Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma

PHASE3RecruitingINTERVENTIONAL
Enrollment

440

Participants

Timeline

Start Date

August 24, 2023

Primary Completion Date

June 30, 2028

Study Completion Date

December 30, 2028

Conditions
B Acute Lymphoblastic LeukemiaB Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1B Acute Lymphoblastic Leukemia, BCR-ABL1-LikeLymphoblastic LymphomaMixed Phenotype Acute LeukemiaT Acute Lymphoblastic Leukemia
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Calaspargase Pegol

Given standard of care calaspargase pegol

DIETARY_SUPPLEMENT

Levocarnitine

Given PO or IV

DRUG

Pegaspargase

Given standard of care pegaspargase

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (221)

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

10461

RECRUITING

Montefiore Medical Center-Einstein Campus, The Bronx

RECRUITING

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

RECRUITING

Children's Hospital at Montefiore, The Bronx

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

10595

RECRUITING

New York Medical College, Valhalla

11040

RECRUITING

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

12208

RECRUITING

Albany Medical Center, Albany

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

RECRUITING

Penn State Children's Hospital, Hershey

17822

RECRUITING

Geisinger Medical Center, Danville

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22042

RECRUITING

Inova Fairfax Hospital, Falls Church

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

24014

RECRUITING

Carilion Children's, Roanoke

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

29601

RECRUITING

Saint Francis Hospital, Greenville

29605

RECRUITING

BI-LO Charities Children's Cancer Center, Greenville

RECRUITING

Prisma Health Greenville Memorial Hospital, Greenville

29607

RECRUITING

Saint Francis Cancer Center, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

31404

RECRUITING

Memorial Health University Medical Center, Savannah

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32504

RECRUITING

Nemours Children's Clinic - Pensacola, Pensacola

SUSPENDED

Sacred Heart Hospital, Pensacola

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

32803

RECRUITING

AdventHealth Orlando, Orlando

32827

RECRUITING

Nemours Children's Hospital, Orlando

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33155

RECRUITING

Nicklaus Children's Hospital, Miami

33176

RECRUITING

Miami Cancer Institute, Miami

33606

RECRUITING

Tampa General Hospital, Tampa

33607

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33701

RECRUITING

Johns Hopkins All Children's Hospital, St. Petersburg

33908

RECRUITING

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

37203

RECRUITING

The Children's Hospital at TriStar Centennial, Nashville

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

37916

RECRUITING

East Tennessee Childrens Hospital, Knoxville

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40202

RECRUITING

Norton Children's Hospital, Louisville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43205

RECRUITING

Nationwide Children's Hospital, Columbus

43606

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44106

RECRUITING

Rainbow Babies and Childrens Hospital, Cleveland

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

44308

RECRUITING

Children's Hospital Medical Center of Akron, Akron

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

RECRUITING

Dayton Children's Hospital, Dayton

46202

RECRUITING

Riley Hospital for Children, Indianapolis

46260

RECRUITING

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

RECRUITING

Children's Hospital of Michigan, Detroit

48823

ACTIVE_NOT_RECRUITING

Michigan State University, East Lansing

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

RECRUITING

West Michigan Cancer Center, Kalamazoo

49009

RECRUITING

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

RECRUITING

Bronson Battle Creek, Battle Creek

49048

RECRUITING

Beacon Kalamazoo, Kalamazoo

49085

RECRUITING

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

RECRUITING

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

RECRUITING

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

RECRUITING

Trinity Health Muskegon Hospital, Muskegon

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

RECRUITING

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49677

RECRUITING

Corewell Health Reed City Hospital, Reed City

49684

RECRUITING

Munson Medical Center, Traverse City

50309

RECRUITING

Blank Children's Hospital, Des Moines

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

RECRUITING

Aurora Saint Luke's South Shore, Cudahy

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Children's Hospital of Wisconsin, Milwaukee

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54449

SUSPENDED

Marshfield Medical Center-Marshfield, Marshfield

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

60068

RECRUITING

Advocate Children's Hospital-Park Ridge, Park Ridge

60453

RECRUITING

Advocate Children's Hospital-Oak Lawn, Oak Lawn

60611

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

University of Illinois, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

63141

RECRUITING

Mercy Hospital Saint Louis, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70118

RECRUITING

Children's Hospital New Orleans, New Orleans

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

74136

RECRUITING

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa

75230

RECRUITING

Medical City Dallas Hospital, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

M D Anderson Cancer Center, Houston

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78229

RECRUITING

Methodist Children's Hospital of South Texas, San Antonio

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78411

RECRUITING

Driscoll Children's Hospital, Corpus Christi

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

79410

RECRUITING

Covenant Children's Hospital, Lubbock

79415

RECRUITING

UMC Cancer Center / UMC Health System, Lubbock

79905

RECRUITING

El Paso Children's Hospital, El Paso

80045

RECRUITING

Children's Hospital Colorado, Aurora

80218

RECRUITING

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver

83301

RECRUITING

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

RECRUITING

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

RECRUITING

Saint Luke's Cancer Institute - Meridian, Meridian

83687

RECRUITING

Saint Luke's Cancer Institute - Nampa, Nampa

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

86401

RECRUITING

Kingman Regional Medical Center, Kingman

87106

RECRUITING

Presbyterian Hospital, Albuquerque

RECRUITING

University of New Mexico Cancer Center, Albuquerque

89048

RECRUITING

Hope Cancer Care of Nevada-Pahrump, Pahrump

89052

RECRUITING

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

RECRUITING

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89074

RECRUITING

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

RECRUITING

GenesisCare USA - Henderson, Henderson

RECRUITING

Las Vegas Urology - Green Valley, Henderson

RECRUITING

Las Vegas Urology - Pebble, Henderson

RECRUITING

Urology Specialists of Nevada - Green Valley, Henderson

RECRUITING

Las Vegas Urology - Pecos, Las Vegas

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

RECRUITING

University Medical Center of Southern Nevada, Las Vegas

89103

RECRUITING

Hope Cancer Care of Nevada, Las Vegas

89106

RECRUITING

Radiation Oncology Centers of Nevada Central, Las Vegas

RECRUITING

Urology Specialists of Nevada - Central, Las Vegas

89109

RECRUITING

GenesisCare USA - Las Vegas, Las Vegas

RECRUITING

Sunrise Hospital and Medical Center, Las Vegas

89113

RECRUITING

Las Vegas Urology - Sunset, Las Vegas

RECRUITING

Urology Specialists of Nevada - Southwest, Las Vegas

89119

RECRUITING

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89128

RECRUITING

Ann M Wierman MD LTD, Las Vegas

RECRUITING

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

RECRUITING

GenesisCare USA - Vegas Tenaya, Las Vegas

RECRUITING

Las Vegas Urology - Cathedral Rock, Las Vegas

RECRUITING

Las Vegas Urology - Smoke Ranch, Las Vegas

RECRUITING

OptumCare Cancer Care at MountainView, Las Vegas

RECRUITING

Urology Specialists of Nevada - Northwest, Las Vegas

89135

RECRUITING

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89144

RECRUITING

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

RECRUITING

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

RECRUITING

Summerlin Hospital Medical Center, Las Vegas

89148

RECRUITING

Comprehensive Cancer Centers of Nevada, Las Vegas

RECRUITING

GenesisCare USA - Fort Apache, Las Vegas

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

89169

RECRUITING

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

89502

RECRUITING

Renown Regional Medical Center, Reno

89503

RECRUITING

Saint Mary's Regional Medical Center, Reno

89509

RECRUITING

Radiation Oncology Associates, Reno

89703

RECRUITING

Carson Tahoe Regional Medical Center, Carson City

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90242

RECRUITING

Kaiser Permanente Downey Medical Center, Downey

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

90806

RECRUITING

Miller Children's and Women's Hospital Long Beach, Long Beach

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92108

RECRUITING

Kaiser Permanente-San Diego Mission, San Diego

92120

RECRUITING

Kaiser Permanente-San Diego Zion, San Diego

92335

RECRUITING

Kaiser Permanente-Fontana, Fontana

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

93420

RECRUITING

PCR Oncology, Arroyo Grande

93636

RECRUITING

Valley Children's Hospital, Madera

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

94609

RECRUITING

UCSF Benioff Children's Hospital Oakland, Oakland

95816

RECRUITING

Sutter Medical Center Sacramento, Sacramento

96826

RECRUITING

Kapiolani Medical Center for Women and Children, Honolulu

97239

RECRUITING

Oregon Health and Science University, Portland

98055

RECRUITING

Valley Medical Center, Renton

98105

RECRUITING

Seattle Children's Hospital, Seattle

98405

RECRUITING

Mary Bridge Children's Hospital and Health Center, Tacoma

98431

RECRUITING

Madigan Army Medical Center, Tacoma

98902

RECRUITING

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99204

RECRUITING

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

99508

RECRUITING

Providence Alaska Medical Center, Anchorage

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

04074

RECRUITING

Maine Children's Cancer Program, Scarborough

07601

RECRUITING

Hackensack University Medical Center, Hackensack

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

07503

RECRUITING

Saint Joseph's Regional Medical Center, Paterson

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

B3K 6R8

SUSPENDED

IWK Health Centre, Halifax

N6A 5W9

SUSPENDED

Children's Hospital, London

M5G 1X8

SUSPENDED

Hospital for Sick Children, Toronto

All Listed Sponsors
lead

Children's Oncology Group

NETWORK