Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation

NARecruitingINTERVENTIONAL
Enrollment

3,500

Participants

Timeline

Start Date

August 17, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Cardiac Arrest With Successful ResuscitationHypoxia, Brain
Interventions
DEVICE

Feedback-controlled temperature device

If core body temperature exceeds 37.7°C a feedback controlled-device will be used and set at 37.5°C.

OTHER

High MAP

A MAP target of \>85mmHg will be used. Vasopressors will be titrated to this target during 36h.

OTHER

Deep sedation

Deep sedation for at least 36h

OTHER

Fever control without a device

Management of fever in the ICU without a device

OTHER

Low MAP

A MAP target of \>65mmHg will be used. Vasopressors will be titrated to this target during 36h.

OTHER

Minimal sedation

A strategy of minimal sedation in the ICU, used only as needed to facilitate transport, imaging and invasive procedures.

Trial Locations (56)

1077

RECRUITING

HUB Hôpital Erasme, Brussels

3620

RECRUITING

Ziekenhuis Oost-Limburg Hospital, Lanaken

9000

RECRUITING

Ghent University Hospital, Ghent

13409

RECRUITING

North Estonia Medical Centre, Tallinn, Tallinn

Unknown

RECRUITING

Nepean Hospital, Kingswood

RECRUITING

Liverpool Hospital, Liverpool

RECRUITING

Royal North Shore Hospital, Sydney

RECRUITING

St George Hospital, Sydney

RECRUITING

The Sutherland Hospital, Sydney

RECRUITING

Princess Alexandra Hospital, Brisbane

RECRUITING

The Prince Charles Hospital, Brisbane

RECRUITING

Austin Hospital, Melbourne

RECRUITING

Jorvi Hospital, Espoo

RECRUITING

Helsinki Helsingforgs University Central Hospital, Helsinki

RECRUITING

Jyväskylä Hospital, Jyväskylä

RECRUITING

Kuopio University Hospital, Kuopio

RECRUITING

Oulu University Hospital, Oulu

RECRUITING

Tampere University Hospital, Tampere

RECRUITING

Charite University Hospital, Berlin

RECRUITING

Lübeck University Hospital, Lübeck

RECRUITING

Tubingen University Hospital, Tübingen

ACTIVE_NOT_RECRUITING

St Vincents University Hospital, Dublin

RECRUITING

San Martino Hospital Genova, Genova

RECRUITING

Centre Hospitalier de Luxembourg, Luxembourg

RECRUITING

DCCM ICU, Auckland

RECRUITING

Middlemore ICU, Auckland

RECRUITING

North Shore ICU NZ, Auckland

RECRUITING

Christchurch Hospital, Christchurch

ACTIVE_NOT_RECRUITING

Whangarei ICU, Northland

RECRUITING

Wellington Hospital, Wellington

RECRUITING

Soerlandet Hospital Arendal, Arendal

RECRUITING

Kalnes Hospital, Kalnes

RECRUITING

Oslo University Hospital, Oslo

RECRUITING

Stavanger University Hospital, Stavanger

RECRUITING

King Abdulaziz Medical City, Riyadh

RECRUITING

Tan Tock Seng Hospital, Singapore

RECRUITING

Hallands hospital, Halmstad

RECRUITING

Helsingborg Hospital, Helsingborg

RECRUITING

Skåne University Hospital, Lund

RECRUITING

Skåne University Hospital Malmö, Malmo

RECRUITING

Sahlgrenska University Hospital, Gothenburg

RECRUITING

Karlstad hospital, Karlstad

RECRUITING

Skaraborg Hospital Skovde, Skövde

RECRUITING

Karolinska University Hospital, Stockholm

RECRUITING

University Hospital of Umeå, Umeå

RECRUITING

Bern University Hospital, Bern

RECRUITING

St Gallen Hospital, Sankt Gallen

RECRUITING

University Hospital Zürich, Zurich

RECRUITING

Essex Cardiothoracic Centre, Basildon

RECRUITING

Bristol Royal Infirmary, Bristol

RECRUITING

Cardiff University Hospital, Cardiff

RECRUITING

Leeds General Infirmary, Leeds

RECRUITING

Kings College Hospital, London

RECRUITING

St Bartholomew's Hospital, London

RECRUITING

St Georges University Hospital, London

00290

RECRUITING

Meilahti Hospital, Helsinki

All Listed Sponsors
collaborator

Lund University, Lund, Sweden

UNKNOWN

collaborator

Copenhagen Trial Unit, Center for Clinical Intervention Research

OTHER

collaborator

The George Institute for Global Health, Australia

OTHER

collaborator

HUS Helsinki University Hospitals, Helsinki, Finland

UNKNOWN

collaborator

Medical Research Institute of New Zealand Rangahautia Te Ora, Wellington, New Zealand

UNKNOWN

collaborator

University Hospital of Wales

OTHER

lead

Region Skane

OTHER

NCT05564754 - Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation | Biotech Hunter | Biotech Hunter