A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma

PHASE3RecruitingINTERVENTIONAL
Enrollment

650

Participants

Timeline

Start Date

March 29, 2023

Primary Completion Date

February 13, 2026

Study Completion Date

August 31, 2031

Conditions
Relapsed or Refractory Multiple Myeloma
Interventions
DRUG

Teclistamab

Teclistamab will be administered subcutaneously.

DRUG

Pomalidomide

Pomalidomide will be administered orally.

DRUG

Bortezomib

Bortezomib will be administered subcutaneously.

DRUG

Dexamethasone

Dexamethasone will be administered orally in PVd and intravenously or orally in Kd.

DRUG

Carfilzomib

Carfilzomib will be administered intravenously.

Trial Locations (210)

2148

ACTIVE_NOT_RECRUITING

Blacktown Hospital, Blacktown

2930

ACTIVE_NOT_RECRUITING

Algemeen Ziekenhuis Klina, Brasschaat

3000

ACTIVE_NOT_RECRUITING

Universitair Ziekenhuis Gasthuisberg, Leuven

3065

ACTIVE_NOT_RECRUITING

St Vincents Hospital Melbourne, Fitzroy

3128

ACTIVE_NOT_RECRUITING

Box Hill Hospital, Melbourne

4000

ACTIVE_NOT_RECRUITING

CHR de la Citadelle, Liège

5000

COMPLETED

Odense Universitetshospital, Odense C

5020

ACTIVE_NOT_RECRUITING

LKH - Universitätsklinikum der PMU Salzburg, Salzburg

6009

ACTIVE_NOT_RECRUITING

Sir Charles Gairdner Hospital, Nedlands

6150

ACTIVE_NOT_RECRUITING

Fiona Stanley Hospital, Murdoch

7100

ACTIVE_NOT_RECRUITING

Jolimont, Haine-St-Paul

ACTIVE_NOT_RECRUITING

Vejle Sygehus, Vejle

7400

ACTIVE_NOT_RECRUITING

Regionshospitalet Godstrup, Herning

8200

ACTIVE_NOT_RECRUITING

Aarhus University Hospital, Aarhus

8500

ACTIVE_NOT_RECRUITING

Az Groeninge, Kortrijk

9000

ACTIVE_NOT_RECRUITING

Aalborg University Hospital, Aalborg

10032

RECRUITING

Herbert Irving Comprehensive Cancer Center Columbia University Medical Center, New York

