NCT05582044View on ClinicalTrials.gov

Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

January 25, 2023

Primary Completion Date

January 31, 2026

Study Completion Date

January 31, 2026

Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
OTHER

Lower-body Negative Pressure (-25 mmHg)

The LBNP chamber will be sealed at the waist prior to Control measures, and the vacuum system will be activated to coincide with the onset of exercise, applying -25mmHg LBNP.

OTHER

Lower-body Negative Pressure (-15 mmHg)

The LBNP chamber will be sealed at the waist prior to Control measures, and the vacuum system will be activated to coincide with the onset of exercise, applying -15mmHg LBNP.

OTHER

Lower-body Neutral Pressure (0 mmHg)

In this placebo trial, the LBNP chamber will be sealed at the waist prior to Control measures, and the vacuum system will be activated to coincide with the onset of exercise, but the chamber will be vented to atmosphere.

Trial Locations (1)

V1V1V7

RECRUITING

University of British Columbia, Kelowna

All Listed Sponsors
lead

University of British Columbia

OTHER