NCT05579366 - Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001) | Biotech Hunter

Enrollment

569

Participants

Timeline

Start Date

December 7, 2022

Primary Completion Date

June 30, 2027

Study Completion Date

September 30, 2027

Conditions

High Grade Epithelial Ovarian CancerHigh Grade Serous Ovarian CancerPrimary Peritoneal CarcinomaFallopian Tube CancerEndometrial CancerNon-small Cell Lung CancerEpidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer (NSCLC)MesotheliomaBreast AdenocarcinomaTriple Negative Breast CancerHormone Receptor-positive/Her2 Negative Breast CancerPlatinum-resistant Ovarian Cancer (PROC)Platinum Sensitive Ovarian Cancer (PSOC)Primary Refractory Ovarian CancerUterine Cancer

Interventions

DRUG

Rina-S

Intravenous infusion of Rina-S

DRUG

Carboplatin

Carboplatin intravenous infusion

DRUG

Bevacizumab

Bevacizumab intravenous infusion

DRUG

Pembrolizumab

Pembrolizumab intravenous infusion

Trial Locations (38)

18901

RECRUITING

USOR Alliance Cancer Specialist, Doylestown

20850

RECRUITING

USOR Maryland Oncology Hematology, Rockville

22031

RECRUITING

USOR Virginia Cancer Specialists, Fairfax

23502

RECRUITING

USOR Virginia Oncology Associates, Norfolk

33401

RECRUITING

USOR Florida Cancer Specialists East, West Palm Beach

33709

RECRUITING

USOR Florida Cancer Specialists North, St. Petersburg

33908

RECRUITING

USOR Florida Cancer Specialists South, Fort Myers

37203

RECRUITING

Sarah Cannon Research Institute at Tennessee Oncology, Nashville

48085

RECRUITING

Karmanos Cancer Institute, Detroit

49503

RECRUITING

START Midwest, Grand Rapids

55109

RECRUITING

USOR Minnesota Oncology Hematology, Maplewood

66205

RECRUITING

University of Kansas Medical Center (KUMC), Westwood

73104

RECRUITING

University of Oklahoma - Health Sciences Center, Oklahoma City

75521

RECRUITING

Mary Crowley Cancer Research, Dallas

75702

RECRUITING

Texas Oncology - Northeast TX, Tyler

76104

RECRUITING

USOR Texas Oncology, Fort Worth

77380

RECRUITING

USOR Texas Oncology Gulf Coast, Woodland

78758

RECRUITING

Texas Oncology - Central / South Texas, Austin

79606

RECRUITING

USOR Texas Oncology, Abilene

84119

RECRUITING

START Mountain Region, West Valley City

85016

RECRUITING

USOR HonorHealth, Phoenix

85711

RECRUITING

USOR Arizona Oncology Associates, Tucson

90095

RECRUITING

University of California Los Angeles Medical Center, Los Angeles

92093

RECRUITING

University of California, San Diego; Moores Cancer Center, San Diego

93105

RECRUITING

USOR Sansum Clinic, Santa Barbara

95403

RECRUITING

Providence Medical Foundation, Santa Rosa

97227

RECRUITING

Compass Oncology - Rose Quarter, Portland

97401

RECRUITING

USOR Oncology Associates of Oregon, P.C., Eugene

98104

RECRUITING

Swedish Cancer Institute, Seattle

02114

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Dana Farber Cancer Institute, Boston

02905

RECRUITING

Women and Infants Hospital of Rhode Island, Providence

Unknown

RECRUITING

Cancer hospital, Chinese Academy of Medical Sciences, Beijing

RECRUITING

Hunan Cancer Hospital - Phase 1, Changsha

RECRUITING

Hunan Cancer Hospital - Thoracic Medicine Dept II, Changsha

RECRUITING

Jilin Cancer Hospital, Changchun

RECRUITING

Fudan University Shanghai Cancer Center - Gynecologic Oncology, Shanghai

RECRUITING

Fudan University Shanghai Cancer Center- Phase 1, Shanghai