SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

February 6, 2023

Primary Completion Date

October 31, 2025

Study Completion Date

December 31, 2026

Conditions
Rectal CancerLocally Advanced
Interventions
RADIATION

Short-course radiotherapy

5×5Gy in Week 1

DRUG

Penpulimab

Apply once in the first week, then every 3 weeks from the third week for four cycles

DRUG

CAPEOX

Apply every 3 weeks from week 3 for 4 cycles

PROCEDURE

TME surgery

Patient will receive radical rectal cancer surgery

Trial Locations (1)

200025

RECRUITING

Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

All Listed Sponsors
lead

Ruijin Hospital

OTHER

collaborator

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

INDUSTRY