEDICAL CENTER ( Site 0046), Quezon City

2800

RECRUITING

Orange Hospital-Clinical Trials Unit ( Site 0600), Orange

3199

RECRUITING

Frankston Hospital-Oncology and Haematology ( Site 0601), Frankston

5000

RECRUITING

Cancer Research SA-St Andrews Hospital ( Site 0603), Adelaide

5417

RECRUITING

Daugavpils Regional Hospital-Oncology Department ( Site 0194), Daugavpils

6000

RECRUITING

Cebu Doctors University Hospital ( Site 0045), Cebu

8000

RECRUITING

Metro Davao Medical and Research Center ( Site 0047), Davao City

10002

RECRUITING

National Taiwan University Hospital-Internal Medicine ( Site 0080), Taipei

10300

RECRUITING

Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 0097), Bangkok

10450

RECRUITING

Hospital Pulau Pinang-Oncology, radiotherapy and palliat ( Site 0034), George Town

10601

COMPLETED

White Plains Hospital-Center for Cancer Care ( Site 0403), White Plains

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 0090), Bangkok

11096

RECRUITING

Basil Clinical ( Site 0441), Inwood

12125

RECRUITING

Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 0362), Concepción

13001

RECRUITING

Centro de investigacion Clínica Trujillo ( Site 0358), Trujillo

13419

RECRUITING

North Estonia Medical Centre Foundation-Chemotherapy ( Site 0621), Tallinn

13585

RECRUITING

Vivantes Hospital Spandau-Klinik für Innere Medizin, Hämatologie, Onkologie und Gastroenterologie- ( Site 0656), Berlin

14165

RECRUITING

Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 0653), Berlin

15036

RECRUITING

Clinica Vallesur - AUNA ( Site 0360), Arequipa

ACTIVE_NOT_RECRUITING

Clínica Internacional - Sede San Borja ( Site 0356), Lima

15038

RECRUITING

Detecta Clínica ( Site 0364), Surquillo

15047

RECRUITING

Instituto Neuro Cardiovascular de las Americas ( Site 0365), Lima

15102

RECRUITING

Hospital Cayetano Heredia ( Site 0361), Lima

15586

RECRUITING

Hospital Raja Perempuan Zainab II-Medical Department ( Site 0035), Kota Bharu

20116

RECRUITING

Centro de Investigacion Medica Aguascalientes ( Site 0340), Aguascalientes

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0673), Milan

22010

RECRUITING

COI Tijuana - Centro Oncológico Internacional ( Site 0350), Tijuana

22030

RECRUITING

Trakya University-Medical Oncology ( Site 0270), Edirne

24127

RECRUITING

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII ( Site 0674), Bergamo

30060

COMPLETED

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 0407), Marietta

32763

RECRUITING

Mid Florida Hematology and Oncology Center ( Site 0416), Orange City

33136

COMPLETED

University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0417), Miami

33240

RECRUITING

Mersin Sehir Eğitim ve Araştırma Hastanesi ( Site 0275), Mersin

33305

RECRUITING

Chang Gung Medical Foundation-Linkou Branch ( Site 0082), Taoyuan District

34000

ACTIVE_NOT_RECRUITING

Sunpasitthiprasong Hospital ( Site 0093), Ubon Ratchathani

34711

COMPLETED

Clermont Oncology Center ( Site 0421), Clermont

34722

RECRUITING

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 0267), Istanbul

34899

RECRUITING

VM Medical Park Pendik Hospital ( Site 0271), Istanbul

35015

RECRUITING

Chungnam national university hospital-Department of Internal Medicine ( Site 0063), Daejeon

35575

RECRUITING

I.E.U. Medical Point Hastanesi-Oncology ( Site 0266), Izmir

36607

RECRUITING

Infirmary Cancer Care ( Site 0418), Mobile

37019

RECRUITING

Casa di Cura Dott. Pederzoli-LUNG-UNIT TORACIC ( Site 0670), Peschiera del Garda

40447

RECRUITING

China Medical University Hospital-Internal Medicine ( Site 0083), Taichung

43126

RECRUITING

Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 0676), Parma

46050

RECRUITING

Beacon Hospital Sdn Bhd ( Site 0033), Petaling Jaya

48202

COMPLETED

Henry Ford Hospital ( Site 0412), Detroit

48334

RECRUITING

Profound Research LLC ( Site 0440), Farmington Hills

50134

RECRUITING

Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 0675), Florence

50161

RECRUITING

Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 0692), Kaunas

50200

RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 0092), Muang

50406

RECRUITING

Tartu University Hospital-Radiotherapy and oncology ( Site 0620), Tartu

50612

RECRUITING

Pusan National University Yangsan Hospital ( Site 0060), Pusan

52000

RECRUITING

Lampang Cancer Hospital ( Site 0098), Lampang

55407

RECRUITING

Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0425), Minneapolis

56073

RECRUITING

Katholisches Klinikum Koblenz ( Site 0650), Koblenz

58128

RECRUITING

Chonnam National University Hwasun Hospital-Pulmonology ( Site 0061), Hwasun

64460

RECRUITING

"Hospital Universitario Dr. Jose Eleuterio Gonzalez-Servicio de Oncología ( Site 0352)", Monterrey

68000

RECRUITING

Oaxaca Site Management Organization ( Site 0346), Oaxaca City

68020

RECRUITING

Centro de Investigacion Clinica de Oaxaca ( Site 0351), Oaxaca City

68167

RECRUITING

Universitätsmedizin Mannheim ( Site 0654), Mannheim

70808

RECRUITING

Our Lady of the Lake RMC ( Site 0424), Baton Rouge

76504

COMPLETED

Central Texas Veterans health care ( Site 0414), Temple

77030

RECRUITING

Houston Methodist Hospital ( Site 0419), Houston

80131

RECRUITING

Azienda Ospedaliera Dei Colli-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 0671), Naples

82445

RECRUITING

E-Da hospital ( Site 0075), Kaohsiung City

87439

RECRUITING

Klinikum Kempten ( Site 0655), Kempten (Allgäu)

90110

RECRUITING

Songklanagarind hospital ( Site 0091), Hat Yai

97070

RECRUITING

Medical Care and Research SA de CV ( Site 0353), Mérida

97074

RECRUITING

Klinikum Würzburg Mitte ( Site 0651), Würzburg

97227

RECRUITING

Kaiser Permanente Northwest-Central Interstate--Oncology ( Site 0408), Portland

97239

RECRUITING

Oregon Health & Science University ( Site 0427), Portland

100142

ACTIVE_NOT_RECRUITING

Beijing Cancer hospital ( Site 0104), Beijing

100730

ACTIVE_NOT_RECRUITING

Beijing Peking Union Medical College Hospital-pneumology department ( Site 0106), Beijing

101149

ACTIVE_NOT_RECRUITING

Beijing Chest Hospital,Capital Medical University ( Site 0105), Beijing

130021

ACTIVE_NOT_RECRUITING

The First Hospital of Jilin University ( Site 0117), Changchun

130103

ACTIVE_NOT_RECRUITING

Jilin Province Tumor Hospital-clinical research ( Site 0118), Changchun

150081

ACTIVE_NOT_RECRUITING

Harbin Medical University Cancer Hospital ( Site 0119), Harbin

200030

ACTIVE_NOT_RECRUITING

Shanghai Chest Hospital ( Site 0101), Shanghai

200032

ACTIVE_NOT_RECRUITING

Fudan University Shanghai Cancer Center-Oncology ( Site 0102), Shanghai

200040

ACTIVE_NOT_RECRUITING

Huashan Hospital, Fudan University ( Site 0103), Shanghai

200542

RECRUITING

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 0215), Craiova

210008

RECRUITING

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 0112), Nanjing

215000

ACTIVE_NOT_RECRUITING

The First Affliated Hospital of Suzhou University ( Site 0114), Suzhou

226361

COMPLETED

Nantong Tumor Hospital-Medical Oncology ( Site 0122), Nantong

230000

ACTIVE_NOT_RECRUITING

Second Affiliated hospital of Anhui Medical University ( Site 0126), Hefei

230071

RECRUITING

Anhui Provincial Hospital ( Site 0136), Hefei

250013

ACTIVE_NOT_RECRUITING

Jinan Central Hospital-oncology department ( Site 0121), Jinan

276034

ACTIVE_NOT_RECRUITING

LinYi Cancer Hospital ( Site 0120), Linyi

300239

RECRUITING

Cabinet Medical Oncomed ( Site 0219), Timișoara

310006

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital, Zhejiang University ( Site 0109), Hangzhou

310009

ACTIVE_NOT_RECRUITING

The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0110), Hangzhou

310016

ACTIVE_NOT_RECRUITING

Sir Run Run Shaw Hospital-Medical Oncology ( Site 0111), Hangzhou

310022

ACTIVE_NOT_RECRUITING

Zhejiang Cancer Hospital ( Site 0108), Hangzhou

330006

ACTIVE_NOT_RECRUITING

The Second Affiliated Hospital of Nanchang University ( Site 0134), Nanchang

350014

ACTIVE_NOT_RECRUITING

Fujian Provincial Cancer Hospital ( Site 0131), Fuzhou

361003

ACTIVE_NOT_RECRUITING

The First Affiliated hospital of Xiamen University ( Site 0132), Xiamen

400015

RECRUITING

Cardiomed SRL Cluj-Napoca ( Site 0217), Cluj-Napoca

RECRUITING

Institutul Oncologic-Oncologie Medicala ( Site 0218), Cluj-Napoca

400030

ACTIVE_NOT_RECRUITING

Chongqing University Cancer Hospital-Medical Oncology ( Site 0130), Chongqing

407280

RECRUITING

Amethyst Radiotherapy Center-Oncologie Medicala ( Site 0216), Florești

410008

ACTIVE_NOT_RECRUITING

Xiangya Hospital Central South University ( Site 0124), Changsha

410011

ACTIVE_NOT_RECRUITING

The Second Xiangya Hospital of Central South University ( Site 0135), Changsha

430000

ACTIVE_NOT_RECRUITING

Tongji Hospital Tongji Medical,Science & Technology ( Site 0116), Wuhan

430048

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0115), Wuhan

430079

RECRUITING

Hubei Cancer Hospital ( Site 0107), Wuhan

450008

COMPLETED

Henan Cancer Hospital ( Site 0127), Zhengzhou

510515

ACTIVE_NOT_RECRUITING

Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 0125), Guangzhou

530021

RECRUITING

Affiliated Cancer Hospital of Guangxi Medical University ( Site 0113), Nanning

610041

ACTIVE_NOT_RECRUITING

West China Hospital of Sichuan University ( Site 0129), Chengdu

610213

ACTIVE_NOT_RECRUITING

Sichuan Cancer hospital. ( Site 0128), Chengdu

710061

COMPLETED

The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0133), Xi'an

4428164

COMPLETED

Meir Medical Center-oncology ( Site 0171), KfarSaba

4941492

RECRUITING

Rabin Medical Center-Oncology ( Site 0174), Petah Tikva

6423906

RECRUITING

Sourasky Medical Center-Oncology ( Site 0175), Tel Aviv

7033001

RECRUITING

Yitzhak Shamir Medical Center. ( Site 0179), Ẕerifin

7500994

RECRUITING

Oncovida ( Site 0334), Santiago

8330024

RECRUITING

Pontificia Universidad Catolica de Chile ( Site 0332), Santiago

9103102

RECRUITING

Shaare Zedek Medical Center-Oncology ( Site 0176), Jerusalem

14784400

RECRUITING

Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0318), Barretos

92056-4522

RECRUITING

Profound Research LLC ( Site 0444), Oceanside

60336-232

RECRUITING

CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 0320), Fortaleza

95700-068

RECRUITING

Hospital Tacchini ( Site 0322), Bento Gonçalves

99010-260

RECRUITING

Hospital da Cidade de Passo Fundo ( Site 0321), Passo Fundo

96830-180

RECRUITING

Instituto de Oncologia Saint Gallen ( Site 0317), Santa Cruz do Sul

01509-010

RECRUITING

A. C. Camargo Cancer Center ( Site 0324), São Paulo

V2S 0C2

RECRUITING

BC Cancer Abbotsford-Medical Oncology ( Site 0433), Abbotsford

L3Y 2P9

RECRUITING

Southlake Regional Health Centre-Oncology Clinical Trials ( Site 0435), Newmarket

J4V 2H1

RECRUITING

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0430), Greenfield Park

H3T 1M5

RECRUITING

St. Marys Hospital Center-Oncology ( Site 0434), Montreal

G8Z 3R9

RECRUITING

Centre integre universitaire de sante et de services sociaux-oncology ( Site 0431), Trois-Rivières

06120

RECRUITING

Krankenhaus Martha-Maria Halle-Dölau-Klinik für Innere Medizin II ( Site 0657), Halle

115 26

RECRUITING

Errikos Dunant Hospital Center-Fourth Department of Oncology and Clinical Trials Unit ( Site 0141), Athens

115 27

RECRUITING

Sotiria Thoracic Diseases Hospital of Athens-3rd Dept of Internal Medicine, Oncology Unit ( Site 0140), Athens

570 01

RECRUITING

European Interbalkan Medical Center-Oncology Department ( Site 0142), Thessaloniki

00184

RECRUITING

Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 0677), Rome

464-8681

RECRUITING

Aichi Cancer Center ( Site 0018), Nagoya

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center ( Site 0008), Matsuyama

830-0011

RECRUITING

Kurume University Hospital ( Site 0014), Kurume

665-0827

RECRUITING

Takarazuka City Hospital ( Site 0015), Takarazuka

920-8641

RECRUITING

Kanazawa University Hospital ( Site 0019), Kanazawa

241-8515

RECRUITING

Kanagawa Cancer Center ( Site 0016), Yokohama

981-1293

RECRUITING

Miyagi Cancer Center ( Site 0001), Natori-shi

981-0914

RECRUITING

Sendai Kousei Hospital ( Site 0012), Sendai

951-8566

RECRUITING

Niigata Cancer Center Hospital ( Site 0017), Niigata

710-8602

RECRUITING

Kurashiki Central Hospital ( Site 0011), Kurashiki

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 0005), Hirakata

589-8511

RECRUITING

Kindai University Hospital ( Site 0013), Sayama

362-0806

RECRUITING

Saitama Prefectural Cancer Center ( Site 0002), Kitaadachi-gun

411-8777

RECRUITING

Shizuoka Cancer Center ( Site 0004), Nagaizumi-cho,Sunto-gun

113-8677

RECRUITING

Tokyo Metropolitan Komagome Hospital ( Site 0020), Bunkyo Ku

810-8563

RECRUITING

National Hospital Organization Kyushu Medical Center ( Site 0009), Fukuoka

812-8582

RECRUITING

Kyushu University Hospital ( Site 0010), Fukuoka

700-8558

RECRUITING

Okayama University Hospital ( Site 0007), Okayama

113-8603

RECRUITING

Nippon Medical School Hospital ( Site 0003), Tokyo

641-8510

RECRUITING

Wakayama Medical University Hospital ( Site 0006), Wakayama

LV-3414

COMPLETED

Liepjas reionl slimnca ( Site 0191), Liepāja

LV1079

RECRUITING

RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of Ch ( Site 0193), Riga

LT-08406

RECRUITING

Vilnius University Hospital Santaros Clinics Affiliate - National Cancer Center ( Site 0691), Vilnius

60-693

RECRUITING

Med-Polonia Sp. z o. o. ( Site 0204), Poznan

85-796

RECRUITING

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 0208), Bydgoszcz

08-110

RECRUITING

Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 0201), Siedlce

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 0200), Warsaw

37-700

ACTIVE_NOT_RECRUITING

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 0203), Przemyśl

82-550

RECRUITING

Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 0202), Prabuty

47-400

RECRUITING

Szpital Rejonowy im. dr. J. Rostka w Raciborzu ( Site 0207), Racibórz

031422

RECRUITING

Gral Medical SRL-Medical Oncology ( Site 0220), Bucharest

05505

RECRUITING

Asan Medical Center ( Site 0064), Seoul

Unknown

RECRUITING

Korea University Guro Hospital-Internal Medicine ( Site 0062), Seoul

06230

RECRUITING

Hacettepe Universite Hastaneleri-oncology hospital ( Site 0265), Ankara

06680

RECRUITING

Liv Hospital Ankara-Oncology ( Site 0274), Ankara

06800

RECRUITING

Ankara City Hospital-Medical Oncology ( Site 0268), Ankara

LE1 5WW

RECRUITING

Leicester Royal Infirmary-HOPE Clinical Trials Unit ( Site 0300), Leicester

EC1A 7BE

RECRUITING

St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 0302), London

NW1 2PG

COMPLETED

University College London Hospital ( Site 0305), London

CH63 4JY

RECRUITING

The Clatterbridge Cancer Centre ( Site 0303), Metropolitan Borough of Wirral

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT05609968 - Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46) | Biotech Hunter | Biotech Hunter