NCT05595603View on ClinicalTrials.gov

Zoledronic Acid-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Bone Tumor After Intralesional Curettage

PHASE2RecruitingINTERVENTIONAL
Enrollment

153

Participants

Timeline

Start Date

March 31, 2023

Primary Completion Date

June 1, 2026

Study Completion Date

December 1, 2026

Conditions
Giant Cell Tumor of Bone
Interventions
PROCEDURE

4mg ZOL loaded gentamicin PMMA

During surgery, 4mg ZOL will be mixed with gentamicin (1000mg) PMMA cement (40g) by surgeon under sterile conditions to prepare ZOL loaded bone cement, and then it will be filled into the bony defects of the patient where the lesion has been removed after intralesional curettage.

PROCEDURE

gentamicin PMMA

During surgery, gentamicin (1000mg) PMMA (40g) was prepared by surgeon under sterile conditions and will be filled into the bony defects of the patient where the lesion has been removed after intralesional curettage.

Trial Locations (1)

311200

RECRUITING

The Second Affiliated Hospital of Zhejiang University, Hangzhou

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER