A Study to Evaluate Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis

PHASE3CompletedINTERVENTIONAL
Enrollment

920

Participants

Timeline

Start Date

November 28, 2022

Primary Completion Date

March 19, 2024

Study Completion Date

August 8, 2024

Conditions
Atopic Dermatitis
Interventions
DRUG

Dupilumab

Dupilumab is administered as a subcutaneous (SC) injection.

DRUG

Upadacitinib

Extended-release tablet

Trial Locations (257)

100

National Taiwan University Hospital /ID# 249258, Taipei City

104

Mackay Memorial Hospital /ID# 249259, Taipei

116

Taipei Municipal Wan Fang Hospital /ID# 251500, Taipei

333

Linkou Chang Gung Memorial Hospital /ID# 249257, Taoyuan

833

Kaohsiung Chang Gung Memorial Hospital /ID# 249260, Kaohsiung City

1033

Clinexpert Kft /ID# 249822, Budapest

1085

Semmelweis Egyetem /ID# 251368, Budapest

1135

UNO Medical Trials /ID# 249820, Budapest

1200

Cliniques Universitaires UCL Saint-Luc /ID# 251403, Woluwe-Saint-Lambert

1407

Ambulatory for Specialized Medical Care for skin and venereal diseases /ID# 251272, Sofia

1431

Diagnostic Consultative Center Aleksandrovska /ID# 251137, Sofiya

1463

Diagnostic consultative center Focus-5 /ID# 251269, Sofia

1606

Medical Center Euroderma /ID# 251267, Sofia

Medical center EuroHealth /ID# 251270, Sofia

Military Medical Academy Multiprofile Hospital /ID# 251187, Sofia

2217

Premier Specialist /ID# 250572, Kogarah

2400

Bispebjerg and Frederiksberg Hospital /ID# 248902, Copenhagen NV

2900

Herlev and Gentofte Hospital /ID# 248900, Hellerup

3000

Universitair Ziekenhuis Leuven /ID# 251399, Leuven

3002

Sinclair Dermatology - Melbourne /ID# 249937, East Melbourne

3010

Inselspital, Universitaetsspital Bern /ID# 250577, Bern

3053

Skin Health Institute Inc /ID# 249938, Carlton

3200

Gyongyosi Bugat Pal Korhaz /ID# 251367, Gyöngyös

3630

Highway Medical Centre /ID# 250103, Durban

4000

CHU de Liege /ID# 251400, Liège

Roskilde Sygehus /ID# 248901, Roskilde

4001

DCC Pulmed AD /ID# 251271, Plovdiv

4031

DERMA-B Egeszsegugyi es Szolgaltato - Debrecen - Gyepusor Utca /ID# 249819, Debrecen

4032

Debreceni Egyetem-Klinikai Kozpont /ID# 249849, Debrecen

4102

Veracity Clinical Research /ID# 249943, Woolloongabba

5000

Allergo-Derm Bakos Kft. /ID# 249821, Szolnok

5800

UMHAT Dr Georgi Stranski EAD /ID# 251268, Pleven

6000

Grand Hopital de Charleroi /ID# 251401, Charleroi

MC Zara-Med EOOD /ID# 251135, Stara Zagora

Bacs-Kiskun Varmegyei Oktatokorhaz /ID# 249850, Kecskemét

6160

Fremantle Dermatology /ID# 249941, Fremantle

6720

Szegedi Tudományegyetem /ID# 249818, Szeged

7400

Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 249848, Kaposvár

7441

Spoke Research Inc /ID# 250091, CAPE TOWN Milnerton

7624

Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 250419, Pecs

7700

Allergy & Immunology (AIU) /ID# 249619, Cape Town

8200

Aarhus Universitetshospital - Skejby /ID# 248899, Aarhus

9007

Kantonsspital St. Gallen /ID# 250606, Sankt Gallen

10000

Poliklinika Solmed /ID# 252138, Grad Zagreb

DermaPlus - Poliklinika za dermatologiju i venerologiju /ID# 249591, Zagreb

Djecja bolnica Srebrnjak /ID# 249594, Zagreb

Klinicki bolnicki centar Zagreb /ID# 249596, Zagreb

Klinika za dječje bolesti Zagreb /ID# 249590, Zagreb

10467

Montefiore Medical Center - Moses Campus /ID# 251214, The Bronx

11217

Taipei Veterans General Hosp /ID# 249263, Taipei

11527

401 GSNA - 401 Army General Hospital /ID# 251843, Athens

13008

Hopital Saint Joseph /ID# 251053, Marseille

14584

Soon Chun Hyang University Hospital Bucheon /ID# 249812, Bucheon-si

15260

University of Pittsburgh MC /ID# 251208, Pittsburgh

15355

Korea University Ansan Hospital /ID# 249814, Ansan-si

15831

Dermatologische Gemeinschaftspraxis Mahlow /ID# 250306, Blankenfelde-Mahlow

16059

Uludag University Medical Faculty /ID# 249864, Bursa

16121

General Hospital Andreas Syggros /ID# 251842, Athens

16499

Ajou University Hospital /ID# 251491, Suwon

18014

Hospital Universitario Virgen de las Nieves /ID# 249785, Granada

20089

IRCCS Istituto Clinico Humanitas /ID# 251493, Rozzano

20122

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 250123, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf /ID# 249547, Hamburg

20354

Dermatologikum Hamburg /ID# 251390, Hamburg

21000

Klinicki Bolnicki Centar (KBC) Split /ID# 249879, Split

22903

University of Virginia - Dermatology /ID# 254166, Charlottesville

23502

Virginia Clinical Research, Inc. /ID# 249908, Norfolk

23538

Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 249560, Lübeck

23561

Taipei Medical University Shuang Ho Hospital /ID# 249256, New Taipei City

25123

ASST degli Spedali Civili di Brescia /ID# 250129, Brescia

27310

Gaziantep Universitesi /ID# 249868, Gaziantep

28046

Hospital Universitario La Paz /ID# 251518, Madrid

30059

National Taiwan University Hospital - Hsinchu branch /ID# 249265, Hsinchu

31400

CHU Toulouse - Hopital Larrey /ID# 251344, Toulouse

32256

Solutions Through Adv Rch /ID# 250455, Jacksonville

33016

Wellness Clinical Research - Miami Lakes /ID# 250236, Miami Lakes

33063

GSI Clinical Research, LLC /ID# 250768, Margate

33155

D&H National Research Centers /ID# 250734, Miami

33173

Florida International Rsrch cr /ID# 249667, Miami

33401

Metabolic Research Inst /ID# 250046, West Palm Beach

33428

Clearlyderm Dermatology /ID# 250457, Boca Raton

33607

Advanced Clinical Research Institute /ID# 250460, Tampa

33756

Olympian Clinical Research /ID# 250453, Clearwater

38039

Erciyes University Medical Faculty /ID# 249863, Kayseri

40705

Taichung Veterans General Hospital /ID# 249261, Taichung

41009

Hospital Universitario Virgen Macarena /ID# 249603, Seville

41124

Azienda Ospedaliero-Universitaria di Modena /ID# 250128, Modena

41944

Kyungpook National University Hospital /ID# 249855, Junggu

44000

CHU de Nantes, Hotel Dieu -HME /ID# 251347, Nantes

44106

Univ Hosp Cleveland /ID# 250699, Cleveland

44793

Hautarztpraxis Dr. Niesmann und Dr. Othlinghaus /ID# 251566, Bochum

46026

Hospital Universitario y Politecnico La Fe /ID# 251524, Valencia

46256

Dawes Fretzin, LLC /ID# 250276, Indianapolis

48013

Hospital Universitario Basurto /ID# 249784, Bilbao

48149

Universitaetsklinikum Muenster /ID# 249404, Münster

48346

Clarkston Dermatology /ID# 250225, Clarkston

48455

Fachklinik Bad Bentheim /ID# 249545, Bad Bentheim

49241

Pusan National University Hospital /ID# 249852, Busan

49565

Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 251392, Bramsche

50122

Ospedale Piero Palagi /ID# 250206, Florence

51000

Klinicki bolnicki centar Rijeka /ID# 249593, Rijeka

53127

Universitaetsklinikum Bonn /ID# 250307, Bonn

54055

Clinical Research Institute SC /ID# 249647, Tlalnepantla

55131

Universitaetsmedizin Mainz /ID# 249549, Mainz

55139

Ondokuz Mayis Universitesi /ID# 249865, Samsun

56126

Azienda Ospedaliero Universitaria Pisana /ID# 250124, Pisa

56429

Papageorgiou General Hospital /ID# 251840, Thessaloniki

57702

Health Concepts /ID# 250988, Rapid City

60590

Universitaetsklinikum Frankfurt /ID# 249544, Frankfurt am Main

64283

Klinikum Darmstadt /ID# 251391, Darmstadt

64506

MediSearch Clinical Trials /ID# 250272, Saint Joseph

64640

Centro de Dermatologia de Monterrey /ID# 249126, Monterrey

64718

Eukarya PharmaSite, SC /ID# 249702, Monterrey

66100

CAST - Center for Advanced Studies and Technology /ID# 251495, Chieti

67100

Presidio Ospedaliero San Salvatore /ID# 250127, L’Aquila

68516

Physician Research Collaboration, LLC /ID# 251099, Lincoln

69120

Universitaetsklinik Heidelberg /ID# 251458, Heidelberg

69495

HCL - Hopital Lyon Sud /ID# 251343, Pierre-Bénite

72076

Universitaetsklinikum Tuebingen /ID# 249552, Tübingen

72217

Arkansas Research Trials /ID# 250722, North Little Rock

72703

Clinical Trials Institute - Northwest Arkansas /ID# 249838, Fayetteville

75010

Hôpital Saint-Louis /ID# 251052, Paris

75231

Modern Research Associates, PLLC /ID# 250688, Dallas

76000

Hôpital Charles-Nicolle /ID# 251055, Rouen

76011

Arlington Research Center, Inc /ID# 250468, Arlington

77065

Center for Clinical Studies - Houston - Northwest Freeway /ID# 250039, Houston

77401

Bellaire Dermatology Associates /ID# 250739, Bellaire

79106

Universitaetsklinikum Freiburg /ID# 249555, Freiburg im Breisgau

81675

Klinikum rechts der Isar /ID# 249548, Munich

83706

Treasure Valley Medical Research /ID# 250727, Boise

84107

University of Utah /ID# 250042, Murray

85006

Medical Dermatology Specialists /ID# 250212, Phoenix

85032

Alliance Dermatology and Mohs Center /ID# 249671, Phoenix

88045

Derma Study Center Friedrichshafen GmbH /ID# 251460, Friedrichshafen

90045

Dermatology Research Associates /ID# 249829, Los Angeles

91120

Hadassah Medical Center-Hebrew University /ID# 251576, Jerusalem

91436

Joseph Raoof Md,Inc /Id# 250211, Encino

91910

Arké Estudios Clinicos Veracruz /ID# 250147, Veracruz

92708

First OC Dermatology /ID# 250686, Fountain Valley

93534

Antelope Valley Clinical Trials /ID# 249946, Lancaster

95817

University of California Davis Health /ID# 250044, Sacramento

97210

Oregon Dermatology and Research Center /ID# 250726, Portland

97223

Oregon Medical Research Center /ID# 249666, Portland

97239

Oregon Medical Research Center /ID# 250712, Portland

110001

The First Hospital of China Medical University /ID# 249638, Shenyang

200040

Huashan Hospital, Fudan University /ID# 250025, Shanghai

200443

Shanghai Skin Disease Hospital /ID# 249392, Shanghai

300052

Tianjin Medical University General Hospital /ID# 250246, Tianjin

310003

Hangzhou First People's Hospital /ID# 249437, Hangzhou

310009

The second affiliated hospital of Zhejiang University school of medicine /ID# 249655, Hangzhou

310014

Zhejiang Provincial People's Hospital /ID# 249653, Hangzhou

350005

The First Affiliated Hospital Of Fujian Medical University /ID# 249674, Fuzhou

400006

Private Practice - Dr. Orasan Remus /ID# 249625, Cluj-Napoca

410011

The Second Xiangya Hospital of Central South University /ID# 249657, Changsha

430022

Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 251485, Wuhan

510091

Dermatology Hospital of Southern Medical University /ID# 250121, Guangzhou

510180

Guangzhou First People's Hospital /ID# 249695, Guangzhou

510260

The Second Affiliated Hospital of Guangzhou Medical University /ID# 249694, Guangzhou

518048

The University of Hong Kong- Shenzhen Hospital /ID# 249436, Shenzhen

4941492

Rabin Medical Center /ID# 251578, Haifa

5938324

Dermatology and Ophthalmology Kume Clinic /ID# 254570, Sakai-shi

91320-2130

Clinical Trials Research Institute /ID# 250213, Thousand Oaks

80033-2896

Western States Clinical Res /ID# 250274, Wheat Ridge

06030

UConn Health /ID# 253807, Farmington

06519

Yale Center for Clinical Investigation /ID# 254791, New Haven

33486-2269

Skin Care Research Boca Raton /ID# 250458, Boca Raton

33021-6748

Skin Care Research - Hollywood /ID# 250459, Hollywood

33162-4708

Tory P Sullivan, MD PA /ID# 251136, North Miami Beach

33351-7311

Precision Clinical Research /ID# 250990, Sunrise

47906-1569

Randall Dermatology of West Lafayette /ID# 250234, West Lafayette

02215-5400

Beth Israel Deaconess Medical Center /ID# 251212, Boston

02169

Beacon Clinical Research, LLC /ID# 251412, Quincy

48202-3046

Henry Ford Medical Center - New Center One /ID# 250228, Detroit

63501-5362

Cleaver Dermatology /ID# 250725, Kirksville

68505-2343

Duplicate_Allergy, Asthma & Immunology Associates, PC /ID# 250616, Lincoln

43209-2422

Derm of Greater Columbus /ID# 250049, Bexley

45324-2640

Wright State Physicians - Fairborn /ID# 254167, Fairborn

74136-7049

Vital Prospects Clinical Research Institute, PC /ID# 249840, Tulsa

29425-8903

Duplicate_Medical University of South Carolina /ID# 251218, Charleston

37130-2450

International Clinical Research - Tennessee LLC /ID# 250724, Murfreesboro

78759-4100

Orion Clinical Research /ID# 250473, Austin

78218-3128

Texas Dermatology and Laser Specialists /ID# 250367, San Antonio

T2J 7E1

Dermatology Research Institute - Blackfoot Trail /ID# 251642, Calgary

T3A 2N1

Beacon Dermatology Inc /ID# 250336, Calgary

T6G 1C3

Alberta DermaSurgery Centre /ID# 250217, Edmonton

V3R 6A7

Dr. Chih-ho Hong Medical Inc. /ID# 251643, Surrey

V3V 0C6

Enverus Medical Research /ID# 251645, Surrey

R3M 3Z4

Wiseman Dermatology Research /ID# 250219, Winnipeg

E3B 1G9

Brunswick Dermatology Center /ID# 250220, Fredericton

L8L 3C3

LEADER Research /ID# 251647, Hamilton

N6H 5L5

DermEffects /ID# 250223, London

L3P 1X2

Lynde Institute for Dermatology /ID# 251854, Markham

L4Y 4C5

DermEdge Research Inc. /ID# 250216, Mississauga

K9J 5K2

SKiN Centre for Dermatology /ID# 251853, Peterborough

M3H 5Y8

Toronto Dermatology Centre /ID# 252098, Toronto

M4W 2N4

Research Toronto /ID# 250222, Toronto

N2J 1C4

Private Practice - Dr. Kim Papp Clinical Research /ID# 251644, Waterloo

G1V 4X7

Centre de Recherche dermatologique du Quebec Metropolitain /ID# 250427, Québec

04103

Universitaetsklinikum Leipzig /ID# 249562, Leipzig

01307

Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 251844, Dresden

00133

Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 250125, Rome

00144

IRCCS Istituti Fisioterapici Ospitalieri-Istituto Dermatologico San Gallicano /ID# 250558, Rome

00168

Policlinico Agostino Gemelli /ID# 251494, Rome

06156

Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 251572, Perugia

060-0063

Medical Corporation Kojinkai Sapporo Skin Clinic /ID# 252549, Sapporo

211-0063

Medical corporation Kojunkai Kosugi Dermatology Clinic /ID# 252554, Kawasaki-shi

252-0392

National Hospital Organization Sagamihara National Hospital /ID# 254518, Sagamihara-shi

220-6208

Queen's Square Medical Center, Dermatology and Allergology /ID# 252551, Yokohama

583-8588

Osaka Habikino Medical Center /ID# 252550, Habikino-shi

158-0097

Naoko Dermatology Clinic /ID# 254571, Setagaya-ku

06100

Cryptex Investigacion Clinica S.A de C.V /ID# 249994, Mexico City

4624 VT

Bravis Ziekenhuis /ID# 251395, Bergen op Zoom

1105 AZ

Amsterdam UMC, locatie AMC /ID# 251397, Amsterdam

60-529

Solumed Centrum Medyczne /ID# 249641, Poznan

87-100

MICS Centrum Medyczne Torun /ID# 251433, Torun

30-438

Lidia Rajzer - Specjalistyczny Gabinet Dermatologiczno-Kosmetyczny /ID# 252082, Krakow

31-011

Centrum Nowoczesnych Terapii Dobry Lekarz Sp. z o.o. /ID# 251437, Krakow

02-953

Klinika Ambroziak Sp. z o.o. /ID# 249406, Warsaw

02-962

Royalderm Agnieszka Nawrocka /ID# 251432, Warsaw

03-712

Bodyclinic Sp. z o.o. sp.k. /ID# 249599, Warsaw

38-440

Zespol Naukowo-Leczniczy Iwolang Dermatologiczne Centrum Uzdrowiskowe Sp. z o.o /ID# 249598, Iwonicz-Zdrój

15-077

INTER CLINIC Piotr Adrian Klimiuk /ID# 251430, Bialystok

80-546

Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 251431, Gdansk

82-300

Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 251438, Elblag

30-033

Centrum Medyczne ALL-MED Badania Kliniczne /ID# 249630, Krakow

90-265

Dermed Centrum Medyczne Sp. z o.o /ID# 251429, Lodz

4839-008

Centro Hospitalar Do Alto Ave - Hospital Senhora Da Oliveira /ID# 249196, Guimarães

1998-018

Hospital CUF Descobertas /ID# 249193, Lisboa

4099-001

Centro Hospitalar Universitario do Porto, EPE - Hospital Santo Antonio /ID# 249191, Porto

2805-267

Hospital Garcia de Orta /ID# 251455, Almada

4710-243

2CA-Braga, Hospital de Braga /ID# 250480, Braga

2410-197

Unidade Local de Saude da Regiao de Leiria, EPE /ID# 249194, Leiria

1169-050

Centro Hospitalar de Lisboa Central /ID# 249195, Lisbon

4464-513

Unidade Local de Saúde de Matosinhos, EPE /ID# 249197, Matosinhos Municipality

4200-319

Centro Hospitalar Universitario de Sao Joao, EPE /ID# 249192, Porto

00727

Dr. Samuel Sanchez PSC /ID# 250389, Caguas

00985

Alma M. Cruz Santana, MD-Private practice /ID# 250393, Carolina

00909-1711

Clinical Research Puerto Rico /ID# 250394, San Juan

00917-3104

GCM Medical Group PSC /ID# 250391, San Juan

010701

Bio Terra Med SRL /ID# 249624, Bucharest

851 01

Derma therapy spol /ID# 249783, Bratislava

811 09

Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 249746, Bratislava

841 04

BeneDerma s.r.o. /ID# 251791, Bratislava

0001

University of Pretoria /ID# 250208, Pretoria

0181

About Allergy /ID# 249697, Pretoria

06973

Chungang University Hospital /ID# 251490, Dongjak-gu

03080

Seoul National University Hospital /ID# 251492, Seoul

05030

Konkuk University Medical Center /ID# 249811, Seoul

08916

Hospital Universitario Germans Trias i Pujol /ID# 251523, Badalona

08950

Hospital Sant Joan de Deu /ID# 249602, Esplugues de Llobregat

03010

Hospital General Universitario de Alicante Doctor Balmis /ID# 251517, Alicante

214 28

Skane University hospital /ID# 250332, Malmo

171 64

Karolinska University Hospital Solna /ID# 250328, Solna

581 85

Norrlands University hospital /ID# 250329, Umeå

633 49

Malarsjukhuset /ID# 251908, Eskilstuna

06800

Ankara City Hospital /ID# 249870, Ankara

07059

Akdeniz Universitesi Tip Fakul /ID# 249866, Antalya

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