NCT05583721View on ClinicalTrials.gov

Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

October 10, 2023

Primary Completion Date

September 30, 2027

Study Completion Date

September 30, 2028

Conditions
Sickle Cell Disease
Interventions
DRUG

[13N]NH3

Ammonia N 13 (a radioactive tracer) will be given per intravenous (IV) injection for diagnostic purposes in conjunction with positron emission tomography (PET) imaging.

DRUG

Lexiscan

Given IV prior to PET stress test

DIAGNOSTIC_TEST

Positron emission tomography

Participants will complete a onetime PET (stress-rest) myocardial perfusion scan.

Trial Locations (1)

38105

RECRUITING

St. Jude Children's Research Hospital, Memphis

All Listed Sponsors
lead

St. Jude Children's Research Hospital

OTHER