440
Participants
Start Date
August 24, 2023
Primary Completion Date
June 30, 2028
Study Completion Date
December 30, 2028
Biospecimen Collection
Undergo blood sample collection
Calaspargase Pegol
Given standard of care calaspargase pegol
Levocarnitine
Given PO or IV
Pegaspargase
Given standard of care pegaspargase
Quality-of-Life Assessment
Ancillary studies
RECRUITING
NYP/Weill Cornell Medical Center, New York
RECRUITING
Montefiore Medical Center-Einstein Campus, The Bronx
RECRUITING
Montefiore Medical Center-Weiler Hospital, The Bronx
RECRUITING
Children's Hospital at Montefiore, The Bronx
RECRUITING
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
New York Medical College, Valhalla
RECRUITING
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
RECRUITING
NYU Langone Hospital - Long Island, Mineola
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Albany Medical Center, Albany
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Penn State Children's Hospital, Hershey
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
Inova Fairfax Hospital, Falls Church
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
Children's Hospital of The King's Daughters, Norfolk
RECRUITING
Carilion Children's, Roanoke
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Carolinas Medical Center/Levine Cancer Institute, Charlotte
RECRUITING
Saint Francis Hospital, Greenville
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Prisma Health Greenville Memorial Hospital, Greenville
RECRUITING
Saint Francis Cancer Center, Greenville
RECRUITING
Prisma Health Cancer Institute - Eastside, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Memorial Health University Medical Center, Savannah
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
Nemours Children's Clinic - Pensacola, Pensacola
SUSPENDED
Sacred Heart Hospital, Pensacola
RECRUITING
University of Florida Health Science Center - Gainesville, Gainesville
RECRUITING
AdventHealth Orlando, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Nicklaus Children's Hospital, Miami
RECRUITING
Miami Cancer Institute, Miami
RECRUITING
Tampa General Hospital, Tampa
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
RECRUITING
Children's Hospital of Alabama, Birmingham
RECRUITING
The Children's Hospital at TriStar Centennial, Nashville
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
East Tennessee Childrens Hospital, Knoxville
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
University of Kentucky/Markey Cancer Center, Lexington
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
RECRUITING
Rainbow Babies and Childrens Hospital, Cleveland
RECRUITING
Cleveland Clinic Foundation, Cleveland
RECRUITING
Children's Hospital Medical Center of Akron, Akron
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Dayton Children's Hospital, Dayton
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
RECRUITING
C S Mott Children's Hospital, Ann Arbor
RECRUITING
University of Michigan Comprehensive Cancer Center, Ann Arbor
RECRUITING
Children's Hospital of Michigan, Detroit
ACTIVE_NOT_RECRUITING
Michigan State University, East Lansing
RECRUITING
Bronson Methodist Hospital, Kalamazoo
RECRUITING
West Michigan Cancer Center, Kalamazoo
RECRUITING
Beacon Kalamazoo Cancer Center, Kalamazoo
RECRUITING
Bronson Battle Creek, Battle Creek
RECRUITING
Beacon Kalamazoo, Kalamazoo
RECRUITING
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
RECRUITING
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
RECRUITING
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
RECRUITING
Trinity Health Muskegon Hospital, Muskegon
RECRUITING
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores
RECRUITING
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
RECRUITING
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
Trinity Health Grand Rapids Hospital, Grand Rapids
RECRUITING
University of Michigan Health - West, Wyoming
RECRUITING
Corewell Health Reed City Hospital, Reed City
RECRUITING
Munson Medical Center, Traverse City
RECRUITING
Blank Children's Hospital, Des Moines
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
RECRUITING
Aurora Health Care Germantown Health Center, Germantown
RECRUITING
Aurora Cancer Care-Grafton, Grafton
RECRUITING
Aurora Medical Center in Summit, Summit
RECRUITING
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan
RECRUITING
Aurora Cancer Care-Southern Lakes VLCC, Burlington
RECRUITING
Aurora Saint Luke's South Shore, Cudahy
RECRUITING
Aurora Cancer Care-Kenosha South, Kenosha
RECRUITING
Aurora Cancer Care-Milwaukee, Milwaukee
RECRUITING
Aurora Saint Luke's Medical Center, Milwaukee
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
RECRUITING
Aurora Cancer Care-Milwaukee West, Wauwatosa
RECRUITING
Aurora West Allis Medical Center, West Allis
RECRUITING
Aurora Sinai Medical Center, Milwaukee
RECRUITING
Aurora Cancer Care-Racine, Racine
RECRUITING
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Aurora Bay Area Medical Group-Marinette, Marinette
RECRUITING
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers
RECRUITING
Aurora BayCare Medical Center, Green Bay
SUSPENDED
Marshfield Medical Center-Marshfield, Marshfield
RECRUITING
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Advocate Children's Hospital-Park Ridge, Park Ridge
RECRUITING
Advocate Children's Hospital-Oak Lawn, Oak Lawn
RECRUITING
Northwestern University, Chicago
RECRUITING
University of Illinois, Chicago
RECRUITING
University of Chicago Comprehensive Cancer Center, Chicago
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
University of Kansas Cancer Center, Kansas City
RECRUITING
University of Kansas Hospital-Westwood Cancer Center, Westwood
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
RECRUITING
Ochsner Medical Center Jefferson, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa
RECRUITING
Medical City Dallas Hospital, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Cook Children's Medical Center, Fort Worth
RECRUITING
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
RECRUITING
M D Anderson Cancer Center, Houston
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
Methodist Children's Hospital of South Texas, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Driscoll Children's Hospital, Corpus Christi
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
Covenant Children's Hospital, Lubbock
RECRUITING
UMC Cancer Center / UMC Health System, Lubbock
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
RECRUITING
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
RECRUITING
Saint Luke's Cancer Institute - Fruitland, Fruitland
RECRUITING
Saint Luke's Cancer Institute - Meridian, Meridian
RECRUITING
Saint Luke's Cancer Institute - Nampa, Nampa
RECRUITING
Saint Luke's Cancer Institute - Boise, Boise
RECRUITING
Banner University Medical Center - Tucson, Tucson
RECRUITING
Kingman Regional Medical Center, Kingman
RECRUITING
Presbyterian Hospital, Albuquerque
RECRUITING
University of New Mexico Cancer Center, Albuquerque
RECRUITING
Hope Cancer Care of Nevada-Pahrump, Pahrump
RECRUITING
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
RECRUITING
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson
RECRUITING
OptumCare Cancer Care at Seven Hills, Henderson
RECRUITING
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
RECRUITING
GenesisCare USA - Henderson, Henderson
RECRUITING
Las Vegas Urology - Green Valley, Henderson
RECRUITING
Las Vegas Urology - Pebble, Henderson
RECRUITING
Urology Specialists of Nevada - Green Valley, Henderson
RECRUITING
Las Vegas Urology - Pecos, Las Vegas
RECRUITING
OptumCare Cancer Care at Charleston, Las Vegas
RECRUITING
University Medical Center of Southern Nevada, Las Vegas
RECRUITING
Hope Cancer Care of Nevada, Las Vegas
RECRUITING
Radiation Oncology Centers of Nevada Central, Las Vegas
RECRUITING
Urology Specialists of Nevada - Central, Las Vegas
RECRUITING
GenesisCare USA - Las Vegas, Las Vegas
RECRUITING
Sunrise Hospital and Medical Center, Las Vegas
RECRUITING
Las Vegas Urology - Sunset, Las Vegas
RECRUITING
Urology Specialists of Nevada - Southwest, Las Vegas
RECRUITING
Radiation Oncology Centers of Nevada Southeast, Las Vegas
RECRUITING
Ann M Wierman MD LTD, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
RECRUITING
GenesisCare USA - Vegas Tenaya, Las Vegas
RECRUITING
Las Vegas Urology - Cathedral Rock, Las Vegas
RECRUITING
Las Vegas Urology - Smoke Ranch, Las Vegas
RECRUITING
OptumCare Cancer Care at MountainView, Las Vegas
RECRUITING
Urology Specialists of Nevada - Northwest, Las Vegas
RECRUITING
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
RECRUITING
Summerlin Hospital Medical Center, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada, Las Vegas
RECRUITING
GenesisCare USA - Fort Apache, Las Vegas
RECRUITING
OptumCare Cancer Care at Fort Apache, Las Vegas
RECRUITING
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
RECRUITING
Renown Regional Medical Center, Reno
RECRUITING
Saint Mary's Regional Medical Center, Reno
RECRUITING
Radiation Oncology Associates, Reno
RECRUITING
Carson Tahoe Regional Medical Center, Carson City
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
Kaiser Permanente Los Angeles Medical Center, Los Angeles
RECRUITING
Kaiser Permanente Downey Medical Center, Downey
RECRUITING
Kaiser Permanente-Bellflower, Bellflower
RECRUITING
Miller Children's and Women's Hospital Long Beach, Long Beach
RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
Kaiser Permanente-San Diego Mission, San Diego
RECRUITING
Kaiser Permanente-San Diego Zion, San Diego
RECRUITING
Kaiser Permanente-Fontana, Fontana
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Kaiser Permanente-Anaheim, Anaheim
RECRUITING
PCR Oncology, Arroyo Grande
RECRUITING
Valley Children's Hospital, Madera
RECRUITING
UCSF Medical Center-Mission Bay, San Francisco
RECRUITING
Stanford Cancer Institute Palo Alto, Palo Alto
RECRUITING
UCSF Benioff Children's Hospital Oakland, Oakland
RECRUITING
Sutter Medical Center Sacramento, Sacramento
RECRUITING
Kapiolani Medical Center for Women and Children, Honolulu
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Valley Medical Center, Renton
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Mary Bridge Children's Hospital and Health Center, Tacoma
RECRUITING
Madigan Army Medical Center, Tacoma
RECRUITING
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Providence Alaska Medical Center, Anchorage
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Maine Children's Cancer Program, Scarborough
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Newark Beth Israel Medical Center, Newark
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
SUSPENDED
IWK Health Centre, Halifax
SUSPENDED
Children's Hospital, London
SUSPENDED
Hospital for Sick Children, Toronto
Children's Oncology Group
NETWORK