Precision Medicine for Stem Cell Transplantation

RecruitingOBSERVATIONAL
Enrollment

300

Participants

Timeline

Start Date

June 6, 2023

Primary Completion Date

August 31, 2025

Study Completion Date

August 31, 2028

Conditions
Haematopoietic Stem Cell Transplantation
Interventions
PROCEDURE

Blood sample collection

"Enrolled patients will undergo sequential blood collection beginning prior to conditioning, then on the day of transplant (day 0), followed by days 7, 14, 21, 28, 56 (2 months) and 90 (3 months) post-transplant.~Bone marrow aspirates taken within this period as part of routine care will also be collected, these are typically performed around day 100 and whenever there is suspicion of disease recurrence.~The study will also collect an additional blood sample at the onset of treatment for aGvHD for those who receive systemic corticosteroids (PO or IV steroid equivalent to ≥0.5mg/kg prednisolone)."

PROCEDURE

Bone marrow aspirate

Bone marrow aspirates taken within this period as part of routine care will also be collected, these are typically performed around day 100 and whenever there is suspicion of disease recurrence.

Trial Locations (3)

m13 9wl

RECRUITING

Manchester Royal Infirmary, Manchester

m139wl

RECRUITING

Royal Manchester Children's Hospital, Manchester

M20 4BX

RECRUITING

The Christie NHS Foundation Trust, Manchester

All Listed Sponsors
collaborator

The Christie NHS Foundation Trust

OTHER

lead

University of Manchester

OTHER