Comparison of Low-Intensity Statin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus (PROVE-DM)

PHASE4RecruitingINTERVENTIONAL
Enrollment

4,000

Participants

Timeline

Start Date

March 14, 2023

Primary Completion Date

December 31, 2030

Study Completion Date

December 31, 2030

Conditions
Pre DiabetesASCVD
Interventions
DRUG

high-intensity statin arm

•high-intensity statin strategy (standard arm): rosuvastatin 20 mg PO qd, once daily

DRUG

low-intensity statin plus ezetimibe

•low-intensity statin plus ezetimibe strategy (experimental arm): rosuvastatin 5mg /ezetimibe 10mg PO qd), once daily

Trial Locations (30)

Unknown

ENROLLING_BY_INVITATION

Bycheon Sejong Hospital, Bucheon-si

ENROLLING_BY_INVITATION

Gyeongsang National University Changwon Hospital, Changwon

ENROLLING_BY_INVITATION

Chungbuk National University Hospital, Cheonju

ENROLLING_BY_INVITATION

Gangwon National University Hospital, Chuncheon

ENROLLING_BY_INVITATION

Daegu Catholic University Medical Center, Daegu

ENROLLING_BY_INVITATION

Keimyung University Dongsan Medical Center, Daegu

NOT_YET_RECRUITING

Yungnam universury Hospital, Daegu

ENROLLING_BY_INVITATION

Chungnam National University Sejong Hospital, Daejeon

ENROLLING_BY_INVITATION

Konyang University Hospital, Daejeon

NOT_YET_RECRUITING

the Catholic University of Korea, Daejeon St. Mary'S Hospital, Daejeon

ENROLLING_BY_INVITATION

Gangneung Asan Hospital, Gangneung

NOT_YET_RECRUITING

Chonnam National University Hospital, Gwangju

NOT_YET_RECRUITING

Inje University Haeundae Paik Hospital, Haeundae

NOT_YET_RECRUITING

Hallym University Medical Center, Hwaseong-si

NOT_YET_RECRUITING

Gachon University Gil Medical Center, Incheon

NOT_YET_RECRUITING

Jeju National University Hospital, Jeju City

ENROLLING_BY_INVITATION

Gyeongsang National University Hospital, Jinju

RECRUITING

Chungnam National University Hospital, Jungnam

ENROLLING_BY_INVITATION

Dong-A Medical Center, Pusan

ENROLLING_BY_INVITATION

Inje University Busan Paik Hospital, Pusan

ENROLLING_BY_INVITATION

Kosin University Gospel Hospital, Pusan

NOT_YET_RECRUITING

Pusan National University Yangsan Hospital, Pusan

ENROLLING_BY_INVITATION

Asan Medical Center, Seoul

ENROLLING_BY_INVITATION

Ewha womans university seoul hospital, Seoul

NOT_YET_RECRUITING

Kangdong Sacred Heart Hospital, Seoul

ENROLLING_BY_INVITATION

Korea University Anam Hospital, Seoul

ENROLLING_BY_INVITATION

The Catholic Univ. of Korea Eunpyeong St. Mary's hospital, Seoul

NOT_YET_RECRUITING

VHS Medical Center, Seoul

ENROLLING_BY_INVITATION

The Catholic University of Korea, St. Vincent's Hospital, Suwon

NOT_YET_RECRUITING

Ulsan university hospital, Ulsan

All Listed Sponsors
collaborator

Yuhan Corporation

INDUSTRY

lead

Seung-Whan Lee, M.D., Ph.D.

OTHER