10126

ACTIVE_NOT_RECRUITING

A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette, Turin

10450

ACTIVE_NOT_RECRUITING

Hospital Pulau Pinang, George Town

11407

ACTIVE_NOT_RECRUITING

Hosp. de Jerez de La Frontera, Jerez de la Frontera

14003

ACTIVE_NOT_RECRUITING

Hôpital Côte de Nacre, Caen

17475

ACTIVE_NOT_RECRUITING

Universitätsmedizin Greifswald, Greifswald

17601

COMPLETED

Penn Medicine Lancaster General Health, Lancaster

20070

COMPLETED

Pamukkale University Medical Faculty, Denizli

20133

ACTIVE_NOT_RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20889

COMPLETED

Walter Reed National Military Medical Center, Bethesda

20904

RECRUITING

Maryland Oncology Hematology P A, Silver Spring

21100

ACTIVE_NOT_RECRUITING

Ospedale di Circolo e Fondazione Macchi, Varese

22060

COMPLETED

Alexander T. Augusta Military Medical Center, Fort Belvoir

22763

ACTIVE_NOT_RECRUITING

Asklepios Klinik Altona, Hamburg

23502

ACTIVE_NOT_RECRUITING

Virginia Oncology Associates, Norfolk

24008

ACTIVE_NOT_RECRUITING

Hosp. de Leon, León

25287

ACTIVE_NOT_RECRUITING

Helsingborgs lasarett, Helsingborg

27705

ACTIVE_NOT_RECRUITING

Durham VAMC, Durham

28031

ACTIVE_NOT_RECRUITING

Hosp. Univ. Infanta Leonor, Madrid

28034

ACTIVE_NOT_RECRUITING

Hosp. Univ. Ramon Y Cajal, Madrid

28041

ACTIVE_NOT_RECRUITING

Hosp. Univ. 12 de Octubre, Madrid

28223

ACTIVE_NOT_RECRUITING

Hosp. Quiron Madrid Pozuelo, Pozuelo de Alarcón

30008

ACTIVE_NOT_RECRUITING

Hosp. Gral. Univ. J.M. Morales Meseguer, Murcia

31048

ACTIVE_NOT_RECRUITING

Bnai Zion Medical Center, Haifa

31100

ACTIVE_NOT_RECRUITING

Institut Universitaire du Cancer Toulouse Oncopole, Toulouse

32806

COMPLETED

Orlando Health Cancer Institute, Orlando

33011

COMPLETED

Hospital Universitario Central de Asturias, Oviedo

33100

ACTIVE_NOT_RECRUITING

ASUI Santa Maria della Misericordia di Udine, Udine

33136

RECRUITING

University of Miami Sylvester Cancer Center, Miami

33331

RECRUITING

Cleveland Clinic Florida, Weston

34090

ACTIVE_NOT_RECRUITING

CHU de Montpellier Hopital Saint Eloi, Montpellier

34214

ACTIVE_NOT_RECRUITING

Medipol University Hospital, Istanbul

35043

COMPLETED

Universitaetsklinikum Giessen und Marburg GmbH, Marburg

36071

COMPLETED

Hosp. Montecelo, Pontevedra

37203

COMPLETED

Tennessee Oncology, Nashville

38700

ACTIVE_NOT_RECRUITING

CHU Grenoble, Grenoble

40138

ACTIVE_NOT_RECRUITING

A O U Sant Orsola Malpighi, Bologna

42123

ACTIVE_NOT_RECRUITING

Arcispedale Santa Maria Nuova - IRCCS, Reggio Emilia

44000

ACTIVE_NOT_RECRUITING

CHU Nantes, Nantes

46026

ACTIVE_NOT_RECRUITING

Hospital Universitari i Politecnic La Fe, Valencia

47500

COMPLETED

Subang Jaya Medical Centre, Subang Jaya

49100

ACTIVE_NOT_RECRUITING

Rabin Medical Center, Petah Tikva

50263

RECRUITING

Mission Cancer Blood, Waukee

52621

ACTIVE_NOT_RECRUITING

Sheba Medical Center, Ramat Gan

53100

ACTIVE_NOT_RECRUITING

A O Universitaria Senese Ospedale Santa Maria alle Scotte, Siena

54500

ACTIVE_NOT_RECRUITING

CHU de Nancy - Hopital de Brabois, Vandœuvre-lès-Nancy

55280

ACTIVE_NOT_RECRUITING

Ondokuz Mayis University, Atakum

56126

ACTIVE_NOT_RECRUITING

Ospedale Santa Chiara AO Universitaria Pisana, Pisa

59020

ACTIVE_NOT_RECRUITING

Hopital Saint Vincent de Paul, Lille

59100

COMPLETED

University Malaya Medical Centre, Kuala Lumpur

63017

COMPLETED

Saint Lukes Hospital Saint Lukes Cancer Specialists, Chesterfield

64239

ACTIVE_NOT_RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

69120

COMPLETED

Universitaetsklinikum Heidelberg, Heidelberg

70006

COMPLETED

East Jefferson General Hospital Bone Marrow Transport Clinic, Metairie

72000

ACTIVE_NOT_RECRUITING

Centre Hospitalier du Mans, Le Mans

72076

COMPLETED

Universitatsklinikum Tubingen, Tübingen

75012

ACTIVE_NOT_RECRUITING

Hopital Saint-Antoine, Paris

75013

ACTIVE_NOT_RECRUITING

Hopital de la Pitie Salpetriere, Paris

75743

ACTIVE_NOT_RECRUITING

Hopital Necker Enfants Malades, Paris

77030

COMPLETED

Baylor College of Medicine, Houston

ACTIVE_NOT_RECRUITING

Michael E DeBakey VA Medical Center, Houston

77054

COMPLETED

Harris Health Smith Clinic, Houston

78234

RECRUITING

Brooke Army Medical Center, Fort Sam Houston

80000

ACTIVE_NOT_RECRUITING

CHU Amiens - Hopital Sud, Amiens

80218

ACTIVE_NOT_RECRUITING

Rocky Mountain Cancer Centers, Aurora

84106

RECRUITING

Utah Cancer Specialists, Salt Lake City

85234

ACTIVE_NOT_RECRUITING

Banner MD Anderson Cancer Center, Gilbert

88200

ACTIVE_NOT_RECRUITING

Hospital Queen Elizabeth, Kota Kinabalu

89070

ACTIVE_NOT_RECRUITING

Universitatsklinikum Ulm, Ulm

90127

ACTIVE_NOT_RECRUITING

Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo

90602

COMPLETED

PIH Health Hospital, Whittier

90806

ACTIVE_NOT_RECRUITING

MemorialCare Long Beach Medical Center, Long Beach

92868

ACTIVE_NOT_RECRUITING

University of California Irvine, Orange

94704

COMPLETED

Alta Bates Comprehensive Cancer Center, Berkeley

98405

ACTIVE_NOT_RECRUITING

NorthWest Medical Specialties, PLLC, Tacoma

99508

COMPLETED

Alaska Oncology and Hematology LLC, Anchorage

100020

ACTIVE_NOT_RECRUITING

Beijing Chaoyang Hospital, Beijing

102208

ACTIVE_NOT_RECRUITING

BeiJing JiShuiTan Hospital, Beijing

110055

ACTIVE_NOT_RECRUITING

Shengjing Hospital Of China Medical University, Shenyang

122002

ACTIVE_NOT_RECRUITING

Fortis Memorial Research Institute, Gūrgaon

130021

ACTIVE_NOT_RECRUITING

The First Bethune Hospital of Jilin University, Changchun

150000

COMPLETED

Harbin medical university cancer hospital, Harbin

200434

ACTIVE_NOT_RECRUITING

Shanghai Fourth People s Hospital, Shanghai

210008

ACTIVE_NOT_RECRUITING

Nanjing Drum Tower Hospital, Nanjing

214023

COMPLETED

Wuxi People s Hospital, Wuxi

300020

ACTIVE_NOT_RECRUITING

Institute of Hematology and Blood Diseases Hospital, Tianjin

300060

ACTIVE_NOT_RECRUITING

Tianjin Medical University Cancer Institute and Hospital, Tianjin

302017

ACTIVE_NOT_RECRUITING

Bhagwan Mahaveer Cancer Hospital & Research Centre, Jaipur

310003

ACTIVE_NOT_RECRUITING

First affiliated Hospital of Zhejiang University, Hangzhou

325000

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

330006

ACTIVE_NOT_RECRUITING

The First Affiliated Hospital of NanChang University, Nanchang

350001

COMPLETED

Fujian Meidical University Union Hospital, Fuzhou

400030

COMPLETED

Chongqing University Cancer Hospital, Chongqing

410013

COMPLETED

The Third Xiangya Hospital, Central South University, Changsha

411004

ACTIVE_NOT_RECRUITING

Deenanath Mangeshkar Hospital and Research Centre, Pune

430023

ACTIVE_NOT_RECRUITING

Wuhan Union Hospital, Wuhan

450008

COMPLETED

Henan Cancer Hospital, Zhengzhou

511363

ACTIVE_NOT_RECRUITING

Sun Yat -Sen University Cancer Center, Guangzhou

518025

ACTIVE_NOT_RECRUITING

Shenzhen 2nd People's Hospital, Shenzhen

530021

ACTIVE_NOT_RECRUITING

First Affiliated Hospital of Guangxi Medical University, Nanning

610032

ACTIVE_NOT_RECRUITING

Sichuan Provincial Peoples Hospital, Chengdu

710004

ACTIVE_NOT_RECRUITING

The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

3436212

ACTIVE_NOT_RECRUITING

Carmel Medical Center, Haifa

3810101

COMPLETED

Hillel Yaffe Medical Center, Hadera

4200072

ACTIVE_NOT_RECRUITING

Instituto Portugues de Oncologia, Porto

06030

ACTIVE_NOT_RECRUITING

University of Connecticut, Farmington

02118

ACTIVE_NOT_RECRUITING

Boston University Medical Center, Boston

08103

ACTIVE_NOT_RECRUITING

Cooper Health System MD Anderson Cancer Center at Cooper, Camden

A-1090

COMPLETED

Medical University Vienna MUV, Vienna

70390-140

COMPLETED

Hospitais Integradaos da Gavea S/A - DF Star, Brasília

95070 560

COMPLETED

Fundacao Universidade de Caxias do Sul, Caxias do Sul

81520 060

ACTIVE_NOT_RECRUITING

Liga Paranaense de Combate ao Cancer, Curitiba

89201-260

ACTIVE_NOT_RECRUITING

Instituto Joinvilense de Hematologia e Oncologia Ltda Centro de Hematologia e Oncologia, Joinville

