A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/Ritonavir

PHASE2CompletedINTERVENTIONAL
Enrollment

436

Participants

Timeline

Start Date

October 19, 2022

Primary Completion Date

September 27, 2023

Study Completion Date

February 9, 2024

Conditions
COVID-19
Interventions
DRUG

nirmatrelvir

Participants will receive 2 tablets of nirmatrelvir every 12 hours

DRUG

ritonavir

Participants will receive 1 capsule of ritonavir every 12 hours

DRUG

placebo for nirmatrelvir

Participants will receive 2 tablets of placebo for nirmatrelvir every 12 hours. A placebo does not have any medicine in it but looks just like the medicine being studied.

Trial Locations (84)

220

Far Eastern Memorial Hospital, New Taipei City

407

Taichung Veterans General Hospital, Taichung

10002

National Taiwan University Hospital, Taipei

10467

Montefiore Medical Center, The Bronx

11217

Taipei Veterans General Hospital, Taipei

11527

"Thoracic General Hospital of Athens I Sotiria", Athens

"General Hospital of Athens Laiko", Athens

15009

Heritage Valley Multispecialty Group, Inc, Beaver

20009

Emerson Clinical Research Institute - Washington - Connecticut Avenue, Washington D.C.

20011

Emerson Clinical Research Institute, Washington D.C.

20122

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan

20157

ASST Fatebenefratelli Sacco, Milan

21075

Centennial Medical Group, Elkridge

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

28208

Onsite Clinical Solutions (secondary location), Charlotte

OnSite Clinical Solutions, Charlotte

28401

Accellacare - Wilmington, Wilmington

32789

Clinical Site Partners, LLC dba CSP Orlando, Winter Park

Clinical Site Partners, LLC dba Flourish Research, Winter Park

32808

Omega Research Orlando, Orlando

33014

Pro-Care Research Center, Corp., Miami Gardens

33016

NeoClinical Research, Hialeah

Sweet Hope Research Specialty, Inc, Hialeah

33018

Unlimited Medical Research Group LLC, Hialeah Gardens

33064

NAPA Research, Pompano Beach

33126

LCC Medical Research Institute, Miami

Premium Medical Research Corp, Miami

33134

Herco Medical and Research Center Inc, Coral Gables

33135

Global Health Clinical Trials, Miami

South Florida Research Center, Miami

33165

Reliant Medical Research, Miami

33175

Innova Pharma Research, Miami

33176

Entrust Clinical Research, Miami

Reed Medical Research, Miami

33185

Kendall South Medical Center, Miami

33511

Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research, Brandon

33549

Asclepes Research Center - Spring Hill, Lutz

33609

Palm Harbor Dermatology PA d/b/a TrueBlue Clinical Research, Tampa

33615

Santos Research Center, Tampa

33705

GCP Research, Global Clinical professionals, St. Petersburg

33710

Theia Clinical Research - 5th Avenue North, St. Petersburg

34609

Asclepes Research Center - Spring Hill, Spring Hill

38261

Premier Primary Care, Union City

38654

Olive Branch Family Medical Center, Olive Branch

43214

WellNow Urgent Care and Research - Columbus, Columbus

48073

Beaumont Infectious Diseases Research, Royal Oak

48201

C.S. Mott Clinical Research Center (CRC), Detroit

48706

Great Lakes Research Group, Inc., Bay City

54636

AHEPA University General Hospital of Thessaloniki, Thessaloniki

59701

Mercury Street Medical Group, PLLC, Butte

60637

University of Chicago Medical Center, Chicago

75235

Southwest Family Medicine Associates, Dallas

77021

Next Innovative Clinical Research, Houston

77057

Next Level Urgent Care, Houston

77338

Accurate Clinical Research - East Humble, Humble

Accurate Clinical Research, Inc, Humble

78215

Sun Research Institute, San Antonio

78526

Headlands Research - Brownsville, Brownsville

79714

Nayak Research, LLC, Andrews

80033

Paradigm Clinical Research Centers, Inc, Wheat Ridge

83221

Bingham Memorial Hospital, Blackfoot

85031

Abby's Research institute, Phoenix

85210

The Institute for Liver Health dba Arizona Clinical Trials, Mesa

85378

Epic Medical Research - Surprise, Surprise

89109

Excel Clinical Research, LLC, Las Vegas

90129

A.O.U. Policlinico Paolo Giaccone, Palermo

90806

CVS Health - 8876 - Long Beach, Long Beach

91303

Hope Clinical Research, Inc., Canoga Park

91606

Carbon Health - North Hollywood - NoHo West, North Hollywood

91942

Paradigm Clinical Research Centers, Inc, La Mesa

92806

Smart Cures Clinical Research, Anaheim

92835

Ascada Health PC dba Ascada Research, Fullerton

Ascada Research, Fullerton

97404

Willamette Valley Clinical Studies, Eugene

98052

Eastside Research Associates, Redmond

01655

University of Massachusetts Chan Medical School, Worcester

08816

CVS Health - Site 02815 East Brunswick, East Brunswick

07753

Hackensack Meridian Jersey Shore University Medical Center, Neptune City

N1H 1B1

Dawson Clinical Research, Guelph

L8M 1K7

Hamilton Medical Research Group, Hamilton

L1G 4T3

Medical Trust Clinics, Oshawa

K0C 2K0

Winchester District Memorial Hospital, Winchester

106 76

Evangelismos General Hospital of Athens, Athens

115 28

Alexandra General Hospital of Athens, Athens

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY