Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

398

Participants

Timeline

Start Date

June 1, 2023

Primary Completion Date

August 15, 2025

Study Completion Date

February 15, 2028

Conditions
Metastatic Non-Small Cell Lung CancerAdvanced Non-Small Cell Lung CancerEGFR Exon 20 Mutations
Interventions
DRUG

furmonertinib 240 mg oral, daily

furmonertinib tablet

DRUG

furmonertinib 160 mg oral, daily

furmonertinib tablet

DRUG

platinum-based chemotherapy

(carboplatin or cisplatin based on investigator's choice) + pemetrexed intravenously (IV)

Trial Locations (208)

704

Arrivent Investigative Site, Tainan City

807

Arrivent Investigative Site, Kaohsiung City

1000

ArriVent Investigative Site, Manila

1600

Arrivent Investigative Site, Pasig

2148

Arrivent Investigative Site, Blacktown

2447

Arrivent Investigative Site, Seoul

3084

ArriVent Investigative Site, Heidelberg

3722

Arrivent Investigative Site, Seoul

4102

Arrivent Investigative Site, Woolloongabba

5505

Arrivent Investigative Site, Seoul

6000

Arrivent Investigative Site, Cebu

6351

Arrivent Investigative Site, Seoul

8000

Arrivent Investigative Site, Davao City

10048

Arrivent Investigative Site, Taipei

10210

Arrivent Investigative Site, Bangkok

10330

Arrivent Investigative Site, Bangkok

10400

Arrivent Investigative Site, Bangkok

10461

Arrivent Investigative Site, The Bronx

10990

ArriVent Investigative Site, George Town

13915

Arrivent Investigative Site, Marseille

14000

Arrivent Investigative Site, Caen

14080

ArriVent Investigative Site, Mexico City

15006

Arrivent Investigative Site, A Coruña

15586

Arrivent Investigative Site, Kota Bharu

17325

Arrivent Investigative Site, Gettysburg

17403

Arrivent Investigative Site, York

19047

ArriVent Investigative Site, Langhorne

20089

ArriVent Investigative Site, Rozzano

20141

ArriVent Investigative Site, Milan

20817

Arrivent Investigative Site, Bethesda

20850

Arrivent Investigative Site, Rockville

21702

Arrivent Investigative Site, Frederick

22031

ArriVent Investigative Site, Fairfax

22408

Arrivent Investigative Site, Fredericksburg

27534

Arrivent Investigative Site, Goldsboro

28020

ArriVent Investigative Site, Madrid

28374

ArriVent Investigative Site, Pinehurst

29011

ArriVent Investigative Site, Málaga

29038

ArriVent Investigative Site, Tuxtla Gutiérrez

29607

Arrivent Investigative Site, Greenville

31059

Arrivent Investigative Site, Toulouse

32159

Arrivent Investigative Site, The Villages

33081

ArriVent Investigative Site, Aviano

33705

Arrivent Investigative Site, St. Petersburg

33901

Arrivent Investigative Site, Fort Myers

36526

Arrivent Investigative Site, Daphne

37203

ArriVent Investigative Site, Nashville

38120

Arrivent Investigative Site, Memphis

43214

Arrivent Investigative Site, Columbus

44195

Arrivent Investigative Site, Cleveland

44708

Arrivent Investigative Site, Canton

45220

Arrivent Investigative Site, Cincinnati

45242

ArriVent Investigative Site, Cincinnati

46026

Arrivent Investigative Site, Valencia

46250

Arrivent Investigative Site, Indianapolis

46601

Arrivent Investigative Site, South Bend

46804

Arrivent Investigative Site, Fort Wayne

47014

Arrivent Investigative Site, Meldola

48912

Arrivent Investigative Site, Lansing

49241

Arrivent Investigative Site, Busan

50006

Arrivent Investigative Site, Chang-hua

50586

Arrivent Investigative Site, Kuala Lumpur

54911

Arrivent Investigative Site, Appleton

56000

Arrivent Investigative Site, Cheras

57117

Arrivent Investigative Site, Sioux Falls

58128

Arrivent Investigative Site, Hwasun

60008

Arrivent Investigative Site, Rolling Meadows

61615

Arrivent Investigative Site, Peoria

63110

Arrivent Investigative Site, St Louis

64111

Arrivent Investigative Site, Kansas City

64507

Arrivent Investigative Site, Saint Joseph

65613

Arrivent Investigative Site, Bolivar

68114

Arrivent Investigative Site, Omaha

69003

Arrivent Investigative Site, Lyon

69008

Arrivent Investigative Site, Lyon

70124

ArriVent Investigative Site, Bari

72703

Arrivent Investigative Site, Fayetteville

73102

Arrivent Investigative Site, Oklahoma City

74146

Arrivent Investigative Site, Tulsa

75093

Arrivent Investigative Site, Plano

77030

Arrivent Investigative Site, Houston

78745

ArriVent Investigative Site, Austin

79606

Arrivent Investigative Site, Abilene

82445

ArriVent Investigative Site, Kaohsiung City

84106

Arrivent Investigative Site, Salt Lake City

84405

Arrivent Investigative Site, Ogden

85364

Arrivent Investigative Site, Yuma

90110

Arrivent Investigative Site, Hat Yai

90212

Arrivent Investigative Site, Beverly Hills

90404

Arrivent Investigative Site, Santa Monica

90602

Arrivent Investigative Site, Whittier

90720

Arrivent Investigative Site, Los Alamitos

90806

Arrivent Investigative Site, Long Beach

90868

Arrivent Investigative Site, Orange

92123

Arrivent Investigative Site, San Diego

92835

Arrivent Investigative Site, Fullerton

92868

Arrivent Investigative Site, Orange

93105

Arrivent Investigative Site, Santa Barbara

93586

Arrivent Investigative Site, Kuching

94558

Arrivent Investigative Site, Napa

94800

Arrivent Investigative Site, Villejuif

95403

Arrivent Investigative Site, Santa Rosa

95817

Arrivent Investigative site, Sacramento

97301

Arrivent Investigative Site, Salem

98225

Arrivent Investigative Site, Bellingham

98405

Arrivent Investigative Site, Tacoma

99216

Arrivent Investigative Site, Spokane Valley

101149

Allist Investigative Site, Beijing

110042

Allist Investigative Site, Shenyang

119074

ArriVent Investigative Site, Singapore

130000

Allist Investigative Site, Changchun

Allist Investigative Site, Changchun

150081

Allist Investigative Site, Harbin

169610

Arrivent Investigative Site, Singapore

200030

Allist Investigative Site, Xuhui

200434

Allist Investigative Site, Shanghai

201321

Allist Investigative Site, Yangpu

210009

Allist Investigative Site, Nanjing

221009

Allist Investigative Site, Xuzhou

223300

Allist Investigative Site, Huai'an

230022

Allist Investigative Site, Shushan

230088

Allist Investigative Site, Hefei

250013

Allist Investigative Site, Jinan

250117

Allist Investigative Site, Jinan

264200

Allist Investigative Site, Weihai

272000

Allist Investigative Site, Jining

300061

Allist Investigative Site, Tianjin

310018

Allist Investigative Site, Hangzhou

310022

Allist Investigative Site, Zhejiang

315040

Allist Investigative Site, Ningbo

323020

Allist Investigative Site, Lishui

330006

Allist Investigative Site, Nanchang

330046

Allist Investigative Site, Nanchang

361000

Allist Investigative Site, Xiamen

400030

Allist Investigative Site, Chongqing

407219

ArriVent Investigative Site, Taichung

410008

Allist Investigative Site, Changsha

410031

Allist Investigative Site, Changsha

423099

Allist Investigative Site, Chenzhou

430023

Allist Investigative Site, Wuhan

441138

Allist Investigative Site, Xianyang

450003

Allist Investigative Site, Zhengzhou

450052

Allist Investigative Site, Zhengzhou

453000

Allist Investigative Site, Weihui

Allist Investigative Site, Xinxiang

455001

Allist Investigative Site, Anyang

471000

Allist Investigative Site, Luoyang

510062

Allist Investigative Site, Guangzhou

510285

Allist Investigative Site, Guangzhou

514000

Allist Investigative Site, Meizhou

515031

Allist Investigative Site, Shantou

516000

Allist Investigative Site, Huizhou

518001

Allist Investigative Site, Shenzhen

530000

Allist Investigative Site, Nanning

610041

Allist Investigative Site, Chengdu

650100

Allist Investigative Site, Kunming

710061

Allist Investigative Site, Xi’an

730030

Allist Investigative Site, Lanzhou

3109601

ArriVent Investigative Site, Haifa

4118777

Arrivent Investigative Site, Shizuoka

8410101

ArriVent Investigative Site, Beersheba

9103102

ArriVent Investigative Site, Jerusalem

06102

Arrivent Investigative Site, Hartford

06360

Arrivent Investigative Site, Norwich

02719

Arrivent Investigative Site, Fairhaven

07109

Arrivent Investigative Site, Belleville

07631

Arrivent Investigative Site, Englewood

07932

Arrivent Investigative Site, Florham Park

NSW 2065

Arrivent Investigative Site, St Leonards

40170-110

ArriVent Investigative Site, Salvador

30130-090

ArriVent Investigative Site, Belo Horizonte

20231-050

ArriVent Investigative Site, Rio de Janeiro

22281-100

ArriVent Investigative Site, Rio de Janeiro

96020-080

ArriVent Investigative Site, Pelotas

90035-903

ArriVent Investigative Site, Porto Alegre

89015-200

ArriVent Investigative Site, Blumenau

15090-000

ArriVent Investigative Site, São José do Rio Preto

01321-001

ArriVent Investigative Site, São Paulo

01509-010

ArriVent Investigative Site, Liberdade

12030-200

ArriVent Investigative Site, Taubaté

91350-200

ArriVent Investigative Site, Porto Alegre

T6G 1Z2

ArriVent Investigative Site, Edmonton

M5G 1Z5

ArriVent Investigative Site, Toronto

061011

Allist Investigative Site, Cangzhou

030013

Allist Investigative Site, Taiyuan

030000

Allist Investigative Site, Taiyuan

00144

ArriVent Investigative Site, Roma

830-0011

ArriVent Investigative Site, Kurume

673-8558

Arrivent Investigative Site, Akashi

573-1191

Arrivent Investigative Site, Hirakata

277-8577

Arrivent Investigative Site, Kashiwa

460-0001

Arrivent Investigative Site, Nagoya

589-8511

Arrivent Investigative Site, Ōsaka-sayama

003-0804

Arrivent Investigative Site, Sapporo

980-0873

Arrivent Investigative Site, Sendai

113-8431

Arrivent Investigative Site, Tokyo

113-8677

ArriVent Investigative Site, Tokyo

755-0241

Arrivent Investigative Site, Ube

241-8515

Arrivent Investigative Site, Yokohama

1066 CX

Arrivent Investigative Site, Amsterdam

3844DG

Arrivent Investigative Site, Harderwijk

03181

ArriVent Investigative Site, Jungni I Gu

08035

Arrivent Investigative Site, Barcelona

GU2 7XX

ArriVent Investigative Site, Guildford

CH63 4JY

Arrivent Investigative Site, Bebington

SW3 6JJ

ArriVent Investigative Site, London

M20 4BX

ArriVent Investigative Site, Manchester

SM2 5PT

ArriVent Investigative Site, Sutton

Sponsors
All Listed Sponsors
collaborator

Allist Pharmaceuticals, Inc.

INDUSTRY

lead

ArriVent BioPharma, Inc.

INDUSTRY

NCT05607550 - Study to Compare Furmonertinib to Platinum-Based Chemotherapy for Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations (FURVENT) | Biotech Hunter | Biotech Hunter