PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers

PHASE4RecruitingINTERVENTIONAL
Enrollment

594

Participants

Timeline

Start Date

May 18, 2023

Primary Completion Date

January 3, 2026

Study Completion Date

January 3, 2026

Conditions
Upper GI BleedingProton Pump Inhibitors
Interventions
DRUG

Vonoprazan

Vonoprazan 40 mg bid orally for 72 hours, and from day 4-30 VPZ 20 mg daily

DRUG

esomeprazole

A high dose PPI infusion (esomeprazole 80mg iv bolus followed by 8mg per hour for 72 hours), and frorm day 4-30 oral esomeprazole daily

Trial Locations (8)

Unknown

RECRUITING

Nanfang Hospital Southern Medical University, Guangzhou

NOT_YET_RECRUITING

The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou

NOT_YET_RECRUITING

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou

NOT_YET_RECRUITING

Shenzhen Pingshan District People's Hospital, Shenzhen

NOT_YET_RECRUITING

The Second Affiliated Hospital The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen

NOT_YET_RECRUITING

Yangjiang People's Hospital of Guangdong Medical University, Yangjiang

NOT_YET_RECRUITING

Zhuhai People's Hospital (Zhuhai Hospital Affiliated to Jinan University), Zhuhai

NOT_YET_RECRUITING

Prince of Wales Hospital, Hong Kong

All Listed Sponsors
collaborator

Nanfang Hospital, Southern Medical University

OTHER

lead

Chinese University of Hong Kong

OTHER