Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)

RecruitingOBSERVATIONAL
Enrollment

210

Participants

Timeline

Start Date

September 28, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2026

Conditions
Lung Cancer, Non-small CellEGFR Gene MutationEGFR-TKI Resistant MutationPrimary ResistanceCirculating Tumor DNA
Interventions
OTHER

Genomic profiles detection

The Paraffin-embedded tumor tissue at diagnosis is collected and assessed by Next- generation gene sequencing

OTHER

circulating tumor DNA detection

The Plasma at diagnosis and at 1-month treatment are collected and assessed by Next-generation gene sequencing

Trial Locations (1)

410011

RECRUITING

Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha

All Listed Sponsors
collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

Shanghai Chest Hospital

OTHER

collaborator

West China Hospital

OTHER

collaborator

Hunan Cancer Hospital

OTHER

collaborator

The Third Xiangya Hospital of Central South University

OTHER

collaborator

The First Affiliated Hospital of Xiamen University

OTHER

collaborator

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER

collaborator

China-Japan Friendship Hospital

OTHER

collaborator

Fudan University

OTHER

collaborator

First Affiliated Hospital of Kunming Medical University

OTHER

collaborator

Loudi Central Hospital

OTHER

collaborator

ZhuZhou Central Hospital

OTHER

collaborator

Xiangtan Central Hospital

OTHER

collaborator

First People's Hospital of Chenzhou

OTHER

collaborator

Yueyang Central Hospital

OTHER

collaborator

Yongzhou Central Hospital

UNKNOWN

collaborator

The First Affiliated Hospital of University of South China

OTHER

collaborator

Hunan Provincial People's Hospital

OTHER

collaborator

Shaoyang Central Hospital

UNKNOWN

collaborator

Yiyang Central Hospital

UNKNOWN

collaborator

Changsha Central Hospital

OTHER

collaborator

The first people's hospital of Guiyang

UNKNOWN

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

Renmin Hospital of Wuhan University

OTHER

collaborator

The First People's Hospital of Changde City

OTHER

collaborator

Zhuzhou Second Hospital

UNKNOWN

collaborator

First Hospital of Changsha

UNKNOWN

collaborator

Hengyang Central Hospital

OTHER_GOV

collaborator

Huaihua first people's Hospital

UNKNOWN

collaborator

The First People's Hospital of Xiangtan

UNKNOWN

collaborator

University of South China Affiliated Nanhua Hospital

UNKNOWN

collaborator

Xiangxi Autonomous Prefecture People's Hospital

UNKNOWN

collaborator

People's Hospital of Zhangjiajie

UNKNOWN

collaborator

Second People's Hospital Of Huaihua

UNKNOWN

collaborator

Hunan Academy of Traditional Chinese Medicine Affiliated Hospital

UNKNOWN

collaborator

The Third Hospital of Changsha

UNKNOWN

collaborator

Xiangya Changde Hospital

UNKNOWN

collaborator

Changsha County first People's Hospital

UNKNOWN

collaborator

Hunan Provincial Straight Hospital of Traditional Chinese Medicine

UNKNOWN

collaborator

Liuyang Hospital of traditional Chinese Medicine

UNKNOWN

collaborator

Second People's Hospital of Hunan

OTHER

collaborator

First Affiliated Hospital of Guangxi Medical University

OTHER

collaborator

Guiyang Public Health Treatment Center

UNKNOWN

collaborator

The Affiliated Bethune Hospital of Shanxi Medical University

UNKNOWN

collaborator

Hunan University of Traditional Chinese Medicine

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

The First Affiliated Hospital of Nanchang University

OTHER

lead

Second Xiangya Hospital of Central South University

OTHER