59062 000

COMPLETED

Liga Norte Riograndense Contra O Cancer, Natal

24020-073

ACTIVE_NOT_RECRUITING

Complexo Hospitalar de Niteroi, Niterói

22775-001

COMPLETED

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI), Rio de Janeiro

41253-190

ACTIVE_NOT_RECRUITING

Hospital Sao Rafael, Salvador

15090-000

ACTIVE_NOT_RECRUITING

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base, São José do Rio Preto

01308-901

COMPLETED

Sociedade Beneficente de Senhoras Hospital Sirio Libanes, São Paulo

01321-001

ACTIVE_NOT_RECRUITING

Real e Benemérita Associação Portuguesa de Beneficência, São Paulo

01323-001

ACTIVE_NOT_RECRUITING

Hospital Alemao Oswaldo Cruz, São Paulo

01401 002

ACTIVE_NOT_RECRUITING

Instituto D Or de Pesquisa e Ensino IDOR, São Paulo

01509 900

ACTIVE_NOT_RECRUITING

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

04537 081

ACTIVE_NOT_RECRUITING

Clinica Medica Sao Germano LTDA, São Paulo

05652-900

COMPLETED

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

T2N 5G2

ACTIVE_NOT_RECRUITING

Arthur J E Child Comprehensive Cancer Centre, Calgary

E2L 4L2

COMPLETED

Saint John Regional Hospital, Saint John

L6R 3J7

COMPLETED

Brampton Civic Hospital, Brampton

L1G2B9

ACTIVE_NOT_RECRUITING

Lakeridge Health Oshawa, Oshawa

H1T 2M4

ACTIVE_NOT_RECRUITING

CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont, Montreal

625 00

ACTIVE_NOT_RECRUITING

Fakultni nemocnice Brno, Brno

779 00

COMPLETED

Fakultni nemocnice Olomouc, Olomouc

708 52

ACTIVE_NOT_RECRUITING

Fakultni Nemocnice Ostrava, Ostrava - Poruba

128 08

ACTIVE_NOT_RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

DK-2100

ACTIVE_NOT_RECRUITING

Rigshospitalet, Copenhagen

03048

COMPLETED

Medizinische Universitat Lausitz Carl Thiem, Cottbus

01307

ACTIVE_NOT_RECRUITING

Universitatsklinikum Carl Gustav Carus Dresden, Dresden

08060

ACTIVE_NOT_RECRUITING

Heinrich-Braun-Klinikum gGmbH, Zwickau

115 28

ACTIVE_NOT_RECRUITING

Alexandra General Hospital of Athens, Athens Attica

263 35

ACTIVE_NOT_RECRUITING

Agios Andreas General Hospital of Patra, Pátrai

570 10

ACTIVE_NOT_RECRUITING

G Papanikolaou Hospital of Thessaloniki, Thessaloniki

00128

ACTIVE_NOT_RECRUITING

Campus Bio Medico di Roma, Roma

113 8519

ACTIVE_NOT_RECRUITING

Institute of Science Tokyo Hospital, Bunkyō City

260-8717

ACTIVE_NOT_RECRUITING

Chiba Cancer Center, Chiba

503-8502

ACTIVE_NOT_RECRUITING

Ogaki Municipal Hospital, Gifu

377-0280

ACTIVE_NOT_RECRUITING

National Hospital Organization Shibukawa Medical Center, Gunma

573 1191

ACTIVE_NOT_RECRUITING

Kansai Medical University Hospital, Hirakata

317-0077

ACTIVE_NOT_RECRUITING

Hitachi General Hospital, Hitachi

350-0495

ACTIVE_NOT_RECRUITING

Saitama Medical University Hospital, Iruma-gun

296-8602

ACTIVE_NOT_RECRUITING

Kameda Medical Center, Kamogawa

277 8577

ACTIVE_NOT_RECRUITING

National Cancer Center Hospital East, Kashiwa

710-8602

ACTIVE_NOT_RECRUITING

Kurashiki Central Hospital, Kurashiki

790-8524

ACTIVE_NOT_RECRUITING

Matsuyama Red Cross Hospital, Matsuyama

480-1195

ACTIVE_NOT_RECRUITING

Aichi Medical University Hospital, Nagakute

852-8511

ACTIVE_NOT_RECRUITING

JRC Nagasaki Genbaku Hospital, Nagasaki

951 8520

ACTIVE_NOT_RECRUITING

Niigata University Medical And Dental Hospital, Niigata

701-1192

ACTIVE_NOT_RECRUITING

National Hospital Organization Okayama Medical Center, Okayama

545 8586

ACTIVE_NOT_RECRUITING

Osaka Metropolitan University Hospital, Osaka

060-8648

COMPLETED

Hokkaido University Hospital, Sapporo

113-0033

ACTIVE_NOT_RECRUITING

Juntendo University Hospital, Tokyo

135 8550

ACTIVE_NOT_RECRUITING

The Cancer Institute Hospital of JFCR, Tokyo

990 2331

ACTIVE_NOT_RECRUITING

Yamagata University Hospital, Yamagata

400-8506

ACTIVE_NOT_RECRUITING

Yamanashi Prefectural Central Hospital, Yamanashi

3813 TZ

ACTIVE_NOT_RECRUITING

Meander Medisch Centrum, Amersfoort

1081 HV

ACTIVE_NOT_RECRUITING

VUMC Amsterdam, Amsterdam

9700 RB

ACTIVE_NOT_RECRUITING

Universitair Medisch Centrum Groningen, Groningen

3584 CX

ACTIVE_NOT_RECRUITING

UMC Utrecht, Utrecht

80 214

ACTIVE_NOT_RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

40 519

ACTIVE_NOT_RECRUITING

Pratia Onkologia Katowice, Katowice

25 734

ACTIVE_NOT_RECRUITING

Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach, Kielce

20-081

ACTIVE_NOT_RECRUITING

Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie, Lublin

2805-267

COMPLETED

Uls Almada Seixal - Hosp. Garcia de Orta, Almada

4710-243

ACTIVE_NOT_RECRUITING

Uls Braga - Hosp. Braga, Braga

1400-038

TERMINATED

Champalimaud Foundation Champalimaud Centre, Lisbon

4434-502

ACTIVE_NOT_RECRUITING

Uls Gaia Espinho, Vila Nova de Gaia

08916

ACTIVE_NOT_RECRUITING

Hosp. Univ. Germans Trias I Pujol, Badalona

08908

COMPLETED

Institut Catala d Oncologia L Hospitalet, L'Hospitalet de Llobregat

07198

ACTIVE_NOT_RECRUITING

Hosp. Son Llatzer, Palma de Mallorca

791 82

ACTIVE_NOT_RECRUITING

Falu Lasarett Medicinkliniken Falun, Falun

751 85

ACTIVE_NOT_RECRUITING

Akademiska Sjukhuset, Uppsala

06010

ACTIVE_NOT_RECRUITING

Ankara Gulhane Training and Research Hospital, Ankara

06200

ACTIVE_NOT_RECRUITING

Dr Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara

06620

ACTIVE_NOT_RECRUITING

Ankara University Medical Faculty, Ankara

06680

ACTIVE_NOT_RECRUITING

Liv Hospital Ankara, Ankara

07100

COMPLETED

Antalya Training And Research Hospital, Antalya

AB25 2ZN

COMPLETED

Aberdeen Royal Infirmary, Aberdeen

B15 2GW

ACTIVE_NOT_RECRUITING

University Hospitals Birmingham NHS Foundation Trust, Birmingham

CO4 5JL

ACTIVE_NOT_RECRUITING

Colchester Hospital University NHS, Colchester

L7 8YA

ACTIVE_NOT_RECRUITING

The Clatterbridge Cancer Centre, Liverpool

SW10 9NH

COMPLETED

Chelsea And Westminster Hospital, London

SW17 0QT

ACTIVE_NOT_RECRUITING

St Georges Hospital, London

Ts4 3Bw

ACTIVE_NOT_RECRUITING

James Cook University Hospital, Middlesbrough

NR4 7UY

ACTIVE_NOT_RECRUITING

Norfolk and Norwich University Hospital, Norwich

ST4 6QG

ACTIVE_NOT_RECRUITING

Royal Stoke University Hospital, Staffordshire

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY