Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation

PHASE3RecruitingINTERVENTIONAL
Enrollment

840

Participants

Timeline

Start Date

January 2, 2023

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Scheduled Cardiac Surgery With Extracorporeal CirculationVasoplegic Syndrome
Interventions
DRUG

Vasopressin

The infusion is started at 5 ml hr-1, increased in increments of 1 ml hr-1 every 5 minutes to reach a maximum target rate of 30 ml hr-1

DRUG

Norepinephrine

The infusion is started at 5 ml h-1, increased in increments of 1 ml h-1 every 5 minutes to a maximum target rate of 30 ml h-1

OTHER

Collection of clinical data

At D1, D2, D7, D30 or D60 and D90

OTHER

Quality of Life Questionnaire EQ-5D

At the anesthesia consultation, discharge from intensive care, D7, D30 and D90

Trial Locations (1)

Unknown

RECRUITING

Chu Dijon Bourgogne, Dijon

All Listed Sponsors
lead

Centre Hospitalier Universitaire Dijon

OTHER