A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

January 25, 2023

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Severe Aplastic Anemia
Interventions
DRUG

cyclosporine

cyclosporine

PROCEDURE

Matched Unrelated Donor Hematopoetic Stem Cell Transplant

Matched Unrelated Donor (MUD) Hematopoietic Stem Cell Transplantation (HSCT)

DRUG

horse anti-thymocyte globulin (ATG)

horse anti-thymocyte globulin (ATG)

DRUG

rabbit anti-thymocyte globulin (ATG)

rabbit anti-thymocyte globulin (ATG)

DRUG

Methotrexate

methotrexate

DRUG

Fludarabine

fludarabine

DRUG

Cyclophosphamide

cyclophosphamide

RADIATION

low-dose total body irradiation (TBI)

low-dose total body irradiation (TBI)

PROCEDURE

Immunosuppressive Therapy (IST)

Immunosuppressive Therapy (IST)

Trial Locations (52)

10032

Columbia University Medical Center, New York

11040

Cohen Children's Medical Center of New York, New Hyde Park

14263

Roswell Park Comprehensive Cancer Center, Buffalo

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Nemours Children's Hospital, Delaware, Wilmington

20010

Children's National Hospital, Washington D.C.

23507

Children's Hospital of the King's Daughter, Norfolk

27599

University of North Carolina, Chapel Hill

27705

Duke University, Durham

28203

Levine Children's Hospital, Charlotte

30322

Children's Hospital of Atlanta/Emory, Atlanta

32610

University of Florida, Gainesville

33136

University of Miami, Miami

33155

Nicklaus Children's Hospital, Miami

33701

Johns Hopkins All Children's Hospital, St. Petersburg

35249

University of Alabama at Birmingham, Birmingham

37203

Vanderbilt University Medical Center, Nashville

38105

St. Jude Children's Research Hospital, Memphis

39216

University of Mississippi Medical Center, Jackson

43205

Nationwide Children's Hospital, Columbus

46202

Indiana University Hospital/Riley Hospital for Children, Indianapolis

48109

University of Michigan, Ann Arbor

49503

Helen DeVos Children's Hospital, Grand Rapids

53792

University of Wisconsin, Madison

55902

Mayo Clinic Rochestser, Rochester

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

60637

University of Chicago, Chicago

63110

Washington University in St. Louis, St Louis

70118

Children's Hospital NOLA, New Orleans

72202

Arkansas, Little Rock

75235

Children's Medical Center Dallas, Dallas

77030

Texas Children's Hospital, Houston

78229

Methodist Healthcare, San Antonio

80045

Children's Hospital Colorado, Aurora

84112

University of Utah/Primary Children's Hospital, Salt Lake City

85016

Phoenix Children's Hospital, Phoenix

90027

Children's Hospital Los Angeles, Los Angeles

90095

UCLA, Los Angeles

92123

Rady Children's Hospital San Diego, San Diego

92354

Loma Linda, Loma Linda

92868

Children's Hospital of Orange County, Orange

94158

University of California San Francisco, San Francisco

94304

Stanford, Palo Alto

94609

Children's Hospital & Research Center Oakland, Oakland

97239

Oregon Health & Science University, Portland

98109

Fred Hutchinson Cancer Center, Seattle

06520

Yale University, New Haven

04074

Maine Health, Scarborough

02115

Boston Children's Hospital, Boston

07601

Hackensack University Medical Center, Hackensack

V6H 3V4

British Columbia Children's, Vancouver

R3E 0V9

Winnipeg CancerCare Manitoba, Winnipeg

All Listed Sponsors
collaborator

Center for International Blood and Marrow Transplant Research

NETWORK

collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

North American Pediatric Aplastic Anemia Consortium

UNKNOWN

collaborator

Pediatric Transplantation and Cellular Therapy Consortium

OTHER

collaborator

Blood and Marrow Transplant Clinical Trials Network

NETWORK

lead

Boston Children's Hospital

OTHER