Formatting the Risk Prediction Models for Never-Smoking Lung Cancer

RecruitingOBSERVATIONAL
Enrollment

10,000

Participants

Timeline

Start Date

December 15, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2029

Conditions
Lung Cancer
Interventions
OTHER

LDCT lung cancer screen, immediately

"Participants will receive the following things in sequence~1. Non-smoker lung cancer prediction model among Taiwanese population by questionnaire~2. Check autoantibodies against p53, NY-ESO-1, CAGE, GBU4-5, HuD, MAGE A4 and SOX2 in the blood of recruited patients and detect 133 SNPs and 11 mitochondrial mutations which are highly correlated with never-smoking lung cancer in our preliminary data~3. Check total bilirubin, urinary heavy metals, serum tumor marker, including CEA, alpha-fetal protein, etc.~4. Check pulmonary function test and chest X ray~5. Arrenge chest CT right away, and detection, classification, prediction of lung cancer risk in CT using deep learning and radiomics~6. Optimization and validation of lung cancer risk and probability prediction model: prospective multicenter clinical study."

OTHER

LDCT lung cancer screen, later

"Participants will receive the following things in sequence~1. Non-smoker lung cancer prediction model among Taiwanese population by questionnaire~2. Check autoantibodies against p53, NY-ESO-1, CAGE, GBU4-5, HuD, MAGE A4 and SOX2 in the blood of recruited patients and detect 133 SNPs and 11 mitochondrial mutations which are highly correlated with never-smoking lung cancer in our preliminary data~3. Check total bilirubin, urinary heavy metals, serum tumor marker, including CEA, alpha-fetal protein, etc.~4. Check pulmonary function test.~5. Arrange AI-asisted chest X-ray right away.~6. Arrange chest CT three years later, and detection, classification, prediction of lung cancer risk in CT using deep learning and radiomics~7. Optimization and validation of lung cancer risk and probability prediction model: prospective multicenter clinical study."

Trial Locations (7)

402

RECRUITING

Chung Shan Medical University Hospital, Taichung

100229

RECRUITING

National Taiwan University Hospital, Taipei

Unknown

RECRUITING

National Taiwan University Hospital Hsin-Chu Branch, Hsinchu

RECRUITING

Hualien Tzu Chi Hospital, Hualien City

NOT_YET_RECRUITING

E-Da Hospital, Kaohsiung City

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

NOT_YET_RECRUITING

Ministry of Health and Welfare Shuang-Ho Hospital, New Taipei City

All Listed Sponsors
collaborator

Ministry of Health and Welfare, Taiwan

OTHER_GOV

lead

Chung Shan Medical University

OTHER