Combined Effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on Breathing

PHASE4CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

October 10, 2022

Primary Completion Date

January 12, 2024

Study Completion Date

January 12, 2024

Conditions

Opioid-induced Respiratory Depression

Interventions

DRUG

Pregabalin 150mg

one capsule of 150mg 90 minutes after 10mg of oxycodone

DRUG

Oxycodone 10mg

one 10mg tablet

DRUG

Lacosamide 150 mg

one capsule of 150mg 90 minutes after 10mg of oxycodone

Trial Locations (1)

Leiden University Medical Center, Leiden

All Listed Sponsors

lead

Leiden University Medical Center

OTHER